Compile Data Set for Download or QSAR
maximum 50k data
Found 874 Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1'
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341451(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(3...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341466(5-(6-(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)ac...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341518(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(2-me...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341523(1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341652(5-(6-(2-(2-chloro-4-(methylsulfonamido)phenoxy)-ac...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341713(1-(6-Chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-2-me...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341725(2-((6-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-chl...)
Affinity DataIC50:  2nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341346(1-(5-(4-chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341391(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341396(2-((2-chloro-6-(dimethylamino)pyridin-3-yl)oxy)-1-...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341430(6-chloro-5-(2-(5-(5-cyclopropyl-3-fluoropyridin-2-...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341638(N-(6-chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-7,8-...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341710(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341714(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341715(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341724(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341728(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  3nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341327(2-(2-chloro-4-(morpholinomethyl)phenoxy)-1-(5-(2-f...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341333(1-(5-(4-chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341348(2-((4-chloro-2-(dimethylamino)pyrimidin-5-yl)oxy)-...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341387(1-(5-(4-cyclopropyl-2-fluorophenyl)-2-methyl-7,8-d...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341399(6-chloro-5-(2-(5-(4-cyclopropyl-2-fluorophenyl)-2-...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341419(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(2-me...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341423(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(5...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341431(2-((2-chloro-5-fluoro-6-morpholinopyridin-3-yl)oxy...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341432(2-((2-chloro-6-(methyl(2,2,2-trifluoroethyl)amino)...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341476((R)-6-chloro-5-(2-(5-(5-(dimethylcarbamoyl)-3-fluo...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341524(1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341617(1-(5-(3,4-dimethoxyphenyl)-7,8-dihydrothiazolo-[2'...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341629(1-(5-(2-fluoro-4-methoxyphenyl)-7,8-dihydrothiazol...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341632(1-((5R)-5-(4-chloro-2-fluorophenyl)-4a,5-dihydro-t...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341636(1-(5-(4-chloro-2-fluorophenyl)-7,8-dihydrothiazolo...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341644(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341726(1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341334(1-(5-(4-chloro-2-fluorophenyl)-2-methyl-7,8-dihydr...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341341(6-chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-2-methy...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341342(6-chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-2-methy...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341347(N-(6-chloro-5-(2-(5-(4-chloro-2-fluorophenyl)-2-me...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341439(1-(5-(6-chloro-2-fluoropyridin-3-yl)-2-methyl-7,8-...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341445(1-(5-(6-chloro-2-fluoropyridin-3-yl)-2-methyl-7,8-...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341450(Methyl 5-(6-(2-((2-chloro-6-morpholinopyridin-3-yl...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341456(6-chloro-5-(2-(5-(3-fluorothiophen-2-yl)-2-methyl-...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341471(5-(6-(2-((2-chloro-6-(3,3-difluoroazetidin-1-yl)py...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341472(6-chloro-5-(2-(5-(5-(dimethylcarbamoyl)-3-fluoroth...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341477(5-(6-(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)ac...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341499(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(3...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341539(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(2-me...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341557(2-((2-chloro-6-(1,1-dioxidoisothiazolidin-2-yl)pyr...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341569(2-((2-chloro-6-(1,1-dioxidoisothiazolidin-2-yl)pyr...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM341572((R)-1-(5-(2,4-dimethylthiazol-5-yl)-2-methyl-7,8-d...)
Affinity DataIC50:  5nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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