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Found 244 with Last Name = 'nilsson' and Initial = 'p'
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50:  0.248nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50:  0.248nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50:  0.289nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50:  0.289nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM310035((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)
Affinity DataIC50:  0.483nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223289((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)
Affinity DataIC50:  0.483nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50:  0.658nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50:  0.658nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109729(CHEMBL3604185)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109751(CHEMBL3604184)
Affinity DataIC50:  4nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50:  9nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50:  9nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50:  10nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109746(CHEMBL3604180)
Affinity DataIC50:  13nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109814(CHEMBL3604153)
Affinity DataIC50:  14nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50105870(CHEMBL3597768)
Affinity DataIC50:  17nMAssay Description:Inhibition of human 15-LOX-1 using arachidonic acid as substrate by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223281(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4...)
Affinity DataIC50:  17nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223281(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4...)
Affinity DataIC50:  17nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223226(2-(5-((4-Chloronaphthalen-1-yl)(cyclopropylmethyl)...)
Affinity DataIC50:  18nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223232(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  18nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223284(2-(5-((Cyclopropylmethyl)(4-methylnaphthalen-1-yl)...)
Affinity DataIC50:  18nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223226(2-(5-((4-Chloronaphthalen-1-yl)(cyclopropylmethyl)...)
Affinity DataIC50:  18nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223232(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  18nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223284(2-(5-((Cyclopropylmethyl)(4-methylnaphthalen-1-yl)...)
Affinity DataIC50:  18nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223283(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  19nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM310005(2-(5-((Cyclopropylmethyl)(4-(trifluoromethyl)napht...)
Affinity DataIC50:  19nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223283(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  19nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223259(2-(5-((Cyclopropylmethyl)(4-(trifluoromethyl)napht...)
Affinity DataIC50:  19nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109746(CHEMBL3604180)
Affinity DataIC50:  20nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109813(CHEMBL3604152)
Affinity DataIC50:  22nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223239(2-(5-((Cyclopropylmethyl)(4-methylbenzyl)amino)-3-...)
Affinity DataIC50:  22nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223239(2-(5-((Cyclopropylmethyl)(4-methylbenzyl)amino)-3-...)
Affinity DataIC50:  22nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109568(CHEMBL3604132)
Affinity DataIC50:  24nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223234(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-3...)
Affinity DataIC50:  24nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223234(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-3...)
Affinity DataIC50:  24nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223262(2-(5-((Cyclopropylmethyl)(5-(trifluoromethyl)napht...)
Affinity DataIC50:  25nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223262(2-(5-((Cyclopropylmethyl)(5-(trifluoromethyl)napht...)
Affinity DataIC50:  25nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223271(2-(4-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  26nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223271(2-(4-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Affinity DataIC50:  26nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109539(CHEMBL3604138)
Affinity DataIC50:  26nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109643(CHEMBL3604158)
Affinity DataIC50:  27nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223237(2-(5-((Cyclopropylmethyl)(naphthalen-2-yl)amino)-3...)
Affinity DataIC50:  28nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223237(2-(5-((Cyclopropylmethyl)(naphthalen-2-yl)amino)-3...)
Affinity DataIC50:  28nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223263(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50:  31nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223263(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)
Affinity DataIC50:  31nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109814(CHEMBL3604153)
Affinity DataIC50:  32nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109730(CHEMBL3604151)
Affinity DataIC50:  33nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223227(2-(5-((4-Chlorobenzyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50:  34nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109729(CHEMBL3604185)
Affinity DataIC50:  34nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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