Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with Target = 'Glutamate carboxypeptidase 2 [44-750]'
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17759((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Affinity DataIC50:  0.100nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17775(3-(1-carboxy-4-sulfanylbutoxy)benzoic acid | Thiol...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17758((2R)-2-(phosphonomethyl)pentanedioic acid | (R)-2-...)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17776(3-[(1-carboxy-4-sulfanylbutyl)sulfanyl]benzoic aci...)
Affinity DataIC50:  32nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17754((2S)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50:  34nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17763(4-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  63nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17757((2S)-2-(3-sulfanylpropyl)pentanedioic acid | (S)-2...)
Affinity DataIC50:  67nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataIC50:  82nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataIC50:  82nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17756((2R)-2-(3-sulfanylpropyl)pentanedioic acid | (R)-2...)
Affinity DataIC50:  85nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17777(3-[2-carboxy-2-(phosphonomethyl)ethyl]benzoic acid...)
Affinity DataIC50:  120nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17767(3-[2-carboxy-2-(5-sulfanylpentyl)ethyl]benzoic aci...)
Affinity DataIC50:  190nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17779(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17766(3-[2-carboxy-2-(4-sulfanylbutyl)ethyl]benzoic acid...)
Affinity DataIC50:  390nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17764(3-[2-carboxy-2-(sulfanylmethyl)ethyl]benzoic acid ...)
Affinity DataIC50:  440nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17771(3-[2-carbamoyl-2-(3-sulfanylpropyl)ethyl]benzoic a...)
Affinity DataIC50:  640nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17770(3-[3-methoxy-3-oxo-2-(3-sulfanylpropyl)propyl]benz...)
Affinity DataIC50:  730nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17765(3-[2-carboxy-2-(2-sulfanylethyl)ethyl]benzoic acid...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17753((2R)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17760(2-benzyl-5-sulfanylpentanoic acid | Thiol-Based In...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17761(2-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17774(2-[(3-cyanophenyl)methyl]-5-sulfanylpentanoic acid...)
Affinity DataIC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17773(2-[(3-carbamoylphenyl)methyl]-5-sulfanylpentanoic ...)
Affinity DataIC50:  2.20E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17778(3-[2-carboxy-2-({hydroxy[(2,3,4,5,6-pentafluorophe...)
Affinity DataIC50:  2.40E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17772(2-{[3-(methoxycarbonyl)phenyl]methyl}-5-sulfanylpe...)
Affinity DataIC50:  2.70E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataIC50:  9.50E+3nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17780(3-{2-carboxy-2-[(hydroxycarbamoyl)methyl]ethyl}ben...)
Affinity DataIC50:  1.50E+4nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17782(2-[(3-carboxyphenyl)methyl]butanedioic acid | carb...)
Affinity DataIC50:  1.50E+4nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17768(3-{2-carboxy-2-[3-(methylsulfanyl)propyl]ethyl}ben...)
Affinity DataIC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17769(3-(2-carboxy-2-{3-[(triphenylmethyl)sulfanyl]propy...)
Affinity DataIC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17781(CHEMBL65860 | butane-1,2,4-tricarboxylic acid | ca...)
Affinity DataIC50:  2.00E+4nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17661((2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimi...)
Affinity DataIC50:  6.70E+4nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM107672((S)-2-((N-((S)-2-benzamido-2-carboxyethyl) sulfamo...)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Inhibitors were made in TRIS buffer (50mM Tris pH 7.4 containing 1% Triton X-100). Working solutions of purified GCPII (50ug/mL) were diluted in TRI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataIC50:  4.28E+5nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17663((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...)
Affinity DataIC50:  4.38E+5nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17664((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Affinity DataIC50:  5.23E+5nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17662((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Affinity DataIC50: >1.00E+7nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed