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Found 166 Enz. Inhib. hit(s) with Target = 'Interleukin-6'
TargetInterleukin-6 receptor subunit alpha(Rattus norvegicus)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity of the compound was measured on leukotriene-6 receptor using [3H]- IL-6 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit alpha(Rattus norvegicus)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity was measured on leukotriene-6 receptor using [3H]- IL-6 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM414420((R)-7-[4-(2-ethoxycarbonyl-2-hydroxyethyl)oxy-2-me...)
Affinity DataIC50: <1nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331838((R)-7-[4-(2-ethoxycarbonyl-2-hydroxyethyl)oxy-2-me...)
Affinity DataIC50: <1nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140015(US8901310, Comparator E)
Affinity DataIC50:  1.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140013(US8901310, Comparator C)
Affinity DataIC50:  1.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140014(US8901310, Comparator D)
Affinity DataIC50:  1.30nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140017(US8901310, Comparator G)
Affinity DataIC50:  2.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140019(US8901310, Comparator I)
Affinity DataIC50:  2.80nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM65497(CC-220 (Compound 6) | US9694015, 6.4S)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140012(US8901310, Comparator B)
Affinity DataIC50:  4nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50:  4.20nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140018(US8901310, Comparator H)
Affinity DataIC50:  4.30nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140016(US8901310, Comparator F)
Affinity DataIC50:  7nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM77001(3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoisoin...)
Affinity DataIC50:  10nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331841((S)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  13nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331841((S)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  13nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331840((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  14nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331840((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50:  14nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331839((S)-7-[4-(2,4-dihydroxybutyl)oxy-2-methoxyphenyl]-...)
Affinity DataIC50:  15nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331839((S)-7-[4-(2,4-dihydroxybutyl)oxy-2-methoxyphenyl]-...)
Affinity DataIC50:  15nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331836((S)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50:  33nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331836((S)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50:  33nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331837((R)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50:  34nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331837((R)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50:  34nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataIC50: >36.4nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM65456(19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...)
Affinity DataIC50:  59nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140010(US8901310, Example 2)
Affinity DataIC50:  60nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM76986(3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-pipe...)
Affinity DataIC50:  60nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331842(7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-met...)
Affinity DataIC50:  83nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331842(7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-met...)
Affinity DataIC50:  83nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM77015((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...)
Affinity DataIC50:  83nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331844(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxy-2-...)
Affinity DataIC50:  93nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331844(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxy-2-...)
Affinity DataIC50:  93nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331843(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxymet...)
Affinity DataIC50:  123nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM331843(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxymet...)
Affinity DataIC50:  123nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM50349518(BERGENIN)
Affinity DataIC50:  208nMAssay Description:Inhibition of IL6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM140020(US8901310, Comparator J)
Affinity DataIC50:  291nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM65454(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Affinity DataIC50:  1.20E+3nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145177(CHEMBL3764956)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM50252381(CHEMBL4080826)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145193(CHEMBL3765505)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145178(CHEMBL3764721)
Affinity DataIC50:  6.38E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145189(CHEMBL3764217)
Affinity DataIC50:  6.55E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145194(CHEMBL3765178)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145192(CHEMBL3765653)
Affinity DataIC50:  9.33E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM50070114((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a â¿¿20° C. freezer p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-6(Homo sapiens (Human))
Santen Pharmaceutical

US Patent
LigandPNGBDBM50252380(CHEMBL4068283)
Affinity DataIC50:  1.89E+4nMAssay Description:Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145179(CHEMBL3764020)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-6 receptor subunit beta(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50145180(CHEMBL3763273)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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