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Found 322 Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase subunit beta'
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355756(CHEMBL1909658)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355755(CHEMBL1911296)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50391000(CB-01-11 | RIFAMYCIN)
Affinity DataIC50:  20nMT: 2°CAssay Description:Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355751(CHEMBL1911286)
Affinity DataIC50:  21nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50391000(CB-01-11 | RIFAMYCIN)
Affinity DataIC50:  30nMT: 2°CAssay Description:Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355758(CHEMBL1911306)
Affinity DataIC50:  139nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592137(US11572337, Compound 0MTK149)
Affinity DataIC50:  140nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355757(CHEMBL1911298)
Affinity DataIC50:  142nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta'(Escherichia coli K-12)
TBA

Curated by ChEMBL
LigandPNGBDBM43866(2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,1...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Escherichia coli DNA-dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592141(US11572337, Compound 0MTK158)
Affinity DataIC50:  220nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592173(US11572337, Compound 0MTK267)
Affinity DataIC50:  300nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592161(US11572337, Compound 0MTK237)
Affinity DataIC50:  310nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50155485(CHEMBL184023 | Myxopyronin B | methyl (E)-5-(5-((2...)
Affinity DataIC50:  340nMAssay Description:In vitro inhibitory activity against RNA polymerase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592133(US11572337, Compound 0MTK127)
Affinity DataIC50:  370nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592145(US11572337, Compound 0MTK176)
Affinity DataIC50:  390nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592132(US11572337, Compound 0MTK107)
Affinity DataIC50:  400nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592142(US11572337, Compound 0MTK174)
Affinity DataIC50:  410nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592138(US11572337, Compound 0MTK154)
Affinity DataIC50:  420nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592144(US11572337, Compound 0MTK175)
Affinity DataIC50:  450nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Mycobacterium tuberculosis)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50355753(CHEMBL1911289)
Affinity DataIC50:  503nMAssay Description:Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592146(US11572337, Compound 0MTK178)
Affinity DataIC50:  610nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592164(US11572337, Compound 0MTK256)
Affinity DataIC50:  650nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592135(US11572337, Compound 0MTK146)
Affinity DataIC50:  690nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592175(US11572337, Compound 0MTK269)
Affinity DataIC50:  700nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592159(US11572337, Compound 0MTK232)
Affinity DataIC50:  720nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592162(US11572337, Compound 0MTK238)
Affinity DataIC50:  770nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592166(US11572337, Compound 0MTK260)
Affinity DataIC50:  780nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592139(US11572337, Compound 0MTK155)
Affinity DataIC50:  790nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592165(US11572337, Compound 0MTK257)
Affinity DataIC50:  800nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592174(US11572337, Compound 0MTK268)
Affinity DataIC50:  800nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592136(US11572337, Compound 0MTK148)
Affinity DataIC50:  800nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592140(US11572337, Compound 0MTK156)
Affinity DataIC50:  820nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592170(US11572337, Compound 0MTK264)
Affinity DataIC50:  820nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592147(US11572337, Compound 0MTK180)
Affinity DataIC50:  830nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50155484(CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-...)
Affinity DataIC50:  920nMAssay Description:In vitro inhibitory activity against RNA polymerase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592134(US11572337, Compound 0MTK128)
Affinity DataIC50:  970nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50155487(CHEMBL185900 | {(E)-5-[4-Hydroxy-5-((2E,4E)-2-meth...)
Affinity DataIC50:  1.04E+3nMAssay Description:In vitro inhibitory activity against RNA polymerase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592172(US11572337, Compound 0MTK266)
Affinity DataIC50:  1.20E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM50155484(CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-...)
Affinity DataIC50:  1.26E+3nMAssay Description:In vitro inhibitory activity against RNA polymerase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592171(US11572337, Compound 0MTK265)
Affinity DataIC50:  1.30E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592169(US11572337, Compound 0MTK263)
Affinity DataIC50:  1.30E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592148(US11572337, Compound 0MTK181)
Affinity DataIC50:  1.40E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592167(US11572337, Compound 0MTK261)
Affinity DataIC50:  1.50E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta'()
Rutgers, The State University Of New Jersey

US Patent
LigandPNGBDBM592137(US11572337, Compound 0MTK149)
Affinity DataIC50:  1.50E+3nMAssay Description:Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta'()
Rutgers, The State University Of New Jersey

US Patent
LigandPNGBDBM592133(US11572337, Compound 0MTK127)
Affinity DataIC50:  1.50E+3nMAssay Description:Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592168(US11572337, Compound 0MTK262)
Affinity DataIC50:  1.50E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM592149(US11572337, Compound 0MTK183)
Affinity DataIC50:  1.70E+3nMAssay Description:Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta'()
Rutgers, The State University Of New Jersey

US Patent
LigandPNGBDBM592173(US11572337, Compound 0MTK267)
Affinity DataIC50:  1.70E+3nMAssay Description:Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta'()
Rutgers, The State University Of New Jersey

US Patent
LigandPNGBDBM592141(US11572337, Compound 0MTK158)
Affinity DataIC50:  1.80E+3nMAssay Description:Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-directed RNA polymerase subunit beta(Escherichia coli)
Merck

LigandPNGBDBM228835(MRL-436)
Affinity DataIC50:  2.00E+3nMT: 2°CAssay Description:Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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