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Found 3737 with Last Name = 'sprengeler' and Initial = 'pa'
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.0780nMAssay Description:Binding affinity for factor VIIa/TFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity of the compound towards urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50180517(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-ca...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101882(CHEMBL53829 | Phosphoric acid mono-{2-[3-(3-benzyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101871(3-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound towards Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101881(4-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181921(2-[5-(5-carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to factor7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50180400(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to f7aMore data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Celera

LigandPNGBDBM14338(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-nit...)
Affinity DataKi:  1.30nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189939(5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydrox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187167(CHEMBL211357 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187166(CHEMBL380293 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187177(CHEMBL212774 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187160(CHEMBL213928 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187163((S)-benzyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)b...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187168(CHEMBL377656 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187176((S)-ethyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)be...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187162((S)-N-(3-chlorophenethyl)-4-((3-(6-amino-2-pivalam...)
Affinity DataKi:  2nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181916(CHEMBL206168 | [5-(5-carbamimidoyl-1H-benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Binding affinity to factor7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50180400(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to F7a/TF complexMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101883(2-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101885(2-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187182((S)-N-(1-(5-(4-((3-chlorophenethyl)carbamoyl)benzy...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14352(2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)
Affinity DataKi:  2.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187164((S)-benzyl 1-(5-(4-((2-(thiophen-2-yl)ethyl)carbam...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50189938(2-{5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-3'-[3...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14351(2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-...)
Affinity DataKi:  2.60nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14312(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187169((S)-benzyl 1-(5-(4-((2-(4-fluorophenoxy)ethyl)carb...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103655(CHEMBL72231 | Phosphoric acid mono-{2-[5-(5-carbam...)
Affinity DataKi:  3nMAssay Description:Binding affinity for factor VIIa/TFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM14921(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Affinity DataKi:  3nMAssay Description:Binding affinity to plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM14917(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  3nMAssay Description:Binding affinity to plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13778(2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(...)
Affinity DataKi:  3nMAssay Description:Binding affinity to factor7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187179((S)-benzyl 1-(5-(4-((3-phenylpropyl)carbamoyl)benz...)
Affinity DataKi:  3nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101880(CHEMBL416127 | [3-(3-Benzyl-5-carbamimidoyl-1H-ind...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50186211(CHEMBL211482 | N-[3'-(5-carbamimidoyl-1H-indol-2-y...)
Affinity DataKi:  3nMAssay Description:Binding affinity to f7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13778(2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(...)
Affinity DataKi:  3nMAssay Description:Binding affinity for factor VIIa/TFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14312(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)
Affinity DataKi:  3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101879(CHEMBL50924 | [3-(3-Benzyl-5-carbamimidoyl-1H-indo...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187154((S)-benzyl 1-(5-(4-(phenethylcarbamoyl)benzyl)-1,2...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity of the compound towards PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14354(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-(di...)
Affinity DataKi:  3.20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187157((S)-benzyl 1-(5-(4-((3,5-difluorophenethyl)carbamo...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187165((S)-benzyl 1-(5-(4-(cinnamylcarbamoyl)benzyl)-1,2,...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187158((S)-benzyl 1-(5-(4-((2,3-dihydro-1H-inden-2-yl)car...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM13778(2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14898(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14311(CRA22 | N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-i...)
Affinity DataKi:  4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101870(3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-bromo...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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