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6 similar compounds to monomer 50149203

Compile data set for download or QSAR
Wt: 248.1
BDBM50057754
Wt: 248.1
BDBM50102880
Wt: 248.1
BDBM50102884
Wt: 248.1
BDBM50211296
Wt: 248.1
BDBM50263768
Wt: 248.1
BDBM50363875

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50057754,50102880,50102884,50211296,50263768,50363875   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50057754
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1OC2(NC(=O)NC2=O)C(O)C(O)C1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)
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3.00E+3n/an/an/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of rabbit glycogen phosphorylase B enzyme


J Med Chem 40: 1455-64 (1997)


Article DOI: 10.1021/jm9608016
BindingDB Entry DOI: 10.7270/Q26T0N9N
More data for this
Ligand-Target Pair
Muscle glycogen phosphorylase


(Homo sapiens (Human))
BDBM50057754
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1OC2(NC(=O)NC2=O)C(O)C(O)C1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)
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3.02E+3n/an/an/an/an/an/an/an/a



University of Alcala

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit muscle glycogen phosphorylase


J Med Chem 40: 4089-102 (1998)

Checked by Author
Article DOI: 10.1021/jm970273d
BindingDB Entry DOI: 10.7270/Q2S46TGM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102880
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8+/m1/s1
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3.10E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50263768
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8+/m1/s1
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3.10E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b


Bioorg Med Chem Lett 18: 5680-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.052
BindingDB Entry DOI: 10.7270/Q2571BTV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50263768
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8+/m1/s1
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3.10E+3n/an/an/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b in presence of glucose 1-phosphate


Eur J Med Chem 108: 444-54 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.004
BindingDB Entry DOI: 10.7270/Q2QR500M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50263768
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8+/m1/s1
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3.10E+3n/an/an/an/an/an/a6.8n/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.8


Bioorg Med Chem 20: 1801-16 (2012)


Article DOI: 10.1016/j.bmc.2011.12.059
BindingDB Entry DOI: 10.7270/Q2SN09DD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50211296
PNG
((7R,8S,9S,10R)-8,9,10-trihydroxy-7-hydroxymethyl-6...)
Show SMILES OC[C@H]1OC2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8?/m1/s1
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4.20E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of liver glycogen phosphorylase B


Bioorg Med Chem 15: 4048-56 (2007)


Article DOI: 10.1016/j.bmc.2007.03.084
BindingDB Entry DOI: 10.7270/Q2XW4JGC
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102880
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8+/m1/s1
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4.20E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102880
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8+/m1/s1
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1.28E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against liver Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102880
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8+/m1/s1
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1.65E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against liver Glycogen Phosphorylase a


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102880
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8+/m1/s1
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2.60E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase a


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102884
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8-/m1/s1
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1.05E+5n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50363875
PNG
(CHEMBL595439)
Show SMILES OC[C@H]1O[C@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8-/m1/s1
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1.05E+5n/an/an/an/an/an/a6.8n/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.8


Bioorg Med Chem 20: 1801-16 (2012)


Article DOI: 10.1016/j.bmc.2011.12.059
BindingDB Entry DOI: 10.7270/Q2SN09DD
More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens (Human))
BDBM50102884
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1O[C@]2(NC(=O)NC2=O)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2?,3-,4+,5?,8-/m1/s1
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3.20E+5n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)


Article DOI: 10.1021/jm010892t
BindingDB Entry DOI: 10.7270/Q2NV9JZQ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50363875
PNG
(CHEMBL595439)
Show SMILES OC[C@H]1O[C@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8-/m1/s1
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3.20E+5n/an/an/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b in presence of glucose 1-phosphate


Eur J Med Chem 108: 444-54 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.004
BindingDB Entry DOI: 10.7270/Q2QR500M
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50263768
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)/t2-,3-,4+,5-,8+/m1/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Binding affinity to rabbit muscular GPb by NMR binding assay


J Med Chem 55: 1287-95 (2012)


Article DOI: 10.1021/jm201439b
BindingDB Entry DOI: 10.7270/Q21J9BS9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)