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Found 1481 with Last Name = 'matter' and Initial = 'h'
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12396(1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3...)
Affinity DataKi:  0.0700nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12389(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.100nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12387(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.25nM ΔG°:  -54.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12395(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.300nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590085(CHEMBL5187102)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12384(2-Carboxyindole Scaffold 35 | 7-Chloro-1-[5-(5-chl...)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM15867(1-{[(5-chloropyridin-2-yl)carbamoyl]methyl}-N-[1-(...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12388(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12381(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12379(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12390(1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12391(2-Carboxyindole Scaffold 23 | 3-chloro-1-{[5-(5-ch...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12392(2-Carboxyindole Scaffold 24 | 3-Bromo-1-[5-(5-chlo...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50065451(2-Amino-N-{4-[(2S,5S,8S,14S,17R)-8,14-dibenzyl-5-(...)
Affinity DataKi:  2.30nMAssay Description:In vitro inhibition of radioligand binding to human somatostatin receptor (hsst2) expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12372(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12372(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM15862(1-{[3-(5-chlorothiophen-2-yl)-1,2-oxazol-5-yl]meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12400(1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12372(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12372(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  3nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12385(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12393(1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3...)
Affinity DataKi:  3nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12400(1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-...)
Affinity DataKi:  3nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12400(1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-...)
Affinity DataKi:  3nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590072(CHEMBL3904655)
Affinity DataKi:  3nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12374(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590086(CHEMBL5192536)
Affinity DataKi:  4nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM15863(1-{[5-(5-chlorothiophen-2-yl)-1,3,4-thiadiazol-2-y...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12375(2-Carboxyindole Scaffold 26 | 5-Chloro-1-[5-(5-chl...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50096459(1-(3-Carbamimidoyl-benzyl)-4-hydroxy-1H-indole-2-c...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against serine protease factor Xa (fXa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-3(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50138684((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  5nMAssay Description:Binding affinity to MMP11More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50065453((5S,8S,11S,14R,17S,19aS)-11-(4-Amino-butyl)-5,17-d...)
Affinity DataKi:  5.10nMAssay Description:In vitro inhibition of radioligand binding to human somatostatin receptor (hsst2) expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590082(CHEMBL5175184)
Affinity DataKi:  6nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13863(3-amidinobenzylindole carboxamide 47 | N,1-bis[(3-...)
Affinity DataKi:  7nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12382(2-Carboxyindole Scaffold 33 | 4-Chloro-1-[5-(5-chl...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50065450(2-Amino-3-phenyl-N-{4-[(2S,5S,8S,14S,17R)-8,10,14-...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of radioligand binding to human somatostatin receptor (hsst2) expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12397(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  7nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590073(CHEMBL5175600)
Affinity DataKi:  7nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12383(2-Carboxyindole Scaffold 34 | 6-Chloro-1-[5-(5-chl...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590087(CHEMBL5179837)
Affinity DataKi:  8nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13825(3-amidinobenzylindole carboxamide 9 | N,1-bis[(3-c...)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13861(1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dimethyl...)
Affinity DataKi:  9nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13866(3-amidinobenzylindole carboxamide 50 | CHEMBL30744...)
Affinity DataKi:  9nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13866(3-amidinobenzylindole carboxamide 50 | CHEMBL30744...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against serine protease factor Xa (fXa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12378(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590097(CHEMBL5187449)
Affinity DataKi:  9nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12376(2-Carboxyindole Scaffold 27 | 5-Bromo-1-[5-(5-chlo...)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13662(3-Oxybenzamide 48 | 4-chloro-3-[2-(2,4-dichlorophe...)
Affinity DataKi:  10nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM13662(3-Oxybenzamide 48 | 4-chloro-3-[2-(2,4-dichlorophe...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50138684((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  10nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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