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18 similar compounds to monomer 50316349

Compile data set for download or QSAR
Wt: 391.4
BDBM50316342
Wt: 405.4
BDBM50316343
Wt: 405.4
BDBM50316344
Wt: 419.4
BDBM50316345
Wt: 419.4
BDBM50316346
Wt: 447.5
BDBM50316347
Wt: 447.5
BDBM50316348
Wt: 481.5
BDBM50316350
Wt: 499.5
BDBM50316351
Wt: 499.5
BDBM50316352
Wt: 549.5
BDBM50316353
Wt: 549.5
BDBM50316354
Wt: 520.5
BDBM50316355
Wt: 520.5
BDBM50316356
Wt: 515.9
BDBM50316357
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50316342,50316343,50316344,50316345,50316346,50316347,50316348,50316350,50316351,50316352,50316353,50316354,50316355,50316356,50316357   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316342
PNG
(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OCCN)c1
Show InChI InChI=1S/C21H21N5O3/c1-27-19-7-15-14-6-17(12-5-13(10-24-9-12)29-4-3-22)26-21(23)16(14)11-25-18(15)8-20(19)28-2/h5-11H,3-4,22H2,1-2H3,(H2,23,26)
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n/an/a 5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316357
PNG
(2-(5-{[(2S)-2-Amino-3-(2-chlorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C28H26ClN5O3/c1-35-26-10-21-20-9-24(34-28(31)22(20)14-33-25(21)11-27(26)36-2)17-8-19(13-32-12-17)37-15-18(30)7-16-5-3-4-6-23(16)29/h3-6,8-14,18H,7,15,30H2,1-2H3,(H2,31,34)/t18-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316344
PNG
(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316345
PNG
(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316346
PNG
(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316347
PNG
(2-(5-{[(2S)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316348
PNG
(2-(5-{[(2R)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316350
PNG
(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccccc2)c1
Show InChI InChI=1S/C28H27N5O3/c1-34-26-11-22-21-10-24(33-28(30)23(21)15-32-25(22)12-27(26)35-2)18-9-20(14-31-13-18)36-16-19(29)8-17-6-4-3-5-7-17/h3-7,9-15,19H,8,16,29H2,1-2H3,(H2,30,33)/t19-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316351
PNG
(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316352
PNG
(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316353
PNG
(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316354
PNG
(2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316355
PNG
(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316356
PNG
(2-(5-{[(2R)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316357
PNG
(2-(5-{[(2S)-2-Amino-3-(2-chlorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C28H26ClN5O3/c1-35-26-10-21-20-9-24(34-28(31)22(20)14-33-25(21)11-27(26)36-2)17-8-19(13-32-12-17)37-15-18(30)7-16-5-3-4-6-23(16)29/h3-6,8-14,18H,7,15,30H2,1-2H3,(H2,31,34)/t18-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316342
PNG
(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OCCN)c1
Show InChI InChI=1S/C21H21N5O3/c1-27-19-7-15-14-6-17(12-5-13(10-24-9-12)29-4-3-22)26-21(23)16(14)11-25-18(15)8-20(19)28-2/h5-11H,3-4,22H2,1-2H3,(H2,23,26)
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n/an/a 402n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316343
PNG
(2-(5-{[(2S)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m0/s1
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n/an/a 712n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316344
PNG
(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m1/s1
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n/an/a 377n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316345
PNG
(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m0/s1
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n/an/a 422n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316346
PNG
(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m1/s1
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n/an/a 318n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316347
PNG
(2-(5-{[(2S)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m0/s1
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n/an/a 905n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316348
PNG
(2-(5-{[(2R)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316350
PNG
(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccccc2)c1
Show InChI InChI=1S/C28H27N5O3/c1-34-26-11-22-21-10-24(33-28(30)23(21)15-32-25(22)12-27(26)35-2)18-9-20(14-31-13-18)36-16-19(29)8-17-6-4-3-5-7-17/h3-7,9-15,19H,8,16,29H2,1-2H3,(H2,30,33)/t19-/m1/s1
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n/an/a 259n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316351
PNG
(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m0/s1
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n/an/a 183n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316352
PNG
(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m1/s1
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n/an/a 251n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316353
PNG
(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m0/s1
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n/an/a 209n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316354
PNG
(2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1
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n/an/a 889n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316355
PNG
(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m0/s1
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n/an/a 302n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316356
PNG
(2-(5-{[(2R)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m1/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316357
PNG
(2-(5-{[(2S)-2-Amino-3-(2-chlorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C28H26ClN5O3/c1-35-26-10-21-20-9-24(34-28(31)22(20)14-33-25(21)11-27(26)36-2)17-8-19(13-32-12-17)37-15-18(30)7-16-5-3-4-6-23(16)29/h3-6,8-14,18H,7,15,30H2,1-2H3,(H2,31,34)/t18-/m0/s1
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n/an/a 793n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of AKT


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316342
PNG
(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OCCN)c1
Show InChI InChI=1S/C21H21N5O3/c1-27-19-7-15-14-6-17(12-5-13(10-24-9-12)29-4-3-22)26-21(23)16(14)11-25-18(15)8-20(19)28-2/h5-11H,3-4,22H2,1-2H3,(H2,23,26)
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n/an/a 80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316343
PNG
(2-(5-{[(2S)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m0/s1
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n/an/a 235n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316344
PNG
(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m1/s1
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n/an/a 97n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316345
PNG
(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m0/s1
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n/an/a 216n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316346
PNG
(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Show SMILES CC[C@@H](N)COc1cncc(c1)-c1cc2c(cnc3cc(OC)c(OC)cc23)c(N)n1
Show InChI InChI=1S/C23H25N5O3/c1-4-14(24)12-31-15-5-13(9-26-10-15)19-6-16-17-7-21(29-2)22(30-3)8-20(17)27-11-18(16)23(25)28-19/h5-11,14H,4,12,24H2,1-3H3,(H2,25,28)/t14-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316347
PNG
(2-(5-{[(2S)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m0/s1
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n/an/a 219n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316348
PNG
(2-(5-{[(2R)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)CC(C)C)c1
Show InChI InChI=1S/C25H29N5O3/c1-14(2)5-16(26)13-33-17-6-15(10-28-11-17)21-7-18-19-8-23(31-3)24(32-4)9-22(19)29-12-20(18)25(27)30-21/h6-12,14,16H,5,13,26H2,1-4H3,(H2,27,30)/t16-/m1/s1
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n/an/a 443n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316350
PNG
(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccccc2)c1
Show InChI InChI=1S/C28H27N5O3/c1-34-26-11-22-21-10-24(33-28(30)23(21)15-32-25(22)12-27(26)35-2)18-9-20(14-31-13-18)36-16-19(29)8-17-6-4-3-5-7-17/h3-7,9-15,19H,8,16,29H2,1-2H3,(H2,30,33)/t19-/m1/s1
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n/an/a 88n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316351
PNG
(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316352
PNG
(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H26FN5O3/c1-35-26-10-22-21-9-24(34-28(31)23(21)14-33-25(22)11-27(26)36-2)17-8-20(13-32-12-17)37-15-19(30)7-16-3-5-18(29)6-4-16/h3-6,8-14,19H,7,15,30H2,1-2H3,(H2,31,34)/t19-/m1/s1
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n/an/a 93n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316353
PNG
(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m0/s1
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n/an/a 182n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316354
PNG
(2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O3/c1-38-26-10-22-21-9-24(37-28(34)23(21)14-36-25(22)11-27(26)39-2)17-8-20(13-35-12-17)40-15-19(33)7-16-4-3-5-18(6-16)29(30,31)32/h3-6,8-14,19H,7,15,33H2,1-2H3,(H2,34,37)/t19-/m1/s1
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n/an/a 763n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316355
PNG
(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50316356
PNG
(2-(5-{[(2R)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C30H28N6O3/c1-37-28-10-23-22-9-26(36-30(32)24(22)15-35-27(23)11-29(28)38-2)18-8-20(14-33-12-18)39-16-19(31)7-17-13-34-25-6-4-3-5-21(17)25/h3-6,8-15,19,34H,7,16,31H2,1-2H3,(H2,32,36)/t19-/m1/s1
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n/an/a 254n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50316343
PNG
(2-(5-{[(2S)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@H](C)N)c1
Show InChI InChI=1S/C22H23N5O3/c1-12(23)11-30-14-4-13(8-25-9-14)18-5-15-16-6-20(28-2)21(29-3)7-19(16)26-10-17(15)22(24)27-18/h4-10,12H,11,23H2,1-3H3,(H2,24,27)/t12-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells


Eur J Med Chem 45: 1379-86 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5
More data for this
Ligand-Target Pair