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14 similar compounds to monomer 65837

Compile data set for download or QSAR
Wt: 342.3
BDBM150749
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Wt: 400.4
BDBM57538
Wt: 326.3
BDBM67490
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Wt: 386.4
BDBM67491
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Wt: 416.4
BDBM67493
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Wt: 372.4
BDBM67506
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Wt: 342.3
BDBM67460
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Wt: 326.3
BDBM67462
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Wt: 312.3
BDBM67466
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Wt: 356.4
BDBM67472
Wt: 372.4
BDBM67487
Wt: 464.5
BDBM50113297
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Wt: 451.3
BDBM50343412
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Wt: 400.4
BDBM50396412
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 150749,57538,67490,67491,67493,67506,67460,67462,67466,67472,67487,50113297,50343412,50396412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM57538
PNG
(2-(1,3-benzodioxol-5-yl)-4,5-bis(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H20N2O4/c1-27-18-8-3-15(4-9-18)22-23(16-5-10-19(28-2)11-6-16)26-24(25-22)17-7-12-20-21(13-17)30-14-29-20/h3-13H,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 2.07E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2736PBV
More data for this
Ligand-Target Pair
Sphingomyelin phosphodiesterase 3


(Homo sapiens)
BDBM67506
PNG
(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2,6...)
Show SMILES COc1cc(cc(OC)c1O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-27-18-13-17(14-19(28-2)22(18)26)23-24-20(15-9-5-3-6-10-15)21(25-23)16-11-7-4-8-12-16/h3-14,26H,1-2H3,(H,24,25)
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n/an/a 20n/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...


Eur J Med Chem 170: 276-289 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.015
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67462
PNG
(2-(3-methoxyphenyl)-4,5-diphenyl-1H-imidazole | SR...)
Show SMILES COc1cccc(c1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O/c1-25-19-14-8-13-18(15-19)22-23-20(16-9-4-2-5-10-16)21(24-22)17-11-6-3-7-12-17/h2-15H,1H3,(H,23,24)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67466
PNG
(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-1-c...)
Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O/c24-18-13-11-17(12-14-18)21-22-19(15-7-3-1-4-8-15)20(23-21)16-9-5-2-6-10-16/h1-14,24H,(H,22,23)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67472
PNG
(2-(3,4-dimethoxyphenyl)-4,5-diphenyl-1H-imidazole ...)
Show SMILES COc1ccc(cc1OC)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-26-19-14-13-18(15-20(19)27-2)23-24-21(16-9-5-3-6-10-16)22(25-23)17-11-7-4-8-12-17/h3-15H,1-2H3,(H,24,25)
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n/an/a>1.70E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67487
PNG
(4-[4,5-bis(4-methoxyphenyl)-1,3-dihydroimidazol-2-...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C23H20N2O3/c1-27-19-11-5-15(6-12-19)21-22(16-7-13-20(28-2)14-8-16)25-23(24-21)17-3-9-18(26)10-4-17/h3-14,26H,1-2H3,(H,24,25)
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n/an/a 9.01E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67490
PNG
(2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole | SR...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O/c1-25-19-14-12-18(13-15-19)22-23-20(16-8-4-2-5-9-16)21(24-22)17-10-6-3-7-11-17/h2-15H,1H3,(H,23,24)
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n/an/a>1.70E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67491
PNG
(2,4,5-tris(4-methoxyphenyl)-1H-imidazole | SR-0300...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C24H22N2O3/c1-27-19-10-4-16(5-11-19)22-23(17-6-12-20(28-2)13-7-17)26-24(25-22)18-8-14-21(29-3)15-9-18/h4-15H,1-3H3,(H,25,26)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67493
PNG
(2-(3,4-dimethoxyphenyl)-4,5-bis(4-methoxyphenyl)-1...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C25H24N2O4/c1-28-19-10-5-16(6-11-19)23-24(17-7-12-20(29-2)13-8-17)27-25(26-23)18-9-14-21(30-3)22(15-18)31-4/h5-15H,1-4H3,(H,26,27)
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n/an/a>1.70E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67506
PNG
(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2,6...)
Show SMILES COc1cc(cc(OC)c1O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-27-18-13-17(14-19(28-2)22(18)26)23-24-20(15-9-5-3-6-10-15)21(25-23)16-11-7-4-8-12-16/h3-14,26H,1-2H3,(H,24,25)
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n/an/a 517n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67506
PNG
(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2,6...)
Show SMILES COc1cc(cc(OC)c1O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3/c1-27-18-13-17(14-19(28-2)22(18)26)23-24-20(15-9-5-3-6-10-15)21(25-23)16-11-7-4-8-12-16/h3-14,26H,1-2H3,(H,24,25)
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n/an/a 900n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2JD4V7Q
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM67462
PNG
(2-(3-methoxyphenyl)-4,5-diphenyl-1H-imidazole | SR...)
Show SMILES COc1cccc(c1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O/c1-25-19-14-8-13-18(15-19)22-23-20(16-9-4-2-5-10-16)21(24-22)17-11-6-3-7-12-17/h2-15H,1H3,(H,23,24)
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n/an/a 3.59E+5n/an/an/an/an/a37



COMSATS Institute of Information Technology



Assay Description
A 100 無 assay mixture containing 70 無 phosphate buffer saline (50 mM at pH 6.8), 10 無 corresponding test compounds dissolved in methanol/DMSO (0.5...


Bioorg Chem 58: 65-71 (2015)


Article DOI: 10.1016/j.bioorg.2014.11.006
BindingDB Entry DOI: 10.7270/Q22N5103
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM67466
PNG
(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-1-c...)
Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O/c24-18-13-11-17(12-14-18)21-22-19(15-7-3-1-4-8-15)20(23-21)16-9-5-2-6-10-16/h1-14,24H,(H,22,23)
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n/an/a 9.71E+4n/an/an/an/an/a37



COMSATS Institute of Information Technology



Assay Description
A 100 無 assay mixture containing 70 無 phosphate buffer saline (50 mM at pH 6.8), 10 無 corresponding test compounds dissolved in methanol/DMSO (0.5...


Bioorg Chem 58: 65-71 (2015)


Article DOI: 10.1016/j.bioorg.2014.11.006
BindingDB Entry DOI: 10.7270/Q22N5103
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150749
PNG
(2-(4,5-Diphenyl-1H-imidazol-2-yl)-6-methoxyphenol ...)
Show SMILES COc1cccc(-c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)c1O
Show InChI InChI=1S/C22H18N2O2/c1-26-18-14-8-13-17(21(18)25)22-23-19(15-9-4-2-5-10-15)20(24-22)16-11-6-3-7-12-16/h2-14,25H,1H3,(H,23,24)
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n/an/a 1.07E+5n/an/an/an/an/a37



COMSATS Institute of Information Technology



Assay Description
A 100 無 assay mixture containing 70 無 phosphate buffer saline (50 mM at pH 6.8), 10 無 corresponding test compounds dissolved in methanol/DMSO (0.5...


Bioorg Chem 58: 65-71 (2015)


Article DOI: 10.1016/j.bioorg.2014.11.006
BindingDB Entry DOI: 10.7270/Q22N5103
More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM50343412
PNG
(4-[5-(4-bromophenyl)-4-phenyl-1H-imidazol-2-yl]-2,...)
Show SMILES COc1cc(cc(OC)c1O)-c1nc(c([nH]1)-c1ccc(Br)cc1)-c1ccccc1
Show InChI InChI=1S/C23H19BrN2O3/c1-28-18-12-16(13-19(29-2)22(18)27)23-25-20(14-6-4-3-5-7-14)21(26-23)15-8-10-17(24)11-9-15/h3-13,27H,1-2H3,(H,25,26)
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n/an/a 9.12E+4n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...


J Med Chem 54: 3260-7 (2011)


Article DOI: 10.1021/jm101554k
BindingDB Entry DOI: 10.7270/Q2J103GF
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (Human))
BDBM50113297
PNG
(3-(4,5-Bis-biphenyl-4-yl-1H-imidazol-2-yl)-phenol ...)
Show SMILES Oc1cccc(c1)-c1nc(c([nH]1)-c1ccc(cc1)-c1ccccc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C33H24N2O/c36-30-13-7-12-29(22-30)33-34-31(27-18-14-25(15-19-27)23-8-3-1-4-9-23)32(35-33)28-20-16-26(17-21-28)24-10-5-2-6-11-24/h1-22,36H,(H,34,35)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human Protein-tyrosine phosphatase 1B (PTP1B) dephosphorylation of insulin receptor peptide


J Med Chem 45: 2213-21 (2002)


Article DOI: 10.1021/jm010548w
BindingDB Entry DOI: 10.7270/Q2SB46F1
More data for this
Ligand-Target Pair
Myeloperoxidase (MPO)


(Homo sapiens (Human))
BDBM50396412
PNG
(CHEMBL2170246)
Show SMILES COc1cc(ccc1OCC(O)=O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H20N2O4/c1-29-20-14-18(12-13-19(20)30-15-21(27)28)24-25-22(16-8-4-2-5-9-16)23(26-24)17-10-6-3-7-11-17/h2-14H,15H2,1H3,(H,25,26)(H,27,28)
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n/an/a 970n/an/an/an/an/an/a



Universit£ Libre de Bruxelles

Curated by ChEMBL


Assay Description
Inhibition of recombinant human myeloperoxidase assessed as taurine chloramine production after 5 mins by spectrophotometry in presence of H2O2


J Med Chem 55: 7208-18 (2012)


Article DOI: 10.1021/jm3007245
BindingDB Entry DOI: 10.7270/Q2PR7X41
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))
BDBM67460
PNG
(5-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxy-phenol...)
Show SMILES COc1ccc(cc1O)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O2/c1-26-19-13-12-17(14-18(19)25)22-23-20(15-8-4-2-5-9-15)21(24-22)16-10-6-3-7-11-16/h2-14,25H,1H3,(H,23,24)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2KK998G
More data for this
Ligand-Target Pair