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36 similar compounds to monomer 50203376

Compile data set for download or QSAR
Wt: 362.4
BDBM50192167
Wt: 344.4
BDBM50192179
Purchase
Wt: 378.8
BDBM50192188
Wt: 358.4
BDBM50203372
Wt: 423.3
BDBM50203373
Wt: 358.4
BDBM50203374
Wt: 344.4
BDBM50203375
Purchase
Wt: 358.4
BDBM50203377
Wt: 378.8
BDBM50203378
Wt: 344.4
BDBM50203383
Purchase
Wt: 358.4
BDBM50203384
Wt: 412.4
BDBM50203385
Wt: 412.4
BDBM50203386
Wt: 378.8
BDBM50203389
Wt: 358.4
BDBM50203391
Displayed 1 to 15 (of 36 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50192167,50192179,50192188,50203372,50203373,50203374,50203375,50203377,50203378,50203383,50203384,50203385,50203386,50203389,50203391   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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11n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203374
PNG
(CHEMBL234825 | naphthalene-2-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H26N2O/c1-18-5-4-6-19(15-18)17-26-13-11-23(12-14-26)25-24(27)22-10-9-20-7-2-3-8-21(20)16-22/h2-10,15-16,23H,11-14,17H2,1H3,(H,25,27)
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11n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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11n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203377
PNG
(CHEMBL234647 | naphthalene-2-carboxylic acid [1-(2...)
Show SMILES Cc1ccccc1CN1CCC(CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-2-3-9-22(18)17-26-14-12-23(13-15-26)25-24(27)21-11-10-19-7-4-5-8-20(19)16-21/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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26n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203373
PNG
(CHEMBL234472 | N-(1-(4-bromobenzyl)piperidin-4-yl)...)
Show SMILES Brc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H23BrN2O/c24-21-9-5-17(6-10-21)16-26-13-11-22(12-14-26)25-23(27)20-8-7-18-3-1-2-4-19(18)15-20/h1-10,15,22H,11-14,16H2,(H,25,27)
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34n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203378
PNG
(CHEMBL233581 | N-(1-(4-chlorobenzyl)piperidin-4-yl...)
Show SMILES Clc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H23ClN2O/c24-21-9-5-17(6-10-21)16-26-13-11-22(12-14-26)25-23(27)20-8-7-18-3-1-2-4-19(18)15-20/h1-10,15,22H,11-14,16H2,(H,25,27)
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37n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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44n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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44n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203389
PNG
(CHEMBL233580 | N-(1-(3-chlorobenzyl)piperidin-4-yl...)
Show SMILES Clc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H23ClN2O/c24-21-7-3-4-17(14-21)16-26-12-10-22(11-13-26)25-23(27)20-9-8-18-5-1-2-6-19(18)15-20/h1-9,14-15,22H,10-13,16H2,(H,25,27)
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54n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203391
PNG
(CHEMBL233578 | naphthalene-1-carboxylic acid [1-(4...)
Show SMILES Cc1ccc(CN2CCC(CC2)NC(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C24H26N2O/c1-18-9-11-19(12-10-18)17-26-15-13-21(14-16-26)25-24(27)23-8-4-6-20-5-2-3-7-22(20)23/h2-12,21H,13-17H2,1H3,(H,25,27)
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69n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203384
PNG
(CHEMBL233404 | naphthalene-1-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2cccc3ccccc23)c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-4-7-19(16-18)17-26-14-12-21(13-15-26)25-24(27)23-11-5-9-20-8-2-3-10-22(20)23/h2-11,16,21H,12-15,17H2,1H3,(H,25,27)
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77n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203386
PNG
(CHEMBL430167 | N-(1-(4-(trifluoromethyl)benzyl)pip...)
Show SMILES FC(F)(F)c1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H23F3N2O/c25-24(26,27)21-9-5-17(6-10-21)16-29-13-11-22(12-14-29)28-23(30)20-8-7-18-3-1-2-4-19(18)15-20/h1-10,15,22H,11-14,16H2,(H,28,30)
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84n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203374
PNG
(CHEMBL234825 | naphthalene-2-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H26N2O/c1-18-5-4-6-19(15-18)17-26-13-11-23(12-14-26)25-24(27)22-10-9-20-7-2-3-8-21(20)16-22/h2-10,15-16,23H,11-14,17H2,1H3,(H,25,27)
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87n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203385
PNG
(CHEMBL234824 | N-(1-(4-(trifluoromethyl)benzyl)pip...)
Show SMILES FC(F)(F)c1ccc(CN2CCC(CC2)NC(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C24H23F3N2O/c25-24(26,27)19-10-8-17(9-11-19)16-29-14-12-20(13-15-29)28-23(30)22-7-3-5-18-4-1-2-6-21(18)22/h1-11,20H,12-16H2,(H,28,30)
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96n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192167
PNG
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)
Show SMILES Fc1ccc2cc(CN3CCC(CC3)NC(=O)c3ccccc3)ccc2c1
Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27)
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125n/an/an/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding activity against human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203389
PNG
(CHEMBL233580 | N-(1-(3-chlorobenzyl)piperidin-4-yl...)
Show SMILES Clc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H23ClN2O/c24-21-7-3-4-17(14-21)16-26-12-10-22(11-13-26)25-23(27)20-9-8-18-5-1-2-6-19(18)15-20/h1-9,14-15,22H,10-13,16H2,(H,25,27)
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133n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203372
PNG
(CHEMBL395632 | naphthalene-1-carboxylic acid [1-(2...)
Show SMILES Cc1ccccc1CN1CCC(CC1)NC(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N2O/c1-18-7-2-3-9-20(18)17-26-15-13-21(14-16-26)25-24(27)23-12-6-10-19-8-4-5-11-22(19)23/h2-12,21H,13-17H2,1H3,(H,25,27)
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155n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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162n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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162n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203377
PNG
(CHEMBL234647 | naphthalene-2-carboxylic acid [1-(2...)
Show SMILES Cc1ccccc1CN1CCC(CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-2-3-9-22(18)17-26-14-12-23(13-15-26)25-24(27)21-11-10-19-7-4-5-8-20(19)16-21/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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175n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203373
PNG
(CHEMBL234472 | N-(1-(4-bromobenzyl)piperidin-4-yl)...)
Show SMILES Brc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H23BrN2O/c24-21-9-5-17(6-10-21)16-26-13-11-22(12-14-26)25-23(27)20-8-7-18-3-1-2-4-19(18)15-20/h1-10,15,22H,11-14,16H2,(H,25,27)
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223n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192188
PNG
(4-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)
Show SMILES Clc1ccc(cc1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C23H23ClN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27)
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232n/an/an/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding activity against human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203378
PNG
(CHEMBL233581 | N-(1-(4-chlorobenzyl)piperidin-4-yl...)
Show SMILES Clc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H23ClN2O/c24-21-9-5-17(6-10-21)16-26-13-11-22(12-14-26)25-23(27)20-8-7-18-3-1-2-4-19(18)15-20/h1-10,15,22H,11-14,16H2,(H,25,27)
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242n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192179
PNG
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)
Show SMILES O=C(NC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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347n/an/an/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding activity against human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
Betaine transporter


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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1.50E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human BGT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 2


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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2.30E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT2 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 1


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 3


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192167
PNG
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)
Show SMILES Fc1ccc2cc(CN3CCC(CC3)NC(=O)c3ccccc3)ccc2c1
Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27)
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n/an/a 109n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192179
PNG
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)
Show SMILES O=C(NC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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n/an/a 948n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))
BDBM50192167
PNG
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)
Show SMILES Fc1ccc2cc(CN3CCC(CC3)NC(=O)c3ccccc3)ccc2c1
Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Astellas Pharma Inc

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx


Bioorg Med Chem 16: 144-56 (2008)


Article DOI: 10.1016/j.bmc.2007.10.003
BindingDB Entry DOI: 10.7270/Q2445NBG
More data for this
Ligand-Target Pair