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Found 44 Enz. Inhib. hit(s) with Target = 'Sphingolipid delta(4)-desaturase DES1'
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523251(N-(5-hydroxy- pyridin-2-yl)-7- methyloctan- amide ...)
Affinity DataIC50:  1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523252((1r,4r)-4-(4- chlorophenyl)- N-(5-hydroxy- pyridin...)
Affinity DataIC50:  1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523268(N-(5-hydroxypyridin-2-yl)-1-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  2nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523246(N-(5-hydroxy- pyridin-2-yl)- 4'-chloro- biphenyl-4...)
Affinity DataIC50:  3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523270(2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]-N-(5-hy...)
Affinity DataIC50:  3.90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523254(4-(tert-butyl)- N-(5-hydroxy- pyridin-2-yl)- benza...)
Affinity DataIC50:  4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523243(N-(5-hydroxy- pyridin-2-yl)- 4-cyclohexyl- benzami...)
Affinity DataIC50:  4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523249((1r,4r)-N-(5- hydroxy- pyridin-2-yl)- 4-phenyl- cy...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523245(N-(5-hydroxy- pyridin-2-yl)- 4'-cyano- biphenyl-4-...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523266(2-[1-(4-chlorophenyl)piperidin-4-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523250(N-(5-hydroxy- pyridin-2-yl)- octanamide | US111352...)
Affinity DataIC50:  6nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523236(N-(5-hydroxy- pyridin-2-yl)- (1,1'- biphenyl)-4- c...)
Affinity DataIC50:  10nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523269(1-(4-fluorophenyl)-N-(5-hydroxypyridin-2-yl)piperi...)
Affinity DataIC50:  11nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523264(2-[1-(4-fluorophenyl) piperidin-4-yl]-N-(5-hydroxy...)
Affinity DataIC50:  13nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523244(N-(5-hydroxy- pyridin-2-yl)- 4'-methoxy- biphenyl-...)
Affinity DataIC50:  14nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523248(N-(5-hydroxy- pyridin-2-yl)- 4-isopropyl- benzamid...)
Affinity DataIC50:  16nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523256(2'-chloro-N- (5-hydroxy- pyridin-2-yl)- [1,1'- bip...)
Affinity DataIC50:  19nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523257((1r,4r)-N-(5- hydroxypyridin- 2-yl)-4-iso- propoxy...)
Affinity DataIC50:  21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523255(N-(5-hydroxy- pyridin-2-yl)- 5-isopropoxy- pentana...)
Affinity DataIC50:  21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523261(N-(5-hydroxy- pyridin-2-yl)- 4-(1,1,1- trifluoro- ...)
Affinity DataIC50:  23nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523232(N-(4-hydroxy- phcnyl)-[1,1'- biphenyl]-4- carboxam...)
Affinity DataIC50:  50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523262(N-(5-hydroxypyridin-2-yl)-2-[4-[4-(trifluoromethyl...)
Affinity DataIC50:  50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523235(N-(5-hydroxy- pyridin-2-yl)- cinnamide | US1113520...)
Affinity DataIC50:  60nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523260(N-(5-hydroxy- pyridin-2-yl)- 4-(trifluoro- methyl)...)
Affinity DataIC50:  63nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523267(2-[4-(4-chlorophenyl)piperazin-1-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  66nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523258((1s,4s)-N-(5- hydroxypyridin- 2-yl)-4-iso- propoxy...)
Affinity DataIC50:  88nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523241(N-(4-hydroxy- phenyl)-4- cyclohexyl- benzamide | U...)
Affinity DataIC50:  90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523253(N-(5-hydroxy- pyridin-2-yl)- 4-(pyridin-3- yl)benz...)
Affinity DataIC50:  130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523259(4-ethyl-N-(5- hydroxy- pyridin-2-yl)- benzamide | ...)
Affinity DataIC50:  130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523265(2-[4-(4-fluorophenyl)piperazin-1-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  140nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523234(N-(5-hydroxy- pyridin-2-yl)- 2-naphth- amide | US1...)
Affinity DataIC50:  180nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523237((trans)-N-(5- hydroxy- pyridin-2-yl)- 2-phenyl- cy...)
Affinity DataIC50:  230nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523247(N-(5-hydroxy- pyridin-2-yl)- 4-methoxy- benzamide ...)
Affinity DataIC50:  240nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523263(1-(4-fluorophenyl)-N-(5-hydroxypyridin-2-yl)piperi...)
Affinity DataIC50:  250nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  440nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523233((trans)-N-(4- hydroxyphenyl)- 2-phenyl- cyclopropa...)
Affinity DataIC50:  590nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523229(N-(4-hydroxy- phenyl)-2- naphthamide | US11135207,...)
Affinity DataIC50:  840nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523230((E)-N-(4- hydroxy- phenyl)-3- phenylbut-2- enamide...)
Affinity DataIC50:  4.46E+3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523242(N-(5-hydroxy- pyridin-2-yl)- phenyl- acetamide | U...)
Affinity DataIC50:  4.50E+3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523239(N-(4-hydroxy- phenyl)-1- napthamide | US11135207, ...)
Affinity DataIC50:  8.20E+3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523238(N-(4-hydroxy- phenyl)-3- methyl-2- butenamide | US...)
Affinity DataIC50: >1.00E+4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523240(N-(4-hydroxy- phenyl)-1H- indazole-5- carboxamide ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM50382314(CHEMBL2024680)
Affinity DataIC50:  1.81E+4nMAssay Description:Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM50382314(CHEMBL2024680)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed