Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]serotonin from recombinant human 5-HT1D receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding ...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes measured after 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN5 (unknown origin) (47 to 237 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 2.42nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 2.64nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 3.79nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintil...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 4.63nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 18.3nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...More data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 26.9nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in DCN1/UBC12 int...More data for this Ligand-Target Pair
Affinity DataKi: 66nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN2 (unknown origin) (62 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 135nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 168nMAssay Description:Displacement of ketanserin from human 5-HT2A receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay base...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 241nMAssay Description:Displacement of PNU-86170 from human dopamine D2 receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay ...More data for this Ligand-Target Pair
Affinity DataKi: 313nMAssay Description:Inhibition of recombinant human GST-tagged DCN2 (62 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Affinity DataKi: 592nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN3 (unknown origin) (86 to 304 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 699nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 807nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN4 (unknown origin) (102 to 292 residues) expressed in Escherichia coli BL21(DE3) assessed as...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN3 (86 to 304 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN4 (102 to 292 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged DCN5 (47 to 237 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 1.09E+3nMAssay Description:Displacement of 8-OH-DPAT from human 5-HT1A receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay basedMore data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 1.59E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat liver membranes measured after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Displacement of spiperone from human dopamine D4 receptor expressed in CHO cell membrane incubated for 1 hr by competitive radioligand binding assay ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 5.78E+3nMAssay Description:Displacement of [3H]serotonin from recombinant human 5-HT1B receptor expressed in HEK293 cells incubated for 1 hr by competitive radioligand binding ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Shaanxi University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of N-terminal GST-fused human wild type EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Wuhan Institute Of Technology
Curated by ChEMBL
Wuhan Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analy...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Wuhan Institute Of Technology
Curated by ChEMBL
Wuhan Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analy...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair