Compile Data Set for Download or QSAR
maximum 50k data
Found 187 Enz. Inhib. hit(s) with Target = 'Intermediate conductance calcium-activated potassium channel protein 4'
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371391(SENICAPOC)
Affinity DataIC50:  6nMAssay Description:Inhibition of Kca 3.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50547905(CHEMBL4744833)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50547897(CHEMBL4749039)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50547904(CHEMBL4791725)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Affinity DataIC50:  9nMAssay Description:Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371390(CHEMBL272039)
Affinity DataIC50:  10nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371391(SENICAPOC)
Affinity DataIC50:  12nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371385(CHEMBL260736)
Affinity DataIC50:  13nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371388(CHEMBL270704)
Affinity DataIC50:  14nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371389(CHEMBL272040)
Affinity DataIC50:  14nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50547898(CHEMBL4788143)
Affinity DataIC50:  14nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM314285(US9611232, Example 17)
Affinity DataIC50:  15nMAssay Description:Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM314248(US9611232, Example 13)
Affinity DataIC50:  15nMAssay Description:Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50371384(CHEMBL270071)
Affinity DataIC50:  15nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371395(CHEMBL273092)
Affinity DataIC50:  15nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371382(CHEMBL408700)
Affinity DataIC50:  15nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM205030(US9556132, 7 | process for preparing 2-(2-{2-[1-(2...)
Affinity DataIC50:  16nMpH: 7.3Assay Description:Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM205069(US9556132, 33 | process for preparing 5-{2-[2-(flu...)
Affinity DataIC50:  17nMpH: 7.3Assay Description:Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50371386(CHEMBL260953)
Affinity DataIC50:  17nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50547900(CHEMBL4756080)
Affinity DataIC50:  18nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50279107(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371377(CHEMBL406683)
Affinity DataIC50:  20nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50279107(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM314217(US9611232, Example 11)
Affinity DataIC50:  22nMAssay Description:Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50547899(CHEMBL4764429)
Affinity DataIC50:  24nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM205019(US9556132, 4 | process for preparing 1-(2-fluoroph...)
Affinity DataIC50:  30nMpH: 7.3Assay Description:Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50371383(CHEMBL261828)
Affinity DataIC50:  30nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371387(CHEMBL261606)
Affinity DataIC50:  30nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371396(CHEMBL270913)
Affinity DataIC50:  34nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM205016(US9556132, 3 | process for preparing 5-[2-(2-ethox...)
Affinity DataIC50:  37nMpH: 7.3Assay Description:Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200905(US9533999, i-39)
Affinity DataIC50:  39nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50019902(CHEMBL3287207)
Affinity DataIC50:  39nMAssay Description:Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50371394(CHEMBL258604)
Affinity DataIC50:  40nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019905(CHEMBL3287210 | US9533999, ii-4)
Affinity DataIC50:  41nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50019905(CHEMBL3287210 | US9533999, ii-4)
Affinity DataIC50:  41nMAssay Description:Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM314284(US9611232, Example 15)
Affinity DataIC50:  42nMAssay Description:Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM314215(US9611232, Example 7)
Affinity DataIC50:  45nMAssay Description:Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200937(US9533999, ii-5)
Affinity DataIC50:  46nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50547901(CHEMBL4745327)
Affinity DataIC50:  47nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM200946(US9533999, ii-8)
Affinity DataIC50:  47nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50019903(CHEMBL3287208 | US9533999, i-40)
Affinity DataIC50:  48nMAssay Description:Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019903(CHEMBL3287208 | US9533999, i-40)
Affinity DataIC50:  48nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50019900(CHEMBL3287205 | US9533999, i-5)
Affinity DataIC50:  49nMAssay Description:Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019900(CHEMBL3287205 | US9533999, i-5)
Affinity DataIC50:  49nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50547906(CHEMBL4743839)
Affinity DataIC50:  52nMAssay Description:Inhibition of Kca3.1 in human erythrocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50019904(CHEMBL3287209 | US9533999, ii-1)
Affinity DataIC50:  52nMAssay Description:Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019904(CHEMBL3287209 | US9533999, ii-1)
Affinity DataIC50:  52nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM200942(US9533999, ii-7)
Affinity DataIC50:  52nMAssay Description:HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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