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Found 388 Enz. Inhib. hit(s) with Target = 'Adenosylhomocysteinase'
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of SAH hydrolase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50240434(2-[1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-propenal |...)
Affinity DataKi:  0.5nMAssay Description:Compound was tested for inhibition of S-adenosyl homocysteine (SAH) hydrolase .More data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50050862(CHEMBL3322562)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound was tested against L929 cells AdoHcy hydrolase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50029130(Adenosine dialdehyde | CHEMBL165876)
Affinity DataKi:  3.30nMAssay Description:Compound was tested for inhibition of S-adenosyl homocysteine (SAH) hydrolase .More data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  3.80nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  3.80nMAssay Description:Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  3.80nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50367250(3-DEAZAARISTEROMYCIN A | CHEMBL268272)
Affinity DataKi:  4nMAssay Description:Binding affinity against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50006222((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)
Affinity DataKi:  8.40nMAssay Description:Reversible inhibition of rat liver S- adenosyl-L-homocysteine hydrolase using SAH as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50034176(4-(6-Amino-purin-9-yl)-cyclopentane-1,2,3-triol | ...)
Affinity DataKi:  11.1nMAssay Description:Binding affinity of the compound was tested against L929 cells AdoHcy hydrolase activityMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006218((1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006220(3-(6-Amino-purin-9-yl)-5-vinyl-cyclopentane-1,2-di...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006221(3-(6-Amino-purin-9-yl)-5-methyl-cyclopentane-1,2-d...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50405655(CHEMBL147260)
Affinity DataKi:  35nMAssay Description:Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280299((2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  39nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50051436((2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy...)
Affinity DataKi:  39nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  39nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  39nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50046747(2-(6-Amino-purin-9-yl)-5-fluoromethylene-tetrahydr...)
Affinity DataKi:  39nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50051436((2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy...)
Affinity DataKi:  39nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280301((2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  40nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50046748(2-(6-Amino-purin-9-yl)-5-fluoromethylene-tetrahydr...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006215((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Affinity DataKi:  41nMAssay Description:Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50051436((2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy...)
Affinity DataKi:  43nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against recombinant rat liver S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  43nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50006215((1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)...)
Affinity DataKi:  49nMAssay Description:Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50008288((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-((R)-1-hydroxy...)
Affinity DataKi:  86nMAssay Description:Inhibitory effect of the compound against L929 Cell S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280300((1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  87nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023889(5-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-pent-3-ene-...)
Affinity DataKi:  90nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50369258(CHEMBL606276)
Affinity DataKi:  95nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50368896(CHEMBL608056)
Affinity DataKi:  96nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50369257(CHEMBL605902)
Affinity DataKi:  101nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50407233(CHEMBL2092790)
Affinity DataKi:  110nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50088426((1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataKi:  110nMAssay Description:Binding affinity against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023879(2-[2-(6-Amino-purin-9-yl)-ethylidene]-propane-1,3-...)
Affinity DataKi:  110nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50369255(CHEMBL605900)
Affinity DataKi:  111nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280298((1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth...)
Affinity DataKi:  112nMAssay Description:Compound was tested for its inhibitory activity against recombinant rat liver S-adenosylhomocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50011148((Z)-4-(6-Amino-purin-9-yl)-but-2-en-1-ol | 4-(6-Am...)
Affinity DataKi:  125nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50407232(CHEMBL2092789)
Affinity DataKi:  134nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50006223(5-(6-Amino-purin-9-yl)-3-methyl-cyclopent-3-ene-1,...)
Affinity DataKi:  150nMAssay Description:Inhibitory effect of the compound against L929 Cell S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023885(4-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-but-2-yn-1-...)
Affinity DataKi:  160nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023886(2-[2-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-ethylide...)
Affinity DataKi:  166nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023887(4-(6-Amino-purin-9-yl)-2-methyl-but-2-en-1-ol | CH...)
Affinity DataKi:  170nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023882(5-(6-Amino-purin-9-yl)-pent-3-ene-1,2-diol | CHEMB...)
Affinity DataKi:  200nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50023877(4-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-but-2-en-1-...)
Affinity DataKi:  200nMAssay Description:Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50408149(CHEMBL2093112)
Affinity DataKi:  224nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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