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Found 340 Enz. Inhib. hit(s) with Target = 'cGMP-dependent protein kinase 1'
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  480nM ΔG°:  -36.7kJ/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM92607(H-88)
Affinity DataKi:  760nM ΔG°:  -35.5kJ/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM86727(1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl...)
Affinity DataKi:  5.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKG1A (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human PKG1alpha using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PKG1alpha using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human PKG1beta using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human PKG1beta using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PRKG1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50:  17nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  18nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  18nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597473(CHEMBL5181094)
Affinity DataIC50:  39nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)
Affinity DataIC50:  42nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human PKG1alpha by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataIC50:  69nMAssay Description:Inhibition of PRKG1betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataIC50:  98nMAssay Description:Inhibition of PRKG1alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50:  220nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280868(12-(2,3-dihydroxypropyl)-6,7,12,13-tetrahydro-5H-i...)
Affinity DataIC50:  280nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280877(2-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Affinity DataIC50:  320nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50:  320nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM10840(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Affinity DataIC50:  400nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280876(12-methyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Affinity DataIC50:  400nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3036(23-[3-(dimethylamino)propyl]-3,13,23-triazahexacyc...)
Affinity DataIC50:  420nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50:  517nMAssay Description:Inhibition of recombinant full length human PKG1alpha using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP and 10 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM10842(3-(2-aminopyrimidin-4-yl)-7-bromo-1H-indol-4-ol | ...)
Affinity DataIC50:  600nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM10843(4-(5,6-dibromo-1H-indol-3-yl)pyrimidin-2-amine | M...)
Affinity DataIC50:  600nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM2581(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Affinity DataIC50:  650nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50:  660nMAssay Description:Inhibition of recombinant full length human PKG1beta using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP by radiometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280879(12,13-diethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a...)
Affinity DataIC50:  700nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280870(12-(2,2-difluoroethyl)-13-methyl-6,7,12,13-tetrahy...)
Affinity DataIC50:  710nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM10841(4-(6-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Affinity DataIC50:  800nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3039(23-[3-(dimethylamino)propyl]-3-methyl-3,13,23-tria...)
Affinity DataIC50:  870nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50525788(CHEMBL4474940)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50525788(CHEMBL4474940)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1beta expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50182362(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1beta expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50182362(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50284317(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Tested for inhibition of cGMP-dependent protein kinase from bovine lungMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM10839(3-(2-aminopyrimidin-4-yl)-6-bromo-1H-indol-4-ol | ...)
Affinity DataIC50:  1.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3047(4-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50:  1.00E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM50280873(2-(13-ethyl-5-oxo-6,7,12,13-tetrahydro-5H-indolo[2...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597485(CHEMBL5183751)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50382218(CHEMBL2023842)
Affinity DataIC50:  1.86E+3nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human PKG1alpha by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3034(3-{7,19-dimethoxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50:  2.00E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50:  2.10E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  2.25E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Nagoya University School Of Medicine

LigandPNGBDBM50597490(CHEMBL5199904)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Tumor Biology Center

LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50: >3.00E+3nMAssay Description:Tested for inhibition of cGMP-dependent protein kinase from bovine lungMore data for this Ligand-Target Pair
In DepthDetails Article
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