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Found 376 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit beta'
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214664(5-chloromethyl-1-(2,6-dichloro-4-trifluoromethylph...)
Affinity DataKi:  0.659nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214659(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methyl-...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214673(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-hydroxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214650(1-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dieth...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214662(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethyl-5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214670(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethyl-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214665(1-(2,6-dibromo-4-trifluoromethylphenyl)-5-methyl-4...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214653(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethyl-5...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214661(4-chloromethyl-1-(2,6-dichloro-4-trifluoromethylph...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214647(1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5-ethyl...)
Affinity DataKi:  70.1nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214648(1-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-di-np...)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214666(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-methyl-...)
Affinity DataKi:  539nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214651(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-hydroxy...)
Affinity DataKi:  3.45E+3nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106148(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106149(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106148(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106149(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179909(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-methy...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179898(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4,4,6,6...)
Affinity DataIC50:  74nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179896(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-2,4,5,6...)
Affinity DataIC50:  83nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179908(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5-fluor...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179903(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5,5-dif...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta(Musca domestica)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50179912(2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4,4-dif...)
Affinity DataIC50: >100nMAssay Description:Displacement of [3H]EBOB from housefly neuronal membrane GABA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625617(US20230322846, Example 3)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625619(US20230322846, Example 5)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625622(US20230322846, Example 8)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625626(US20230322846, Example 12)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625627(Synthesis of (R)-1-(((3R,5R,8R,9R,10S,13S,14S,17S)...)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625629(US20230322846, Example 15)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625630(US20230322846, Example 16)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625632(US20230322846, Example 18)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625636(US20230322846, Example 22)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625638(US20230322846, Example 24)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625639(Synthesis of (3R,5R,8R,9R,10S,13S,14S,17S)-3,13-di...)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625645(US20230322846, Example 33)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625646(US20230322846, Example 34)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625647(US20230322846, Example 35)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625648(US20230322846, Example 36)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625649(US20230322846, Example 37)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625652(US20230322846, Example 40)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625656(US20230322846, Example 44)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625657(US20230322846, Example 45)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625658(US20230322846, Example 46)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625659(Synthesis of (3R,5R,8R,9R,10S,13R,14S,17R)-3-(meth...)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625660(US20230322846, Example 48)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625661(Synthesis of (3R,5R,8R,9R,10S,13R,14S,17R)-17-(2-(...)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625662(US20230322846, Example 50)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625663(Synthesis of 1-((R)-2-((3R,5R,8R,9R,10S,13S,14S,17...)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625664(US20230322846, Example 52)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit beta-1(Rat)
Sage Therapeutics

US Patent
LigandPNGBDBM625667(US20230322846, Example 55)
Affinity DataIC50: <100nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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