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Found 191 Enz. Inhib. hit(s) with Target = 'Eukaryotic elongation factor 2 kinase'
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50442757(CHEMBL2443026)
Affinity DataIC50: >10nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50442758(CHEMBL2443139)
Affinity DataIC50: >10nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50442759(CHEMBL2443138)
Affinity DataIC50: >10nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50442760(CHEMBL2443044)
Affinity DataIC50: >10nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50600470(CHEMBL5174034)
Affinity DataIC50:  32nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50284911(CHEMBL4171806)
Affinity DataIC50:  60nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human eEF2K expressed in Escherichia coli using biotinylated myelin basic protein as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50555899(CHEMBL1683636)
Affinity DataIC50:  60nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50600471(CHEMBL5204448)
Affinity DataIC50:  69nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314444(2-(4-chlorophenyl)-10-thia-5,7,12-triazatetracyclo...)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314436(3-amino-4-(furan-2-yl)-6,7,8,9,10,11-hexahydro-5H-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314406(8-(morpholin-4-yl)-11-thia-9,14,16-triazatetracycl...)
Affinity DataIC50:  220nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314406(8-(morpholin-4-yl)-11-thia-9,14,16-triazatetracycl...)
Affinity DataIC50:  220nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50600472(CHEMBL5194579)
Affinity DataIC50:  230nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50:  280nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50:  280nMAssay Description:ATP competitive inhibition of human eEF-2K using 5 uM ATPMore data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314427(3-amino-4-(5-chlorofuran-2-yl)-5,6,7,8,9,10-hexahy...)
Affinity DataIC50:  280nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293963(US10106552, Compound 38)
Affinity DataIC50:  300nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314428(3-amino-4-(5-(trifluoromethyl)furan-2-yl)-5,6,7,8,...)
Affinity DataIC50:  300nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50555900(CHEMBL4776943)
Affinity DataIC50:  310nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314419((E)-3-amino-4-(2-(furan-2-yl)vinyl)-5,6,7,8,9,10-h...)
Affinity DataIC50:  320nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314429(3-amino-4-(benzofuran-2-yl)-5,6,7,8,9,10-hexahydro...)
Affinity DataIC50:  330nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314442(2-(furan-2-yl)-10-thia-5,7,12-triazatetracyclo[11....)
Affinity DataIC50:  350nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Rattus norvegicus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50284575(CHEMBL4173539)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant rat GST-tagged eEF2K expressed in Escherichia coli BL21 (DE3) cells using yeast eEF2 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293965(US10106552, Compound 40)
Affinity DataIC50:  400nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293961(US10106552, Compound 36)
Affinity DataIC50:  400nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293960(US10106552, Compound 35)
Affinity DataIC50:  400nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293953(US10106552, Compound 28)
Affinity DataIC50:  400nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50:  420nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50:  420nMAssay Description:Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...More data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50375667(CHEMBL437612 | TX-1918)
Affinity DataIC50:  440nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50375667(CHEMBL437612 | TX-1918)
Affinity DataIC50:  440nMAssay Description:Inhibition of eEF2 kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50375667(CHEMBL437612 | TX-1918)
Affinity DataIC50:  440nMAssay Description:Inhibition of eEF2K in human A431 cells using eEF2 as substrate preincubated for 30 mins followed by ATP/[gamma-32P]-ATP addition measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314420(3-amino-4-(3-methylthiophen-2-yl)-5,6,7,8,9,10-hex...)
Affinity DataIC50:  460nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293966(US10106552, Compound 41)
Affinity DataIC50:  500nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053584(CHEMBL1977874)
Affinity DataIC50:  510nMAssay Description:Inhibition of eEF2K (unknown origin) using peptide MH-1 as substrate after 2 hrs by ADP-Glo luminescent assayMore data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314418(3-amino-4-(furan-2-yl)-5,6,7,8,9,10-hexahydrocyclo...)
Affinity DataIC50:  640nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314430(3-amino-4-(5-ethylfuran-2-yl)-5,6,7,8,9,10-hexahyd...)
Affinity DataIC50:  660nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293954(US10106552, Compound 29)
Affinity DataIC50:  700nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50464814(CHEMBL4281348)
Affinity DataIC50:  760nMAssay Description:Inhibition of eEF2K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50464814(CHEMBL4281348)
Affinity DataIC50:  762nMAssay Description:Inhibition of GST-tagged EEF2K (unknown origin) using biotinylated EEF2 peptide substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293950(US10106552, Compound 25)
Affinity DataIC50:  800nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293959(US10106552, Compound 34)
Affinity DataIC50:  800nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314431(3-amino-4-(5-(hydroxymethyl)furan-2-yl)-5,6,7,8,9,...)
Affinity DataIC50:  800nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314415(4-(3-amino-2-carbamoyl-5,6,7,8,9,10-hexahydrocyclo...)
Affinity DataIC50:  860nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314409(3-amino-4-isobutyl-5,6,7,8,9,10-hexahydrocycloocta...)
Affinity DataIC50:  860nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293968(US10106552, Compound 43)
Affinity DataIC50:  900nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293962(US10106552, Compound 37)
Affinity DataIC50:  900nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM293943(US10106552, Compound 18)
Affinity DataIC50:  900nMAssay Description:To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50053583(CHEMBL3327225)
Affinity DataIC50:  930nMAssay Description:Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50314421(3-amino-4-(pyridin-3-yl)-5,6,7,8,9,10-hexahydrocyc...)
Affinity DataIC50:  940nMAssay Description:Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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