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3 similar compounds to monomer 50293743

Compile data set for download or QSAR
Wt: 295.1
BDBM50124744
Wt: 267.1
BDBM50293732
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Wt: 351.7
BDBM50336614

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50124744,50293732,50336614   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50293732
PNG
(CHEMBL549330 | N-(3,4-dichlorophenyl)picolinamide ...)
Show SMILES Clc1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c13-9-5-4-8(7-10(9)14)16-12(17)11-3-1-2-6-15-11/h1-7H,(H,16,17)
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n/an/an/an/a 1.37E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2VT1QHF
More data for this
Ligand-Target Pair
glutamate receptor, metabotropic 4 precursor


(Rattus norvegicus)
BDBM50293732
PNG
(CHEMBL549330 | N-(3,4-dichlorophenyl)picolinamide ...)
Show SMILES Clc1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c13-9-5-4-8(7-10(9)14)16-12(17)11-3-1-2-6-15-11/h1-7H,(H,16,17)
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KEGG

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n/an/an/an/a 1.25E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2DR2SWV
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50336614
PNG
(CHEMBL1672244 | N-(4-benzamido-3-chlorophenyl)pico...)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1
Show InChI InChI=1S/C19H14ClN3O2/c20-15-12-14(22-19(25)17-8-4-5-11-21-17)9-10-16(15)23-18(24)13-6-2-1-3-7-13/h1-12H,(H,22,25)(H,23,24)
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PubMed
n/an/an/an/a 518n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50293732
PNG
(CHEMBL549330 | N-(3,4-dichlorophenyl)picolinamide ...)
Show SMILES Clc1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C12H8Cl2N2O/c13-9-5-4-8(7-10(9)14)16-12(17)11-3-1-2-6-15-11/h1-7H,(H,16,17)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization


J Med Chem 52: 4115-8 (2009)


Article DOI: 10.1021/jm9005065
BindingDB Entry DOI: 10.7270/Q2RJ4JHT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50336614
PNG
(CHEMBL1672244 | N-(4-benzamido-3-chlorophenyl)pico...)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1
Show InChI InChI=1S/C19H14ClN3O2/c20-15-12-14(22-19(25)17-8-4-5-11-21-17)9-10-16(15)23-18(24)13-6-2-1-3-7-13/h1-12H,(H,22,25)(H,23,24)
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n/an/an/an/a 361n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50124744
PNG
(6-Formyl-pyridine-2-carboxylic acid (3,4-dichloro-...)
Show SMILES Clc1ccc(NC(=O)c2cccc(C=O)n2)cc1Cl
Show InChI InChI=1S/C13H8Cl2N2O2/c14-10-5-4-8(6-11(10)15)17-13(19)12-3-1-2-9(7-18)16-12/h1-7H,(H,17,19)
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KEGG

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n/an/a>1.00E+5n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of compound against telomerase


Bioorg Med Chem Lett 13: 609-12 (2003)


Article DOI: 10.1016/s0960-894x(02)01041-7
BindingDB Entry DOI: 10.7270/Q23R0S7S
More data for this
Ligand-Target Pair