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Found 649 with Last Name = 'thatcher' and Initial = 'gr'
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090462(CHEMBL3581693)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233215(CHEMBL4070169)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233203(CHEMBL4098867)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233205(CHEMBL4059888)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233202(CHEMBL4092208)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233204(CHEMBL4094499)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539805(CHEMBL4644032 | US11840533, Compound 72)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539805(CHEMBL4644032 | US11840533, Compound 72)
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640358(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640358(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640357(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640357(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640356(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM640356(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPapain(Carica papaya)
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437951(CHEMBL2408922 | US9403843, 24a)
Affinity DataKi:  1.62E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437950(CHEMBL2408917)
Affinity DataKi:  2.59E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM240262(US9403843, 33)
Affinity DataKi:  2.60E+3nM ΔG°:  -32.4kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437948(CHEMBL2408899 | US9403843, 50)
Affinity DataKi:  2.89E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437948(CHEMBL2408899 | US9403843, 50)
Affinity DataKi:  2.90E+3nM ΔG°:  -32.1kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437949(CHEMBL2408918 | US9403843, 34)
Affinity DataKi:  3.50E+3nM ΔG°:  -31.7kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437949(CHEMBL2408918 | US9403843, 34)
Affinity DataKi:  3.53E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataKi:  3.96E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM240232(US9403843, E64)
Affinity DataKi:  4.00E+3nM ΔG°:  -31.3kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetPapain(Carica papaya)
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataKi:  5.08E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437950(CHEMBL2408917)
Affinity DataKi:  5.31E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437951(CHEMBL2408922 | US9403843, 24a)
Affinity DataKi:  6.00E+3nM ΔG°:  -30.3kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437951(CHEMBL2408922 | US9403843, 24a)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437949(CHEMBL2408918 | US9403843, 34)
Affinity DataKi:  9.70E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50437948(CHEMBL2408899 | US9403843, 50)
Affinity DataKi:  1.92E+4nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514279(CHEMBL4527655)
Affinity DataIC50:  0.257nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514280(CHEMBL4586663)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50444892(CHEMBL392916)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at ER-alpha in human MCF-7:WS8 cells transfected with an estrogen response element assessed as suppression of estrogen-induced re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514280(CHEMBL4586663)
Affinity DataIC50:  0.708nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514287(CHEMBL4532671)
Affinity DataIC50:  0.955nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514292(CHEMBL4533964)
Affinity DataIC50:  1nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514293(CHEMBL4515212)
Affinity DataIC50:  1nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514283(CHEMBL4524872)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514282(CHEMBL4543096)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514284(CHEMBL4483006)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514287(CHEMBL4532671)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataIC50:  1.70nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 2 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514279(CHEMBL4527655)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514281(CHEMBL4516021)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514286(CHEMBL4448178)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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