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34 similar compounds to monomer 50386381

Compile data set for download or QSAR
Wt: 335.4
BDBM50454930
Wt: 335.4
BDBM50454931
Wt: 275.4
BDBM50045744
Wt: 259.3
BDBM50045751
Wt: 275.4
BDBM50045787
Wt: 233.3
BDBM50045768
Wt: 303.4
BDBM50045770
Wt: 219.3
BDBM50045772
Wt: 337.4
BDBM50045773
Wt: 315.4
BDBM50045778
Wt: 289.4
BDBM50045779
Wt: 303.4
BDBM50045784
Wt: 329.5
BDBM50045785
Wt: 289.4
BDBM50045788
Wt: 303.4
BDBM50045789
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50454930,50454931,50045744,50045751,50045787,50045768,50045770,50045772,50045773,50045778,50045779,50045784,50045785,50045788,50045789   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045779
PNG
(3-[3,4-Dimethyl-1-(4-methyl-pentyl)-piperidin-4-yl...)
Show SMILES CC(C)CCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C19H31NO/c1-15(2)7-6-11-20-12-10-19(4,16(3)14-20)17-8-5-9-18(21)13-17/h5,8-9,13,15-16,21H,6-7,10-12,14H2,1-4H3/t16-,19+/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045784
PNG
((3R,4R)3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidi...)
Show SMILES CC(C)CCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m0/s1
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0.460n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045785
PNG
(3-[1-(3-Cyclohexyl-propyl)-3,4-dimethyl-piperidin-...)
Show SMILES C[C@H]1CN(CCCC2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C22H35NO/c1-18-17-23(14-7-10-19-8-4-3-5-9-19)15-13-22(18,2)20-11-6-12-21(24)16-20/h6,11-12,16,18-19,24H,3-5,7-10,13-15,17H2,1-2H3/t18-,22+/m0/s1
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0.490n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045773
PNG
(3-[3,4-Dimethyl-1-(3-o-tolyl-propyl)-piperidin-4-y...)
Show SMILES C[C@H]1CN(CCCc2ccccc2C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H31NO/c1-18-8-4-5-9-20(18)10-7-14-24-15-13-23(3,19(2)17-24)21-11-6-12-22(25)16-21/h4-6,8-9,11-12,16,19,25H,7,10,13-15,17H2,1-3H3/t19-,23+/m0/s1
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0.620n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045770
PNG
(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-4-5-6-7-8-13-21-14-12-20(3,17(2)16-21)18-10-9-11-19(22)15-18/h9-11,15,17,22H,4-8,12-14,16H2,1-3H3/t17-,20+/m0/s1
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0.620n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045770
PNG
(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-4-5-6-7-8-13-21-14-12-20(3,17(2)16-21)18-10-9-11-19(22)15-18/h9-11,15,17,22H,4-8,12-14,16H2,1-3H3/t17-,20+/m0/s1
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0.620n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045778
PNG
(3-[1-(2-Cyclohexyl-ethyl)-3,4-dimethyl-piperidin-4...)
Show SMILES C[C@H]1CN(CCC2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C21H33NO/c1-17-16-22(13-11-18-7-4-3-5-8-18)14-12-21(17,2)19-9-6-10-20(23)15-19/h6,9-10,15,17-18,23H,3-5,7-8,11-14,16H2,1-2H3/t17-,21+/m0/s1
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0.650n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045784
PNG
((3R,4R)3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidi...)
Show SMILES CC(C)CCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m0/s1
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0.890n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045789
PNG
(3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidin-4-yl]...)
Show SMILES CC(C)CCCCN1CC[C@@](C)([C@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50454931
PNG
(CHEMBL2113735)
Show SMILES C[C@H]1CN(C[C@@H]2C[C@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19-,22-,23+/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045784
PNG
((3R,4R)3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidi...)
Show SMILES CC(C)CCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045785
PNG
(3-[1-(3-Cyclohexyl-propyl)-3,4-dimethyl-piperidin-...)
Show SMILES C[C@H]1CN(CCCC2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C22H35NO/c1-18-17-23(14-7-10-19-8-4-3-5-9-19)15-13-22(18,2)20-11-6-12-21(24)16-20/h6,11-12,16,18-19,24H,3-5,7-10,13-15,17H2,1-2H3/t18-,22+/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045778
PNG
(3-[1-(2-Cyclohexyl-ethyl)-3,4-dimethyl-piperidin-4...)
Show SMILES C[C@H]1CN(CCC2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C21H33NO/c1-17-16-22(13-11-18-7-4-3-5-8-18)14-12-21(17,2)19-9-6-10-20(23)15-19/h6,9-10,15,17-18,23H,3-5,7-8,11-14,16H2,1-2H3/t17-,21+/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045789
PNG
(3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidin-4-yl]...)
Show SMILES CC(C)CCCCN1CC[C@@](C)([C@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m1/s1
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3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045744
PNG
(3-(3,4-Dimethyl-1-pentyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-4-5-6-11-19-12-10-18(3,15(2)14-19)16-8-7-9-17(20)13-16/h7-9,13,15,20H,4-6,10-12,14H2,1-3H3/t15-,18+/m0/s1
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4.30n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045744
PNG
(3-(3,4-Dimethyl-1-pentyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-4-5-6-11-19-12-10-18(3,15(2)14-19)16-8-7-9-17(20)13-16/h7-9,13,15,20H,4-6,10-12,14H2,1-3H3/t15-,18+/m0/s1
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4.30n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045788
PNG
((3S,4S)3-(1-Hexyl-3,4-dimethyl-piperidin-4-yl)-phe...)
Show SMILES CCCCCCN1CC[C@@](C)([C@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C19H31NO/c1-4-5-6-7-12-20-13-11-19(3,16(2)15-20)17-9-8-10-18(21)14-17/h8-10,14,16,21H,4-7,11-13,15H2,1-3H3/t16-,19+/m1/s1
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5.60n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045788
PNG
((3S,4S)3-(1-Hexyl-3,4-dimethyl-piperidin-4-yl)-phe...)
Show SMILES CCCCCCN1CC[C@@](C)([C@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C19H31NO/c1-4-5-6-7-12-20-13-11-19(3,16(2)15-20)17-9-8-10-18(21)14-17/h8-10,14,16,21H,4-7,11-13,15H2,1-3H3/t16-,19+/m1/s1
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5.80n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045784
PNG
((3R,4R)3-[3,4-Dimethyl-1-(5-methyl-hexyl)-piperidi...)
Show SMILES CC(C)CCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-16(2)8-5-6-12-21-13-11-20(4,17(3)15-21)18-9-7-10-19(22)14-18/h7,9-10,14,16-17,22H,5-6,8,11-13,15H2,1-4H3/t17-,20+/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045773
PNG
(3-[3,4-Dimethyl-1-(3-o-tolyl-propyl)-piperidin-4-y...)
Show SMILES C[C@H]1CN(CCCc2ccccc2C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H31NO/c1-18-8-4-5-9-20(18)10-7-14-24-15-13-23(3,19(2)17-24)21-11-6-12-22(25)16-21/h4-6,8-9,11-12,16,19,25H,7,10,13-15,17H2,1-3H3/t19-,23+/m0/s1
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8.90n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045779
PNG
(3-[3,4-Dimethyl-1-(4-methyl-pentyl)-piperidin-4-yl...)
Show SMILES CC(C)CCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C19H31NO/c1-15(2)7-6-11-20-12-10-19(4,16(3)14-20)17-8-5-9-18(21)13-17/h5,8-9,13,15-16,21H,6-7,10-12,14H2,1-4H3/t16-,19+/m0/s1
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9.60n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045768
PNG
(3-(1-Ethyl-3,4-dimethyl-piperidin-4-yl)-phenol | C...)
Show SMILES CCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C15H23NO/c1-4-16-9-8-15(3,12(2)11-16)13-6-5-7-14(17)10-13/h5-7,10,12,17H,4,8-9,11H2,1-3H3/t12-,15+/m0/s1
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18n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045751
PNG
(3-(1-Cyclopropylmethyl-3,4-dimethyl-piperidin-4-yl...)
Show SMILES C[C@H]1CN(CC2CC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C17H25NO/c1-13-11-18(12-14-6-7-14)9-8-17(13,2)15-4-3-5-16(19)10-15/h3-5,10,13-14,19H,6-9,11-12H2,1-2H3/t13-,17+/m0/s1
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21n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045787
PNG
(3-[3,4-Dimethyl-1-(3-methyl-butyl)-piperidin-4-yl]...)
Show SMILES CC(C)CCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-14(2)8-10-19-11-9-18(4,15(3)13-19)16-6-5-7-17(20)12-16/h5-7,12,14-15,20H,8-11,13H2,1-4H3/t15-,18+/m0/s1
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32n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045751
PNG
(3-(1-Cyclopropylmethyl-3,4-dimethyl-piperidin-4-yl...)
Show SMILES C[C@H]1CN(CC2CC2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C17H25NO/c1-13-11-18(12-14-6-7-14)9-8-17(13,2)15-4-3-5-16(19)10-15/h3-5,10,13-14,19H,6-9,11-12H2,1-2H3/t13-,17+/m0/s1
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36n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at 100 nM from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045744
PNG
(3-(3,4-Dimethyl-1-pentyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-4-5-6-11-19-12-10-18(3,15(2)14-19)16-8-7-9-17(20)13-16/h7-9,13,15,20H,4-6,10-12,14H2,1-3H3/t15-,18+/m0/s1
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44n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at 10 nM from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045768
PNG
(3-(1-Ethyl-3,4-dimethyl-piperidin-4-yl)-phenol | C...)
Show SMILES CCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C15H23NO/c1-4-16-9-8-15(3,12(2)11-16)13-6-5-7-14(17)10-13/h5-7,10,12,17H,4,8-9,11H2,1-3H3/t12-,15+/m0/s1
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52n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50454930
PNG
(CHEMBL2113734)
Show SMILES C[C@H]1CN(C[C@H]2C[C@@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19+,22+,23+/m0/s1
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56n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045770
PNG
(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-4-5-6-7-8-13-21-14-12-20(3,17(2)16-21)18-10-9-11-19(22)15-18/h9-11,15,17,22H,4-8,12-14,16H2,1-3H3/t17-,20+/m0/s1
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57n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at 10 nM from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045787
PNG
(3-[3,4-Dimethyl-1-(3-methyl-butyl)-piperidin-4-yl]...)
Show SMILES CC(C)CCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-14(2)8-10-19-11-9-18(4,15(3)13-19)16-6-5-7-17(20)12-16/h5-7,12,14-15,20H,8-11,13H2,1-4H3/t15-,18+/m0/s1
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70n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045744
PNG
(3-(3,4-Dimethyl-1-pentyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C18H29NO/c1-4-5-6-11-19-12-10-18(3,15(2)14-19)16-8-7-9-17(20)13-16/h7-9,13,15,20H,4-6,10-12,14H2,1-3H3/t15-,18+/m0/s1
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78n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by displacement of [3H]-NAL at 10 nM from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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80n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligand


Bioorg Med Chem Lett 8: 3149-52 (1999)


Article DOI: 10.1016/s0960-894x(98)00576-9
BindingDB Entry DOI: 10.7270/Q2S75FGQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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80n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor mu 1 using [3H]-Naloxone as radioligand.


J Med Chem 41: 4143-9 (1998)


Article DOI: 10.1021/jm980290i
BindingDB Entry DOI: 10.7270/Q2RB73Q6
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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80n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenates


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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80n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenates


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50454931
PNG
(CHEMBL2113735)
Show SMILES C[C@H]1CN(C[C@@H]2C[C@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19-,22-,23+/m0/s1
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82n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 of guinea pig membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045770
PNG
(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Show SMILES CCCCCCCN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1
Show InChI InChI=1S/C20H33NO/c1-4-5-6-7-8-13-21-14-12-20(3,17(2)16-21)18-10-9-11-19(22)15-18/h9-11,15,17,22H,4-8,12-14,16H2,1-3H3/t17-,20+/m0/s1
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87n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at 10 nM from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50454930
PNG
(CHEMBL2113734)
Show SMILES C[C@H]1CN(C[C@H]2C[C@@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19+,22+,23+/m0/s1
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388n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 of guinea pig membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50454931
PNG
(CHEMBL2113735)
Show SMILES C[C@H]1CN(C[C@@H]2C[C@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19-,22-,23+/m0/s1
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709n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50454930
PNG
(CHEMBL2113734)
Show SMILES C[C@H]1CN(C[C@H]2C[C@@H]2c2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C23H29NO/c1-17-15-24(16-19-13-22(19)18-7-4-3-5-8-18)12-11-23(17,2)20-9-6-10-21(25)14-20/h3-10,14,17,19,22,25H,11-13,15-16H2,1-2H3/t17-,19+,22+,23+/m0/s1
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827n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranes


J Med Chem 41: 1980-90 (1998)


Article DOI: 10.1021/jm980063g
BindingDB Entry DOI: 10.7270/Q2K35SSN
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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833n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor kappa 1 using [3H]-Ethylketocyclazocine as radioligand.


J Med Chem 41: 4143-9 (1998)


Article DOI: 10.1021/jm980290i
BindingDB Entry DOI: 10.7270/Q2RB73Q6
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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833n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissue


J Med Chem 36: 2842-50 (1993)


Article DOI: 10.1021/jm00072a002
BindingDB Entry DOI: 10.7270/Q2R78D9W
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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833n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue


J Med Chem 36: 2833-41 (1993)


Article DOI: 10.1021/jm00072a001
BindingDB Entry DOI: 10.7270/Q2W0951M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50045772
PNG
(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Show SMILES C[C@H]1CN(C)CC[C@@]1(C)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-11-10-15(3)8-7-14(11,2)12-5-4-6-13(16)9-12/h4-6,9,11,16H,7-8,10H2,1-3H3/t11-,14+/m0/s1
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833n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined against Opioid receptor kappa 1
using [3H]-Ethylketocyclazocine as radioligand


Bioorg Med Chem Lett 8: 3149-52 (1999)


Article DOI: 10.1016/s0960-894x(98)00576-9
BindingDB Entry DOI: 10.7270/Q2S75FGQ
More data for this
Ligand-Target Pair