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Found 1681 Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-14'
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433865(CHEMBL2380402)
Affinity DataKi:  4nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433878(CHEMBL2380389)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433880(CHEMBL2380387)
Affinity DataKi:  6.20nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433864(CHEMBL2380403)
Affinity DataKi:  6.60nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433877(CHEMBL2380390)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50592895(CHEMBL5187653)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-14 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433871(CHEMBL2380396)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433868(CHEMBL2380400)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  14nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433866(CHEMBL2380314)
Affinity DataKi:  21nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078947((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-ca...)
Affinity DataKi:  22nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50423397(CHEMBL398271)
Affinity DataKi:  26nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078937((1-Benzyloxycarbonylamino-ethyl)-{3-benzylsulfanyl...)
Affinity DataKi:  26nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433872(CHEMBL2380395)
Affinity DataKi:  31nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433872(CHEMBL2380395)
Affinity DataKi:  31nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078935((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  32nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078951(CHEMBL87159 | [1-(2-Benzyloxy-acetylamino)-2-pheny...)
Affinity DataKi:  40nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078950((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  41nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078946(CHEMBL313360 | [1-(2-Benzyloxycarbonylamino-propio...)
Affinity DataKi:  41nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078945((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  45nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50104710((R)-N-(5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl...)
Affinity DataKi:  50nMAssay Description:Inhibition of matrix metalloproteinase-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078941(CHEMBL88188 | [1-(2-Benzyloxycarbonylamino-4-methy...)
Affinity DataKi:  53nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50459506(CHEMBL4214929)
Affinity DataKi:  53nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078932((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  60nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433867(CHEMBL2380401)
Affinity DataKi:  62nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078929((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  63nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  68nMAssay Description:Inhibition of recombinant human MMP14 catalytic domain (89 to 265 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433875(CHEMBL2380392)
Affinity DataKi:  68nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50433879(CHEMBL2380388)
Affinity DataKi:  70nMAssay Description:Inhibition of MMP-14 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078928((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  73nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50388914(CHEMBL2063274 | US10357546, p-OH SB-3CT)
Affinity DataKi:  90nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078943((1-Acetylamino-2-phenyl-ethyl)-{2-[1-carbamoyl-2-(...)
Affinity DataKi:  90nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50423403(CHEMBL251253)
Affinity DataKi:  91nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078954((1-Benzyloxycarbonylamino-ethyl)-{2-[1-carbamoyl-2...)
Affinity DataKi:  92nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  94nMAssay Description:Inhibition of matrix metalloprotease-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi: >100nM ΔG°: >-40.0kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50104721((S)-N-(5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl...)
Affinity DataKi:  100nMAssay Description:In vitro inhibitory activity against the catalytic domain of human matrix metalloprotease-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50138684((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  105nMAssay Description:Binding affinity to MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  105nMAssay Description:Inhibition of MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078930((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[(R)-...)
Affinity DataKi:  105nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50138684((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  105nMAssay Description:Inhibition of Matrix metalloprotease-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50104723(2-Benzenesulfonylamino-N-[5-(4-chloro-phenyl)-6H-[...)
Affinity DataKi:  110nMAssay Description:In vitro inhibitory activity against the ectodomain of the human matrix metalloproteinase-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  110nMAssay Description:Inhibition of MMP-14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14 [1-20,P8S](Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent
LigandPNGBDBM120258(US8691753, 95 bis)
Affinity DataKi:  118nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50459505(CHEMBL4215451)
Affinity DataKi:  119nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM389618(US10357546, ND-336 | US9951035, ND-336 (5))
Affinity DataKi:  120nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50343959(CHEMBL1779630 | rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)...)
Affinity DataKi:  120nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50078948((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  125nMAssay Description:Binding affinity against matrix metalloprotease-14 MTI-MMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1681 total ) | Next | Last >>
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