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11 similar compounds to monomer 50452635

Compile data set for download or QSAR
Wt: 455.4
BDBM50011210
Wt: 455.4
BDBM50014345
Wt: 447.5
BDBM50014346
Wt: 483.4
BDBM50014349
Wt: 483.4
BDBM50014353
Wt: 438.4
BDBM50014354
Wt: 483.4
BDBM50014356
Wt: 437.4
BDBM50014358
Wt: 419.4
BDBM50014361
Wt: 469.4
BDBM50014362
Wt: 483.4
BDBM50014365

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50011210,50014345,50014346,50014349,50014353,50014354,50014356,50014358,50014361,50014362,50014365   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)


(Homo sapiens (Human))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in adrenal cell preparation


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in HepG2 cells


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA synthase


(Rattus norvegicus)
BDBM50014354
PNG
(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H]1C[C@@H](O)CC(=O)O1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H20F2N4O3/c1-29-23(26-27-28-29)20(11-10-19-12-18(30)13-21(31)32-19)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30H,12-13H2,1H3/b11-10+/t18-,19-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Bristol Myers Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of rat liver microsomal HMG-CoA reductase activity


J Med Chem 32: 2038-41 (1989)


Article DOI: 10.1021/jm00129a004
BindingDB Entry DOI: 10.7270/Q28S4NXH
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in spleen cell preparation


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Mus musculus)
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for inhibitory activity against isolated enzyme HMG-CoA reductase


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50011210
PNG
(CHEMBL342422 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Show SMILES Cn1nnnc1C(\C=C\C(O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18?,19-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductase


Bioorg Med Chem Lett 2: 99-104 (1992)


Article DOI: 10.1016/S0960-894X(00)80665-4
BindingDB Entry DOI: 10.7270/Q2X92B57
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014346
PNG
(CHEMBL441642 | Sodium; 3,5-dihydroxy-8-(1-methyl-1...)
Show SMILES Cc1ccc(cc1)C(=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1nnnn1C)c1ccc(C)cc1
Show InChI InChI=1S/C25H28N4O4/c1-16-4-8-18(9-5-16)24(19-10-6-17(2)7-11-19)22(25-26-27-28-29(25)3)13-12-20(30)14-21(31)15-23(32)33/h4-13,20-21,30-31H,14-15H2,1-3H3,(H,32,33)/p-1/b13-12+/t20-,21-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014349
PNG
(CHEMBL328846 | Sodium; 9,9-bis-(2-fluoro-4-methyl-...)
Show SMILES Cc1ccc(C(=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c2nnnn2C)c2ccc(C)cc2F)c(F)c1
Show InChI InChI=1S/C25H26F2N4O4/c1-14-4-7-18(21(26)10-14)24(19-8-5-15(2)11-22(19)27)20(25-28-29-30-31(25)3)9-6-16(32)12-17(33)13-23(34)35/h4-11,16-17,32-33H,12-13H2,1-3H3,(H,34,35)/p-1/b9-6+/t16-,17-/m1/s1
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n/an/a 580n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014353
PNG
(CHEMBL319739 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Show SMILES CC(C)n1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C25H26F2N4O4/c1-15(2)31-25(28-29-30-31)22(12-11-20(32)13-21(33)14-23(34)35)24(16-3-7-18(26)8-4-16)17-5-9-19(27)10-6-17/h3-12,15,20-21,32-33H,13-14H2,1-2H3,(H,34,35)/p-1/b12-11+/t20-,21-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014356
PNG
(CHEMBL320666 | Sodium; 9,9-bis-(4-fluoro-2-methyl-...)
Show SMILES Cc1cc(F)ccc1C(=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1nnnn1C)c1ccc(F)cc1C
Show InChI InChI=1S/C25H26F2N4O4/c1-14-10-16(26)4-7-20(14)24(21-8-5-17(27)11-15(21)2)22(25-28-29-30-31(25)3)9-6-18(32)12-19(33)13-23(34)35/h4-11,18-19,32-33H,12-13H2,1-3H3,(H,34,35)/p-1/b9-6+/t18-,19-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014354
PNG
(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H]1C[C@@H](O)CC(=O)O1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H20F2N4O3/c1-29-23(26-27-28-29)20(11-10-19-12-18(30)13-21(31)32-19)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30H,12-13H2,1H3/b11-10+/t18-,19-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporation


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014358
PNG
(CHEMBL103192 | Sodium; 9-(4-fluoro-phenyl)-3,5-dih...)
Show SMILES Cn1nnnc1\C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(/c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H23FN4O4/c1-28-23(25-26-27-28)20(12-11-18(29)13-19(30)14-21(31)32)22(15-5-3-2-4-6-15)16-7-9-17(24)10-8-16/h2-12,18-19,29-30H,13-14H2,1H3,(H,31,32)/p-1/b12-11+,22-20+/t18-,19-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014362
PNG
(CHEMBL103661 | Sodium; 8-(1-ethyl-1H-tetrazol-5-yl...)
Show SMILES CCn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H24F2N4O4/c1-2-30-24(27-28-29-30)21(12-11-19(31)13-20(32)14-22(33)34)23(15-3-7-17(25)8-4-15)16-5-9-18(26)10-6-16/h3-12,19-20,31-32H,2,13-14H2,1H3,(H,33,34)/p-1/b12-11+/t19-,20-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014361
PNG
(CHEMBL318754 | Sodium; 3,5-dihydroxy-8-(1-methyl-1...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H24N4O4/c1-27-23(24-25-26-27)20(13-12-18(28)14-19(29)15-21(30)31)22(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-13,18-19,28-29H,14-15H2,1H3,(H,30,31)/p-1/b13-12+/t18-,19-/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014365
PNG
(CHEMBL103547 | Sodium; 9,9-bis-(4-fluoro-3-methyl-...)
Show SMILES Cc1cc(ccc1F)C(=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1nnnn1C)c1ccc(F)c(C)c1
Show InChI InChI=1S/C25H26F2N4O4/c1-14-10-16(4-8-21(14)26)24(17-5-9-22(27)15(2)11-17)20(25-28-29-30-31(25)3)7-6-18(32)12-19(33)13-23(34)35/h4-11,18-19,32-33H,12-13H2,1-3H3,(H,34,35)/p-1/b7-6+/t18-,19-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was measured against rat liver HMG-CoA reductase


J Med Chem 33: 2982-99 (1990)


Article DOI: 10.1021/jm00173a013
BindingDB Entry DOI: 10.7270/Q26T0N7R
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in liver cell preparation


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Homo sapiens (Human))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against rat hepatocyte


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in bovine occular cell preparation


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Homo sapiens (Human))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against HMG-CoA reductase in testes cell preparation


Bioorg Med Chem Lett 2: 1085-1088 (1992)


Article DOI: 10.1016/S0960-894X(00)80623-X
BindingDB Entry DOI: 10.7270/Q2NG4QJQ
More data for this
Ligand-Target Pair
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50014345
PNG
(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Show SMILES Cn1nnnc1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22F2N4O4/c1-29-23(26-27-28-29)20(11-10-18(30)12-19(31)13-21(32)33)22(14-2-6-16(24)7-3-14)15-4-8-17(25)9-5-15/h2-11,18-19,30-31H,12-13H2,1H3,(H,32,33)/p-1/b11-10+/t18-,19-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver.


J Med Chem 34: 463-6 (1991)


Article DOI: 10.1021/jm00105a071
BindingDB Entry DOI: 10.7270/Q2MS3TC4
More data for this
Ligand-Target Pair