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Found 96 with Last Name = 'pérez' and Initial = 'a'
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez

Curated by ChEMBL
LigandPNGBDBM50275947((5S,14R,19S,28R)-10,23-dimethoxy-4,4,29,29-tetrame...)
Affinity DataKi:  420nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez

Curated by ChEMBL
LigandPNGBDBM50275948((4R,13S,19R,28R)-8,23-dimethoxy-14,14,29,29-tetram...)
Affinity DataKi:  510nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez

Curated by ChEMBL
LigandPNGBDBM50275945((1R,2R,4R,7bR,9R,11aR)-2,5,5,9,12,12-Hexamethyl-1,...)
Affinity DataKi:  770nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez

Curated by ChEMBL
LigandPNGBDBM50275949((4R,13S,19R,28R)-7,9,22,24-tetrabromo-14,14,29,29-...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez

Curated by ChEMBL
LigandPNGBDBM50275946((5R,14S,19S,28R)-10,23-dimethoxy-4,4,29,29-tetrame...)
Affinity DataKi:  1.04E+3nMAssay Description:Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Sus scrofa)
Instituto De QuíMica OrgáNica General (Csic)

Curated by ChEMBL
LigandPNGBDBM50004044(3-Hydroxy-4-methoxy-5-nitro-benzaldehyde | CHEMBL8...)
Affinity DataKi:  1.35E+4nMAssay Description:Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with variable AdoMet and saturating catechol as substrate (mixed inh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Sus scrofa)
Instituto De QuíMica OrgáNica General (Csic)

Curated by ChEMBL
LigandPNGBDBM50004044(3-Hydroxy-4-methoxy-5-nitro-benzaldehyde | CHEMBL8...)
Affinity DataKi:  1.72E+4nMAssay Description:Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with saturating AdoMet and variable catechol as substrate (noncompet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50310892(CHEMBL1078511 | N,N'-(9-(2-(1-methylpyrrolidin-2-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134027(CHEMBL140180 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134010(CHEMBL139511 | N,N'-(9-(2-aminophenylamino)acridin...)
Affinity DataIC50:  20nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134022(CHEMBL336444 | N,N'-(9-(4-acetylphenylamino)acridi...)
Affinity DataIC50:  40nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134002(CHEMBL141540 | N,N'-(9-(2-(piperidin-1-yl)ethylami...)
Affinity DataIC50:  50nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134032(CHEMBL138811 | N,N'-(9-(cyclopropylamino)acridine-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134019(CHEMBL336417 | N,N'-(9-(3-aminophenylamino)acridin...)
Affinity DataIC50:  60nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134009(CHEMBL335132 | N,N'-(9-(3-(dimethylamino)propylami...)
Affinity DataIC50:  60nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134025(CHEMBL343795 | N,N'-(9-(4-fluorophenylamino)acridi...)
Affinity DataIC50:  70nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134018(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)
Affinity DataIC50:  74nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50150618(CHEMBL182871 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134023(CHEMBL337762 | N,N'-(9-(4-aminophenylamino)acridin...)
Affinity DataIC50:  80nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134008(CHEMBL138187 | N,N'-(9-(3-(dimethylamino)propylami...)
Affinity DataIC50:  80nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134000(CHEMBL139287 | N,N'-(9-(cyclohexylamino)acridine-3...)
Affinity DataIC50:  90nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50150622(CHEMBL184587 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Affinity DataIC50:  98nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134026(CHEMBL138487 | N,N'-(9-(3-(dimethylamino)phenylami...)
Affinity DataIC50:  100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134020(CHEMBL141661 | N,N'-(9-(3-acetamidophenylamino)acr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134021(CHEMBL138761 | N,N'-(9-(3-(methylthio)phenylamino)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134011(CHEMBL343609 | N,N'-(9-(2-aminophenylamino)acridin...)
Affinity DataIC50:  110nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134006(CHEMBL335564 | N,N'-(9-(2-methoxyethylamino)acridi...)
Affinity DataIC50:  140nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50133998(CHEMBL137809 | N,N'-(9-(2-(methylthio)phenylamino)...)
Affinity DataIC50:  150nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50133999(CHEMBL345035 | N,N'-(9-(2-aminophenylamino)acridin...)
Affinity DataIC50:  170nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134017(CHEMBL138357 | N,N'-(9-(4-(dimethylamino)phenylami...)
Affinity DataIC50:  170nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50310879(CHEMBL1077669 | N,N'-(9-oxo-9,9a-dihydroacridine-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50155661(3-(4-Methyl-piperidin-1-yl)-N-{6-[3-(4-methyl-pipe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134028(CHEMBL142036 | N,N'-(9-(4-aminophenylamino)acridin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50155646(3-(4-Hydroxy-piperidin-1-yl)-N-{6-[3-(4-hydroxy-pi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134012(CHEMBL342480 | N,N'-(9-(3-aminophenylamino)acridin...)
Affinity DataIC50:  210nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134031(CHEMBL137973 | N,N'-(9-(cyclohexylamino)acridine-2...)
Affinity DataIC50:  210nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50310884(CHEMBL1078502 | N,N'-(9-(cycloheptylamino)acridine...)
Affinity DataIC50:  210nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50310886(1-(6-(4-(3,6-bis(3-(pyrrolidin-1-yl)propanamido)ac...)
Affinity DataIC50:  267nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134001(CHEMBL140084 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Affinity DataIC50:  270nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50150621(6-Oxo-6-pyrrolidin-1-yl-hexanoic acid {4-[3,6-bis-...)
Affinity DataIC50:  318nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50155667(CHEMBL1077951 | CHEMBL186019 | N-[9-Oxo-6-(3-piper...)
Affinity DataIC50:  400nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134003(CHEMBL141740 | N,N'-(9-(4-methoxyphenylamino)acrid...)
Affinity DataIC50:  460nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134013(CHEMBL341985 | N,N'-(9-(4-(dimethylamino)phenylami...)
Affinity DataIC50:  500nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134005(CHEMBL137928 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Affinity DataIC50:  570nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134033(CHEMBL139443 | N,N'-(9-(3-(dimethylamino)phenylami...)
Affinity DataIC50:  600nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50155645(3-Dimethylamino-N-[7-(3-dimethylamino-propionylami...)
Affinity DataIC50:  600nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50155655(3-Diethylamino-N-[6-(3-diethylamino-propionylamino...)
Affinity DataIC50:  700nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134014(CHEMBL343041 | N,N'-(9-(2-hydroxyphenylamino)acrid...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Central University Of Las Villas

Curated by ChEMBL
LigandPNGBDBM50134024(CHEMBL139500 | N,N'-(9-(3-aminophenylamino)acridin...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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