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Found 68 Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 8'
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  1.30nM IC50:  5nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  17nM IC50:  42nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi:  1.50E+3nM IC50:  3.00E+3nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50243294(CHEMBL4094513)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PRMT8 (unknown origin) incubated for 15 mins followed by substrate addition measured after 60 mins by AlphaLisa methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095355(CHEMBL3589029)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT8 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT8 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human PRMT8 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095354(CHEMBL3589030)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095432(CHEMBL3589026)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095356(CHEMBL3589028)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095353(CHEMBL3589031)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095357(CHEMBL3589027)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095347(CHEMBL3589037)
Affinity DataIC50:  21nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095352(CHEMBL3589032)
Affinity DataIC50:  22nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095351(CHEMBL3589033)
Affinity DataIC50:  22nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095348(CHEMBL3589036)
Affinity DataIC50:  23nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095433(CHEMBL3589913)
Affinity DataIC50:  28nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095442(CHEMBL3589038)
Affinity DataIC50:  44nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095350(CHEMBL3589034)
Affinity DataIC50:  55nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095435(CHEMBL3590417)
Affinity DataIC50:  65nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095434(CHEMBL3589912)
Affinity DataIC50:  67nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095349(CHEMBL3589035)
Affinity DataIC50:  70nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50511923(CHEMBL4463793)
Affinity DataIC50:  110nMAssay Description:Inhibition of human PRMT8 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50511921(CHEMBL4544587)
Affinity DataIC50:  130nMAssay Description:Inhibition of human PRMT8 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095438(CHEMBL3589042)
Affinity DataIC50:  179nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095441(CHEMBL3589039)
Affinity DataIC50:  223nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095436(CHEMBL3589043)
Affinity DataIC50:  347nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095440(CHEMBL3589040)
Affinity DataIC50:  450nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50194758(CHEMBL3970878)
Affinity DataIC50:  573nMAssay Description:Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50095439(CHEMBL3589041)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50070953(CHEMBL3409550)
Affinity DataIC50:  1.74E+3nMAssay Description:Displacement of [3H]-SAM from recombinant His6-tagged PRMT8 (unknown origin) expressed in Escherichia coli BL21(DE3) incubated for 5 mins prior to H4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50194772(CHEMBL3955728)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human PRMT8 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598018(CHEMBL5180108)
Affinity DataIC50:  3.82E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598019(CHEMBL5186617)
Affinity DataIC50:  5.84E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598017(CHEMBL5206272)
Affinity DataIC50:  5.87E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50532871(CHEMBL4470484)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50532871(CHEMBL4470484)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50158095(CHEMBL3780444)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human PRMT8 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50550091(CHEMBL4648477)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of recombinant His-tagged human PRMT8 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 peptide as substrate inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50598015(CHEMBL5199380)
Affinity DataIC50:  8.29E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50532860(CHEMBL4445795)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50532860(CHEMBL4445795)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50158097(CHEMBL3780701)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human PRMT8 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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