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Found 36 with Last Name = 'soldovieri' and Initial = 'mv'
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465610(CHEMBL4295040)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465611(CHEMBL4284808)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465610(CHEMBL4295040)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50159505(CHEMBL1779158 | N,N-Dibenzyltryptamine)
Affinity DataIC50:  367nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol mediated current amplitude at +80 mV holding potential b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataIC50:  475nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol mediated current amplitude at +80 mV holding potential b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataIC50:  475nMAssay Description:Antagonist activity at TRPM8 (unknown origin) assessed as reduction in menthol-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465611(CHEMBL4284808)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465615(CHEMBL4282067)
Affinity DataIC50:  865nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465618(CHEMBL4291622)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465619(CHEMBL4287812)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465614(CHEMBL4292679)
Affinity DataIC50:  2.20E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465613(CHEMBL4277563)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50159505(CHEMBL1779158 | N,N-Dibenzyltryptamine)
Affinity DataIC50:  3.20E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465620(CHEMBL4288211)
Affinity DataIC50:  3.30E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465609(CHEMBL4277150)
Affinity DataIC50:  3.30E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50331290(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Affinity DataIC50:  6.50E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465612(CHEMBL4279001)
Affinity DataIC50:  8.20E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465616(CHEMBL4284391)
Affinity DataIC50:  1.18E+4nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50465617(CHEMBL4280979)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Affinity DataEC50:  930nMAssay Description:Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526877(CHEMBL4545892)
Affinity DataEC50:  210nMAssay Description:Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526876(CHEMBL4457044)
Affinity DataEC50:  340nMAssay Description:Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526877(CHEMBL4545892)
Affinity DataEC50:  80nMAssay Description:Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526876(CHEMBL4457044)
Affinity DataEC50:  630nMAssay Description:Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Affinity DataEC50:  3.90E+3nMAssay Description:Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily KQT member 4(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526877(CHEMBL4545892)
Affinity DataEC50:  100nMAssay Description:Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 4(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526876(CHEMBL4457044)
Affinity DataEC50:  80nMAssay Description:Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 5(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526877(CHEMBL4545892)
Affinity DataEC50:  1.07E+3nMAssay Description:Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 5(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Affinity DataEC50:  800nMAssay Description:Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Affinity DataEC50:  1.72E+3nMAssay Description:Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526876(CHEMBL4457044)
Affinity DataEC50:  920nMAssay Description:Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 4(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)
Affinity DataEC50:  1.98E+3nMAssay Description:Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 5(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526876(CHEMBL4457044)
Affinity DataEC50:  350nMAssay Description:Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  7.50E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50159506(CHEMBL3787319)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 3(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50526877(CHEMBL4545892)
Affinity DataEC50:  1.05E+4nMAssay Description:Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed