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Found 1316 with Last Name = 'mulvihill' and Initial = 'mj'
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437357(CHEMBL3037909)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437358(CHEMBL3037908)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183224(3-[6-(2-dimethylamino-1-imidazol-1-yl-butyl)-napht...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183243(1-((6-((1R,2R)-2-(diethylamino)-1-(1H-imidazol-1-y...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183229(1-((6-((1R,2R)-1-(1H-imidazol-1-yl)-2-(isopropyl(m...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336325(CHEMBL1667943 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570964(CHEMBL4857782)
Affinity DataIC50:  2nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557619(CHEMBL4796239)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570956(CHEMBL4869882)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437358(CHEMBL3037908)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183237(3-(6-((1R,2R)-1-(1H-imidazol-1-yl)-2-(isopropyl(me...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570959(CHEMBL4870780)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570958(CHEMBL4853221)
Affinity DataIC50:  3nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162787(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162787(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162776(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162776(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570941(CHEMBL4862478)
Affinity DataIC50:  4nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50438224(CHEMBL2407759)
Affinity DataIC50:  4nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162783(CHEMBL179825 | {4-[6-(2-Dimethylamino-1-imidazol-1...)
Affinity DataIC50:  4nMAssay Description:Selectivity towards cytochrome P450 3A4 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570955(CHEMBL4863698)
Affinity DataIC50:  4nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162780(CHEMBL180348 | {4-[6-(2-Dimethylamino-1-imidazol-1...)
Affinity DataIC50:  4nMAssay Description:Selectivity towards cytochrome P450 3A4 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437357(CHEMBL3037909)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437370(CHEMBL3037912)
Affinity DataIC50:  4nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336329(CHEMBL1667947 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183231(1-((6-((1R,2R)-2-(ethyl(methyl)amino)-1-(1H-imidaz...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336327(CHEMBL1667945 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336324(CHEMBL1667942 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336323(CHEMBL1667941 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336321(CHEMBL1667939 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557620(CHEMBL4752978)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437369(CHEMBL3037913)
Affinity DataIC50:  5nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570966(CHEMBL4861671)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183225(3-(6-((1R,2R)-2-(diethylamino)-1-(1H-imidazol-1-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336315(CHEMBL1667948 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570960(CHEMBL4858308)
Affinity DataIC50:  6nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336322(CHEMBL1667940 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162791(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162791(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162788(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162788(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50:  7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437358(CHEMBL3037908)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183228(1-((6-((1R,2R)-2-(dimethylamino)-1-(1H-imidazol-1-...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336318(CHEMBL1667936 | trans-2-(3-(-4-ethylcyclohexyl)-7-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437367(CHEMBL3037915)
Affinity DataIC50:  8nMAssay Description:Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162782(CHEMBL179550 | {4-[6-(2-Dimethylamino-1-imidazol-1...)
Affinity DataIC50:  8nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570972(CHEMBL4848359)
Affinity DataIC50:  8nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339062(4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...)
Affinity DataIC50:  8nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336328(CHEMBL1667946 | trans-4-(8-amino-1-(8-fluoro-2-phe...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Hibercell

Curated by ChEMBL
LigandPNGBDBM50570963(CHEMBL4848143)
Affinity DataIC50:  9nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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