TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 2.20E+3nMAssay Description:Inhibition of SHP1 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 9.70E+3nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 1.40E+4nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 1.60E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 1.70E+4nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 2.80E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 2.90E+4nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 6.00E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 8.00E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 9.40E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 1.00E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: >2.00E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 2.89E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 3.50E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: 5.10E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of PTPN6 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assa...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of human SHP1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 355nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 910nMAssay Description:Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.44E+3nMAssay Description:For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP1 (222 to 535 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.43E+3nMpH: 8.0Assay Description:Inhibition of human recombinant SHP1 in Tris buffer at pH 8 using OMPF as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human SHP1 using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University
Curated by ChEMBL
Inha University
Curated by ChEMBL
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair