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Found 27 Enz. Inhib. hit(s) with Target = 'Thyrotropin receptor'
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)
Affinity DataIC50:  12nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189329((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50:  47nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM189327(Hexanoic acid (Compound A) | US9174940, Compound A)
Affinity DataIC50:  88nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60849(US9174940, 12)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60850(US9174940, 13)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60851(US9174940, 18)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60853(US9174940, 27)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60855(US9174940, 28)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60856(US9174940, 29)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60857(US9174940, 30)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60860(US9174940, 31)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60863(US9174940, 33)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60864(US9174940, 34)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60865(US9174940, 35)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60866(US9174940, 36)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60867(US9174940, 37)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60869(US9174940, 38)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60870(US9174940, 39)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60872(US9174940, 40)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60847(US9174940, 7)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60845(US9174940, 6)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60843(US9174940, 1)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM60844(US9174940, 4)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50189778(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Affinity DataEC50:  6.50E+3nMAssay Description:Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed