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Found 370 with Last Name = 'mcallister' and Initial = 'l'
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432208(CHEMBL2347110)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426340(CHEMBL2321943)
Affinity DataKi:  1.70nMAssay Description:Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107730(CHEMBL2347108 | US8933095, 14)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426341(CHEMBL2321944)
Affinity DataKi:  7.10nMAssay Description:Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50386310(CHEMBL2049092)
Affinity DataKi:  7.70nMAssay Description:Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107747(CHEMBL2347115 | US8933095, 4)
Affinity DataKi:  12nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50386292(CHEMBL2047851)
Affinity DataKi:  14nMAssay Description:Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50386292(CHEMBL2047851)
Affinity DataKi:  14nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107738(CHEMBL2347113 | US8933095, 22)
Affinity DataKi:  22nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107746(CHEMBL2347107 | US8933095, 1)
Affinity DataKi:  23nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107720(CHEMBL2347112 | US8598200, 2)
Affinity DataKi:  32nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432200(CHEMBL2347109 | US8933095, 16)
Affinity DataKi:  41nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM107722(CHEMBL2347114 | US8933095, 5)
Affinity DataKi:  48nMAssay Description:Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250852(CHEMBL4078217)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250848(CHEMBL4059676)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250859(CHEMBL4097203)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474403(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(phenylsulfony...)
Affinity DataIC50:  0.259nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250855(CHEMBL4077745)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250850(CHEMBL4089505)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250852(CHEMBL4078217)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474408(1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-[methyl(p...)
Affinity DataIC50:  0.470nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250855(CHEMBL4077745)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395921(CHEMBL2164511)
Affinity DataIC50:  0.511nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485077(CHEMBL2023517)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485061(CHEMBL2023524)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474444(US10858373, Example 42)
Affinity DataIC50:  0.587nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395911(CHEMBL2164521)
Affinity DataIC50:  0.657nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474454(US10858373, Example 52)
Affinity DataIC50:  0.666nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250859(CHEMBL4097203)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474429(US10858373, Example 27)
Affinity DataIC50:  0.679nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250854(CHEMBL4079190)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395920(CHEMBL2164512)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395910(CHEMBL2164522)
Affinity DataIC50:  0.912nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474416(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-{[6-(difluorom...)
Affinity DataIC50:  0.942nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485056(CHEMBL2023515)
Affinity DataIC50:  1nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474404(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-[(4-fluorophen...)
Affinity DataIC50:  1nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255776(CHEMBL4075310)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474434(US10858373, Example 32)
Affinity DataIC50:  1.08nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485060(CHEMBL2023522)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485076(CHEMBL2023402)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250854(CHEMBL4079190)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485083(CHEMBL2023523)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485078(CHEMBL2023521)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485059(CHEMBL2023520)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485084(CHEMBL2023518)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395909(CHEMBL2164523)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474435(US10858373, Example 33)
Affinity DataIC50:  1.21nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM474443(US10858373, Example 41)
Affinity DataIC50:  1.25nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485058(CHEMBL2023519)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC expressed in Escherichia coli using UDP-3-O-N-acetylglucosamine substrate measured after 30 mins by mass sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395908(CHEMBL2164524)
Affinity DataIC50:  1.39nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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