TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Zobio
Curated by ChEMBL
Zobio
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Zobio
Curated by ChEMBL
Zobio
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Selectivity towards cytochrome P450 3A4 enzyme activityMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Selectivity towards cytochrome P450 3A4 enzyme activityMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Zobio
Curated by ChEMBL
Zobio
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell
Curated by ChEMBL
Hibercell
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair