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Found 383 with Last Name = 'qiao' and Initial = 'h'
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50108659(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50108653(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50120472(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50108669(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDCN1-like protein 5(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN5 (unknown origin) (47 to 237 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  2.42nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386906(CHEMBL2048520)
Affinity DataKi:  2.64nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386905(CHEMBL2048519)
Affinity DataKi:  3.79nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50033116((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintil...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386907(CHEMBL2048521)
Affinity DataKi:  4.63nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386903(CHEMBL559741)
Affinity DataKi:  12nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  14nMAssay Description:Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386910(CHEMBL2048524)
Affinity DataKi:  18.3nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  21nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386911(CHEMBL2048525)
Affinity DataKi:  26.9nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi:  43nMAssay Description:Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in DCN1/UBC12 int...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 2(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  66nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN2 (unknown origin) (62 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386909(CHEMBL2048523)
Affinity DataKi:  135nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  168nMAssay Description:Displacement of ketanserin from human 5-HT2A receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay base...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  241nMAssay Description:Displacement of PNU-86170 from human dopamine D2 receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDCN1-like protein 2(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi:  313nMAssay Description:Inhibition of recombinant human GST-tagged DCN2 (62 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 3(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  592nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN3 (unknown origin) (86 to 304 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50386908(CHEMBL2048522)
Affinity DataKi:  699nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 4(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  807nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN4 (unknown origin) (102 to 292 residues) expressed in Escherichia coli BL21(DE3) assessed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 3(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN3 (86 to 304 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 4(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN4 (102 to 292 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 5(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50569336(CHEMBL4865016)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN5 (47 to 237 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of 8-OH-DPAT from human 5-HT1A receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay basedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50120472(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Affinity DataKi:  1.59E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat liver membranes measured after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of spiperone from human dopamine D4 receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Affinity DataKi:  5.78E+3nMAssay Description:Displacement of [3H]serotonin from recombinant human 5-HT1B receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50591658(CHEMBL5187881)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of N-terminal GST-fused human wild type EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.800nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50160871(BI 1482694 | HM61713 | Olmutinib)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM50299218(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Affinity DataIC50:  1nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.30nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  1.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  2nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM209859(4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpip...)
Affinity DataIC50:  4nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM50311316(CHEMBL1077739 | LDN-211904 | N-(2-chlorophenyl)-6-...)
Affinity DataIC50:  4.10nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM209858(Danusertib | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-...)
Affinity DataIC50:  4.40nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM209861(5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methyl...)
Affinity DataIC50:  4.80nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  7.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Wuhan Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50498654(CHEMBL3618319)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Wuhan Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50103642(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

LigandPNGBDBM50100615(E-7050 | E7050 | Golvatinib)
Affinity DataIC50:  13nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
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