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6 similar compounds to monomer 100283

Compile data set for download or QSAR
Wt: 251.1
BDBM50280242
Purchase
Wt: 312.1
BDBM50281343
Wt: 253.1
BDBM50281988
Purchase
Wt: 309.1
BDBM50281993
Wt: 309.1
BDBM50283578
Wt: 238.1
BDBM50403589

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50280242,50281343,50281988,50281993,50283578,50403589   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50283578
PNG
((3R,4R,5R)-5-Carboxymethoxy-4-hydroxy-3-phosphonoo...)
Show SMILES O[C@@H]1[C@@H](CC(=C[C@H]1OP(O)([O-])=O)C([O-])=O)OCC([O-])=O
Show InChI InChI=1S/C9H13O10P/c10-7(11)3-18-5-1-4(9(13)14)2-6(8(5)12)19-20(15,16)17/h2,5-6,8,12H,1,3H2,(H,10,11)(H,13,14)(H2,15,16,17)/p-3/t5-,6-,8-/m1/s1
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Article
1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli EPSP synthase


Bioorg Med Chem Lett 4: 2605-2608 (1994)


Article DOI: 10.1016/S0960-894X(01)80293-6
BindingDB Entry DOI: 10.7270/Q25M666T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50281993
PNG
(CHEMBL287334 | Trisodium salt of (3R,4S,5R)-5-Carb...)
Show SMILES O[C@H]1[C@@H](CC(=C[C@H]1OP(O)([O-])=O)C([O-])=O)OCC([O-])=O
Show InChI InChI=1S/C9H13O10P/c10-7(11)3-18-5-1-4(9(13)14)2-6(8(5)12)19-20(15,16)17/h2,5-6,8,12H,1,3H2,(H,10,11)(H,13,14)(H2,15,16,17)/p-3/t5-,6-,8+/m1/s1
PDB
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KEGG

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Article
1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dissociation constant of the compound was calculated for E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase


Bioorg Med Chem Lett 3: 1435-1440 (1993)


Article DOI: 10.1016/S0960-894X(01)80425-X
BindingDB Entry DOI: 10.7270/Q2SN08W8
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50281343
PNG
((3R,4S,5R)-5-Carboxymethoxy-4-hydroxy-3-phosphonoo...)
Show SMILES O[C@H]1[C@@H](CC(=C[C@H]1OP(O)(O)=O)C(O)=O)OCC(O)=O
Show InChI InChI=1S/C9H13O10P/c10-7(11)3-18-5-1-4(9(13)14)2-6(8(5)12)19-20(15,16)17/h2,5-6,8,12H,1,3H2,(H,10,11)(H,13,14)(H2,15,16,17)/t5-,6-,8+/m1/s1
PDB
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KEGG

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PC cid
PC sid
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Article
1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSP).


Bioorg Med Chem Lett 3: 2857-2862 (1993)


Article DOI: 10.1016/S0960-894X(01)80779-4
BindingDB Entry DOI: 10.7270/Q2SX6D43
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50403589
PNG
(CHEMBL1160690)
Show SMILES O[C@H]1CCC(=C[C@H]1OP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C7H11O7P/c8-5-2-1-4(7(9)10)3-6(5)14-15(11,12)13/h3,5-6,8H,1-2H2,(H,9,10)(H2,11,12,13)/t5-,6+/m0/s1
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Article
1.30E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.


Bioorg Med Chem Lett 6: 2853-2858 (1996)


Article DOI: 10.1016/S0960-894X(96)00527-6
BindingDB Entry DOI: 10.7270/Q2833SJZ
More data for this
Ligand-Target Pair
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50280242
PNG
((3R,4S,5R)-4,5-Dihydroxy-3-phosphonooxy-cyclohex-1...)
Show SMILES O[C@@H]1CC(=C[C@@H](OP([O-])([O-])=O)[C@H]1O)C([O-])=O
Show InChI InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/p-3/t4-,5-,6+/m1/s1
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CHEBI
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PDB
UniChem

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PDB
Article
n/an/an/a 7.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli EPSP synthase


Bioorg Med Chem Lett 4: 2605-2608 (1994)


Article DOI: 10.1016/S0960-894X(01)80293-6
BindingDB Entry DOI: 10.7270/Q25M666T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50283578
PNG
((3R,4R,5R)-5-Carboxymethoxy-4-hydroxy-3-phosphonoo...)
Show SMILES O[C@@H]1[C@@H](CC(=C[C@H]1OP(O)([O-])=O)C([O-])=O)OCC([O-])=O
Show InChI InChI=1S/C9H13O10P/c10-7(11)3-18-5-1-4(9(13)14)2-6(8(5)12)19-20(15,16)17/h2,5-6,8,12H,1,3H2,(H,10,11)(H,13,14)(H2,15,16,17)/p-3/t5-,6-,8-/m1/s1
PDB
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KEGG

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PC cid
PC sid
UniChem

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Article
n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli EPSP synthase


Bioorg Med Chem Lett 4: 2605-2608 (1994)


Article DOI: 10.1016/S0960-894X(01)80293-6
BindingDB Entry DOI: 10.7270/Q25M666T
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50280242
PNG
((3R,4S,5R)-4,5-Dihydroxy-3-phosphonooxy-cyclohex-1...)
Show SMILES O[C@@H]1CC(=C[C@@H](OP([O-])([O-])=O)[C@H]1O)C([O-])=O
Show InChI InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/p-3/t4-,5-,6+/m1/s1
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CHEBI
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Article
n/an/an/a 7.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.


Bioorg Med Chem Lett 6: 2853-2858 (1996)


Article DOI: 10.1016/S0960-894X(96)00527-6
BindingDB Entry DOI: 10.7270/Q2833SJZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50280242
PNG
((3R,4S,5R)-4,5-Dihydroxy-3-phosphonooxy-cyclohex-1...)
Show SMILES O[C@@H]1CC(=C[C@@H](OP([O-])([O-])=O)[C@H]1O)C([O-])=O
Show InChI InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/p-3/t4-,5-,6+/m1/s1
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CHEBI
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Article
n/an/an/a 7.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of E. coli 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSP).


Bioorg Med Chem Lett 3: 2857-2862 (1993)


Article DOI: 10.1016/S0960-894X(01)80779-4
BindingDB Entry DOI: 10.7270/Q2SX6D43
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50281993
PNG
(CHEMBL287334 | Trisodium salt of (3R,4S,5R)-5-Carb...)
Show SMILES O[C@H]1[C@@H](CC(=C[C@H]1OP(O)([O-])=O)C([O-])=O)OCC([O-])=O
Show InChI InChI=1S/C9H13O10P/c10-7(11)3-18-5-1-4(9(13)14)2-6(8(5)12)19-20(15,16)17/h2,5-6,8,12H,1,3H2,(H,10,11)(H,13,14)(H2,15,16,17)/p-3/t5-,6-,8+/m1/s1
PDB
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KEGG

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PC cid
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Article
n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase


Bioorg Med Chem Lett 3: 1435-1440 (1993)


Article DOI: 10.1016/S0960-894X(01)80425-X
BindingDB Entry DOI: 10.7270/Q2SN08W8
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50281988
PNG
(CHEMBL32352 | Sodium salt of (3R,4S,5R)-4,5-Dihydr...)
Show SMILES O[C@@H]1CC(=C[C@@H](OP(O)([O-])=O)[C@H]1O)C(O)=O
Show InChI InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/p-1/t4-,5-,6+/m1/s1
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CHEBI
CHEMBL
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PC cid
PC sid
UniChem

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Article
n/an/an/a 7.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase


Bioorg Med Chem Lett 3: 1435-1440 (1993)


Article DOI: 10.1016/S0960-894X(01)80425-X
BindingDB Entry DOI: 10.7270/Q2SN08W8
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-enolpyruvylshikimate-3-phosphate synthase


(Escherichia coli (strain K12))
BDBM50280242
PNG
((3R,4S,5R)-4,5-Dihydroxy-3-phosphonooxy-cyclohex-1...)
Show SMILES O[C@@H]1CC(=C[C@@H](OP([O-])([O-])=O)[C@H]1O)C([O-])=O
Show InChI InChI=1S/C7H11O8P/c8-4-1-3(7(10)11)2-5(6(4)9)15-16(12,13)14/h2,4-6,8-9H,1H2,(H,10,11)(H2,12,13,14)/p-3/t4-,5-,6+/m1/s1
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CHEBI
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Article
n/an/an/a 8.00E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dissociation constant of the at EPSP synthase was determined


Bioorg Med Chem Lett 2: 1435-1440 (1992)


Article DOI: 10.1016/S0960-894X(00)80527-2
BindingDB Entry DOI: 10.7270/Q2XD1244
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)