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30 similar compounds to monomer 50218209

Compile data set for download or QSAR
Wt: 344.4
BDBM50192179
Purchase
Wt: 358.4
BDBM50203374
Wt: 344.4
BDBM50203375
Purchase
Wt: 358.4
BDBM50203376
Wt: 358.4
BDBM50203377
Wt: 344.4
BDBM50203383
Purchase
Wt: 358.4
BDBM50203384
Wt: 358.4
BDBM50203391
Wt: 386.5
BDBM50203466
Wt: 358.4
BDBM50203467
Wt: 344.4
BDBM50203468
Wt: 358.4
BDBM50203474
Wt: 358.4
BDBM50203478
Wt: 372.5
BDBM50203479
Wt: 254.3
BDBM50302312
Displayed 1 to 15 (of 30 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50192179,50203374,50203375,50203376,50203377,50203383,50203384,50203391,50203466,50203467,50203468,50203474,50203478,50203479,50302312   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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11n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203374
PNG
(CHEMBL234825 | naphthalene-2-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H26N2O/c1-18-5-4-6-19(15-18)17-26-13-11-23(12-14-26)25-24(27)22-10-9-20-7-2-3-8-21(20)16-22/h2-10,15-16,23H,11-14,17H2,1H3,(H,25,27)
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11n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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11n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203376
PNG
(CHEMBL234826 | naphthalene-2-carboxylic acid [1-(4...)
Show SMILES Cc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H26N2O/c1-18-6-8-19(9-7-18)17-26-14-12-23(13-15-26)25-24(27)22-11-10-20-4-2-3-5-21(20)16-22/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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21n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203377
PNG
(CHEMBL234647 | naphthalene-2-carboxylic acid [1-(2...)
Show SMILES Cc1ccccc1CN1CCC(CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-2-3-9-22(18)17-26-14-12-23(13-15-26)25-24(27)21-11-10-19-7-4-5-8-20(19)16-21/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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26n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203467
PNG
(CHEMBL229023 | N-(1-(1-phenylethyl)piperidin-4-yl)...)
Show SMILES CC(N1CCC(CC1)NC(=O)c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-18(19-7-3-2-4-8-19)26-15-13-23(14-16-26)25-24(27)22-12-11-20-9-5-6-10-21(20)17-22/h2-12,17-18,23H,13-16H2,1H3,(H,25,27)
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29n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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44n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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44n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203391
PNG
(CHEMBL233578 | naphthalene-1-carboxylic acid [1-(4...)
Show SMILES Cc1ccc(CN2CCC(CC2)NC(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C24H26N2O/c1-18-9-11-19(12-10-18)17-26-15-13-21(14-16-26)25-24(27)23-8-4-6-20-5-2-3-7-22(20)23/h2-12,21H,13-17H2,1H3,(H,25,27)
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69n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203384
PNG
(CHEMBL233404 | naphthalene-1-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2cccc3ccccc23)c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-4-7-19(16-18)17-26-14-12-21(13-15-26)25-24(27)23-11-5-9-20-8-2-3-10-22(20)23/h2-11,16,21H,12-15,17H2,1H3,(H,25,27)
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77n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203374
PNG
(CHEMBL234825 | naphthalene-2-carboxylic acid [1-(3...)
Show SMILES Cc1cccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H26N2O/c1-18-5-4-6-19(15-18)17-26-13-11-23(12-14-26)25-24(27)22-10-9-20-7-2-3-8-21(20)16-22/h2-10,15-16,23H,11-14,17H2,1H3,(H,25,27)
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87n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203467
PNG
(CHEMBL229023 | N-(1-(1-phenylethyl)piperidin-4-yl)...)
Show SMILES CC(N1CCC(CC1)NC(=O)c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-18(19-7-3-2-4-8-19)26-15-13-23(14-16-26)25-24(27)22-12-11-20-9-5-6-10-21(20)17-22/h2-12,17-18,23H,13-16H2,1H3,(H,25,27)
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110n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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162n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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162n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203468
PNG
((4-(benzylamino)piperidin-1-yl)(naphthalen-2-yl)me...)
Show SMILES O=C(N1CCC(CC1)NCc1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)25-14-12-22(13-15-25)24-17-18-6-2-1-3-7-18/h1-11,16,22,24H,12-15,17H2
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167n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203377
PNG
(CHEMBL234647 | naphthalene-2-carboxylic acid [1-(2...)
Show SMILES Cc1ccccc1CN1CCC(CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H26N2O/c1-18-6-2-3-9-22(18)17-26-14-12-23(13-15-26)25-24(27)21-11-10-19-7-4-5-8-20(19)16-21/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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175n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203478
PNG
(CHEMBL229076 | naphthalen-2-yl(4-(phenethylamino)p...)
Show SMILES O=C(N1CCC(CC1)NCCc1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H26N2O/c27-24(22-11-10-20-8-4-5-9-21(20)18-22)26-16-13-23(14-17-26)25-15-12-19-6-2-1-3-7-19/h1-11,18,23,25H,12-17H2
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210n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203466
PNG
(CHEMBL229025 | N-(1-(4-phenylbutyl)piperidin-4-yl)...)
Show SMILES O=C(NC1CCN(CCCCc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H30N2O/c29-26(24-14-13-22-11-4-5-12-23(22)20-24)27-25-15-18-28(19-16-25)17-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-14,20,25H,6-7,10,15-19H2,(H,27,29)
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213n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203479
PNG
(CHEMBL229077 | naphthalen-2-yl(4-(3-phenylpropylam...)
Show SMILES O=C(N1CCC(CC1)NCCCc1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H28N2O/c28-25(23-13-12-21-10-4-5-11-22(21)19-23)27-17-14-24(15-18-27)26-16-6-9-20-7-2-1-3-8-20/h1-5,7-8,10-13,19,24,26H,6,9,14-18H2
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222n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203376
PNG
(CHEMBL234826 | naphthalene-2-carboxylic acid [1-(4...)
Show SMILES Cc1ccc(CN2CCC(CC2)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H26N2O/c1-18-6-8-19(9-7-18)17-26-14-12-23(13-15-26)25-24(27)22-11-10-20-4-2-3-5-21(20)16-22/h2-11,16,23H,12-15,17H2,1H3,(H,25,27)
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222n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203474
PNG
(CHEMBL228865 | N-(1-(1-phenylethyl)piperidin-4-yl)...)
Show SMILES CC(N1CCC(CC1)NC(=O)c1cccc2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-18(19-8-3-2-4-9-19)26-16-14-21(15-17-26)25-24(27)23-13-7-11-20-10-5-6-12-22(20)23/h2-13,18,21H,14-17H2,1H3,(H,25,27)
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248n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50203466
PNG
(CHEMBL229025 | N-(1-(4-phenylbutyl)piperidin-4-yl)...)
Show SMILES O=C(NC1CCN(CCCCc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H30N2O/c29-26(24-14-13-22-11-4-5-12-23(22)20-24)27-25-15-18-28(19-16-25)17-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-14,20,25H,6-7,10,15-19H2,(H,27,29)
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281n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]nemonapride from human cloned dopamine D4.2 receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192179
PNG
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)
Show SMILES O=C(NC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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347n/an/an/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding activity against human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat 5HT2A receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université du Droit et de la Santé Lille II

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 17: 1570-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.106
BindingDB Entry DOI: 10.7270/Q2Z037T3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM50203375
PNG
(CHEMBL229019 | N-(1-benzylpiperidin-4-yl)-1-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O/c26-23(22-12-6-10-19-9-4-5-11-21(19)22)24-20-13-15-25(16-14-20)17-18-7-2-1-3-8-18/h1-12,20H,13-17H2,(H,24,26)
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>1.00E+3n/an/an/an/an/an/an/an/a



Faculté des Sciences Pharmaceutiques et Biologiques de Lille

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from rat cloned 5HT2A receptor


Bioorg Med Chem Lett 17: 1565-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.096
BindingDB Entry DOI: 10.7270/Q2T72H3S
More data for this
Ligand-Target Pair
Betaine transporter


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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1.50E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human BGT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 2


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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2.30E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT2 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 3


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
GABA transporter 1


(Homo sapiens (Human))
BDBM50203383
PNG
(CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphth...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N2O/c26-23(21-11-10-19-8-4-5-9-20(19)16-21)24-22-12-14-25(15-13-22)17-18-6-2-1-3-7-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting method


J Med Chem 60: 8834-8846 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00924
BindingDB Entry DOI: 10.7270/Q2M61NN1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50192179
PNG
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)
Show SMILES O=C(NC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26)
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n/an/a 948n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1


Bioorg Med Chem Lett 16: 5445-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50302312
PNG
(CHEMBL577272 | N-(piperidin-4-yl)-2-naphthamide)
Show SMILES O=C(NC1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H18N2O/c19-16(18-15-7-9-17-10-8-15)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11,15,17H,7-10H2,(H,18,19)
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n/an/a>400n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting


Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair