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Found 8 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase WNK3'
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50466038(CHEMBL4281823)
Affinity DataIC50:  97nMAssay Description:Inhibition of recombinant human WNK3 (1 to 434 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50:  99.8nMAssay Description:Inhibition of WNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3 [1-434](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  377nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50:  401nMAssay Description:Inhibition of WNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50563891(CHEMBL4793380)
Affinity DataIC50:  494nMAssay Description:Inhibition of recombinant human WNK3 (1 to 434 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma33P]ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of human WNK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human WNK3 (1 to 434 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma33P]ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human WNK3 using MBP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed