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Found 2479 Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 5'
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105879(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165931(CHEMBL415165 | NDP-SYSMEHFRWGKPVG)
Affinity DataKi:  0.170nMAssay Description:Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165935(Ac-YRMEHdFRWGSPPKD-NH2 | CHEMBL414718)
Affinity DataKi:  0.260nMAssay Description:Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105883(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389783(CHEMBL2070245)
Affinity DataKi:  0.470nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358564(CHEMBL1923667)
Affinity DataKi:  0.710nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358562(CHEMBL1923665)
Affinity DataKi:  0.760nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165932(Ac-YRMEHdFRWG-NH2 | CHEMBL266879)
Affinity DataKi:  0.840nMAssay Description:Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134946(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114088(9-Benzyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataKi: <1nMAssay Description:Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114083(9-Benzyl-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3...)
Affinity DataKi: <1nMAssay Description:Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114077(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)
Affinity DataKi: <1nMAssay Description:Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114085((O)C-(C6H4)-C(O)-c[His-D-Phe-Arg-Trp-Lys]-NH2) (MK...)
Affinity DataKi: <1nMAssay Description:Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389773(CHEMBL2070246)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358563(CHEMBL1923666)
Affinity DataKi:  1.40nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389771(CHEMBL2070243)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150842(4-[((R)-N-Cyclohexyl-3-methyl-piperazine-1-carboxi...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105882(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM85021(alpha-MSH, [Nle4, D-Phe7])
Affinity DataKi:  2.39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  2.39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389780(CHEMBL2069317)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389778(CHEMBL2070251)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389775(CHEMBL2070248)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389779(CHEMBL2070252)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358565(CHEMBL1923668)
Affinity DataKi:  3.90nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105880(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389772(CHEMBL2070244)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389770(CHEMBL2070242)
Affinity DataKi:  5.10nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150835(4-[N''-(2-Amino-2-methyl-propyl)-N''''-cyclohexyl-...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150837(4-[((S)-N-(R)-Cyclohexyl-2,5-dimethyl-piperazine-1...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114079(15-(2-Acetylamino-hexanoylamino)-9-benzyl-6-(3-gua...)
Affinity DataKi:  7nMAssay Description:Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134951(CHEMBL409636 | H-Tyr-Val-Nle-c[Asp-His-Phe-Arg-Trp...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121900(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)
Affinity DataKi:  9.90nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389776(CHEMBL2070249)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150829(4-[(N-Cyclohexyl-3,5-dimethyl-piperazine-1-carboxi...)
Affinity DataKi:  11nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50261228(1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389782(CHEMBL2070374)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134955(CHEMBL2370968 | H-Tyr-Val-Nle-Gly-Pro-D-Nal(2')-Ar...)
Affinity DataKi:  14nMAssay Description:Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389774(CHEMBL2070247)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105887(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50389769(BREMELANOTIDE)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134947(CHEMBL2370963 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-D-Na...)
Affinity DataKi:  17nMAssay Description:Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150830(4-[(N-Cyclohexyl-piperazine-1-carboximidoyl)-amino...)
Affinity DataKi:  18nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105876(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)
Affinity DataKi:  18nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105892(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)
Affinity DataKi:  20nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150833(4-[((S)-N-Cyclohexyl-3-methyl-piperazine-1-carboxi...)
Affinity DataKi:  21nMAssay Description:Inhibition of [125I]-NDP-MSH binding to human Melanocortin 5 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105890(12-Amino-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)
Affinity DataKi:  24nMAssay Description:Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165933(CHEMBL428326 | GPYRMEHFRWGSPPKD-NH2)
Affinity DataKi:  25nMAssay Description:Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50592974(CHEMBL5180727)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells by Topcount beta counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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