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39 similar compounds to monomer 50299148

Compile data set for download or QSAR
Wt: 442.5
BDBM106984
Wt: 500.5
BDBM106985
Wt: 421.4
BDBM106987
Wt: 421.4
BDBM106988
Wt: 435.5
BDBM106989
Wt: 435.5
BDBM106990
Wt: 435.5
BDBM106991
Wt: 421.4
BDBM106992
Wt: 407.4
BDBM106993
Wt: 435.5
BDBM106994
Wt: 465.5
BDBM106997
Wt: 435.5
BDBM106998
Wt: 520.6
BDBM106999
Wt: 461.4
BDBM107000
Purchase
Wt: 449.5
BDBM107001
Displayed 1 to 15 (of 39 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 106984,106985,106987,106988,106989,106990,106991,106992,106993,106994,106997,106998,106999,107000,107001   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106984
PNG
(US8592579, 10)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C24H26N8O/c33-23(25-15-16-6-2-1-3-7-16)20-9-4-12-31(20)24-27-22(19-8-5-13-32(19)30-24)26-21-14-18(28-29-21)17-10-11-17/h1-3,5-8,13-14,17,20H,4,9-12,15H2,(H,25,33)(H2,26,27,28,29,30)/t20-/m1/s1
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n/an/a 3.17E+3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM107001
PNG
(US8592579, 105)
Show SMILES C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1nccs1
Show InChI InChI=1S/C21H23N9OS/c1-21(18(31)25-20-22-8-11-32-20)7-3-9-29(21)19-24-17(15-4-2-10-30(15)28-19)23-16-12-14(26-27-16)13-5-6-13/h2,4,8,10-13H,3,5-7,9H2,1H3,(H,22,25,31)(H2,23,24,26,27,28)/t21-/m0/s1
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n/an/a 4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106987
PNG
(US8592579, 41)
Show SMILES N[C@H]1CCN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C21H27N9O/c22-14-7-10-28(12-14)20(31)17-4-1-8-29(17)21-24-19(16-3-2-9-30(16)27-21)23-18-11-15(25-26-18)13-5-6-13/h2-3,9,11,13-14,17H,1,4-8,10,12,22H2,(H2,23,24,25,26,27)/t14-,17-/m0/s1
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n/an/a 122n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106988
PNG
(US8592579, 44)
Show SMILES O=C(NC1CCNC1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C21H27N9O/c31-20(23-14-7-8-22-12-14)17-4-1-9-29(17)21-25-19(16-3-2-10-30(16)28-21)24-18-11-15(26-27-18)13-5-6-13/h2-3,10-11,13-14,17,22H,1,4-9,12H2,(H,23,31)(H2,24,25,26,27,28)/t14?,17-/m0/s1
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n/an/a 98n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106989
PNG
(US8592579, 47)
Show SMILES N[C@@H]1CCCN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C22H29N9O/c23-15-4-1-9-29(13-15)21(32)18-6-2-10-30(18)22-25-20(17-5-3-11-31(17)28-22)24-19-12-16(26-27-19)14-7-8-14/h3,5,11-12,14-15,18H,1-2,4,6-10,13,23H2,(H2,24,25,26,27,28)/t15-,18+/m1/s1
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n/an/a 361n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106990
PNG
(US8592579, 55)
Show SMILES O=C(NC1CCCNC1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C22H29N9O/c32-21(24-15-4-1-9-23-13-15)18-6-2-10-30(18)22-26-20(17-5-3-11-31(17)29-22)25-19-12-16(27-28-19)14-7-8-14/h3,5,11-12,14-15,18,23H,1-2,4,6-10,13H2,(H,24,32)(H2,25,26,27,28,29)/t15?,18-/m0/s1
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n/an/a 72n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106991
PNG
(US8592579, 56)
Show SMILES O=C([C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)N1CCCNCC1
Show InChI InChI=1S/C22H29N9O/c32-21(29-10-3-8-23-9-13-29)18-5-1-11-30(18)22-25-20(17-4-2-12-31(17)28-22)24-19-14-16(26-27-19)15-6-7-15/h2,4,12,14-15,18,23H,1,3,5-11,13H2,(H2,24,25,26,27,28)/t18-/m0/s1
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n/an/a 2.84E+3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106992
PNG
(US8592579, 57)
Show SMILES O=C([C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)N1CCNCC1
Show InChI InChI=1S/C21H27N9O/c31-20(28-11-7-22-8-12-28)17-4-1-9-29(17)21-24-19(16-3-2-10-30(16)27-21)23-18-13-15(25-26-18)14-5-6-14/h2-3,10,13-14,17,22H,1,4-9,11-12H2,(H2,23,24,25,26,27)/t17-/m0/s1
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n/an/a 1.52E+3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106993
PNG
(US8592579, 58)
Show SMILES NC1CN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C20H25N9O/c21-13-10-27(11-13)19(30)16-4-1-7-28(16)20-23-18(15-3-2-8-29(15)26-20)22-17-9-14(24-25-17)12-5-6-12/h2-3,8-9,12-13,16H,1,4-7,10-11,21H2,(H2,22,23,24,25,26)/t16-/m0/s1
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n/an/a 174n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106994
PNG
(US8592579, 59)
Show SMILES NC[C@H]1CCCN1C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C22H29N9O/c23-13-15-4-1-9-29(15)21(32)18-6-2-10-30(18)22-25-20(17-5-3-11-31(17)28-22)24-19-12-16(26-27-19)14-7-8-14/h3,5,11-12,14-15,18H,1-2,4,6-10,13,23H2,(H2,24,25,26,27,28)/t15-,18+/m1/s1
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n/an/a 880n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106997
PNG
(US8592579, 71)
Show SMILES CC(C)(C)c1cc(Nc2nc(nn3cccc23)N2CCC[C@@]2(C)C(=O)NC2CCCNC2)[nH]n1
Show InChI InChI=1S/C24H35N9O/c1-23(2,3)18-14-19(30-29-18)27-20-17-9-6-13-33(17)31-22(28-20)32-12-7-10-24(32,4)21(34)26-16-8-5-11-25-15-16/h6,9,13-14,16,25H,5,7-8,10-12,15H2,1-4H3,(H,26,34)(H2,27,28,29,30,31)/t16?,24-/m0/s1
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n/an/a 428n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106998
PNG
(US8592579, 75)
Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)NC1CCNC1
Show InChI InChI=1S/C22H29N9O/c1-22(20(32)24-15-7-9-23-13-15)8-3-10-30(22)21-26-19(17-4-2-11-31(17)29-21)25-18-12-16(27-28-18)14-5-6-14/h2,4,11-12,14-15,23H,3,5-10,13H2,1H3,(H,24,32)(H2,25,26,27,28,29)/t15?,22-/m0/s1
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n/an/a 462n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106999
PNG
(US8592579, 97)
Show SMILES CC(C)(N)C(=O)N1CCCC(C1)NC(=O)[C@@H]1CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1
Show InChI InChI=1S/C26H36N10O2/c1-26(2,27)24(38)34-11-3-6-17(15-34)28-23(37)20-8-4-12-35(20)25-30-22(19-7-5-13-36(19)33-25)29-21-14-18(31-32-21)16-9-10-16/h5,7,13-14,16-17,20H,3-4,6,8-12,15,27H2,1-2H3,(H,28,37)(H2,29,30,31,32,33)/t17?,20-/m0/s1
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n/an/a 58n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM107000
PNG
(US8592579, 104)
Show SMILES C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1
Show InChI InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM106985
PNG
(US8592579, 23)
Show SMILES CCOC(=O)c1ccc(NC(=O)[C@@H]2CCCN2c2nc(Nc3cc([nH]n3)C3CC3)c3cccn3n2)cc1
Show InChI InChI=1S/C26H28N8O3/c1-2-37-25(36)17-9-11-18(12-10-17)27-24(35)21-6-3-13-33(21)26-29-23(20-5-4-14-34(20)32-26)28-22-15-19(30-31-22)16-7-8-16/h4-5,9-12,14-16,21H,2-3,6-8,13H2,1H3,(H,27,35)(H2,28,29,30,31,32)/t21-/m0/s1
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n/an/a 1.76E+3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Kinase assay using IGF1-receptor.


US Patent US8592579 (2013)


BindingDB Entry DOI: 10.7270/Q2SQ8Z12
More data for this
Ligand-Target Pair