Compile Data Set for Download or QSAR
maximum 50k data
Found 107 Enz. Inhib. hit(s) with Target = 'N-lysine methyltransferase KMT5A'
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50201571(CHEMBL3934996)
Affinity DataKi:  50nMAssay Description:Competitive inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of SETD8 (unknown origin) using H4 (1 to 24) as substrate assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of varying levels of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataIC50:  210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataIC50:  210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50201571(CHEMBL3934996)
Affinity DataIC50:  330nMAssay Description:Inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-SAM by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50086655(2-Methyl-5-p-tolylamino-benzothiazole-4,7-dione | ...)
Affinity DataIC50:  370nMAssay Description:Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50086655(2-Methyl-5-p-tolylamino-benzothiazole-4,7-dione | ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50075099(CHEMBL580421 | TCMDC-124224)
Affinity DataIC50:  700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50075099(CHEMBL580421 | TCMDC-124224)
Affinity DataIC50:  700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50548177(CHEMBL4791952)
Affinity DataIC50:  804nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50548178(CHEMBL4793474)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotinylated-H3 peptide as substrate measured after 1 hr in presence of [3H]-SAM by scintillation proximit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using H4 (1 to 24) as substrate assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to peptide subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate incubated for 1 hr in presence of [3H-Me]SAM by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of [3H]SAM by scintillation proxi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50548177(CHEMBL4791952)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498700(CHEMBL3621706)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051122(CHEMBL3318290)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051121(CHEMBL3318289)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498722(CHEMBL3621701)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498721(CHEMBL3621704)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of methyltransferase activity of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli assessed as decrease in methylation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051133(CHEMBL3318301)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498730(CHEMBL3622290)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50353131(CHEMBL1829304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SETD8 assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498718(CHEMBL3622293)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498725(CHEMBL3622271)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051123(CHEMBL3318291)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498731(CHEMBL3621703)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051127(CHEMBL3318295)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498696(CHEMBL3622261)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051126(CHEMBL3318294)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051125(CHEMBL3318293)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051128(CHEMBL3318296)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051124(CHEMBL3318292)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051119(CHEMBL3318287)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051386(CHEMBL3318305)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051384(CHEMBL3318304)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50:  3.77E+4nMAssay Description:Displacement of FITC-labeled H4K20me (1-24) from SETD8 (unknown origin) catalytic domain expressed in Escherichia coli by fluorescence polarization a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50536815(CHEMBL4568659)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate in presence of [3H-Me]SAM by scintillation proxi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498727(CHEMBL3622262)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50498720(CHEMBL3621702)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50300041(7-(3-(dimethylamino)propoxy)-6-methoxy-2-(4-methyl...)
Affinity DataIC50: >4.00E+4nMAssay Description:Activity at methyl transferase activity SET8/preSet7 by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50323813(7-(2-(2-(Dimethylamino)ethoxy)ethoxy)-6-methoxy-2-...)
Affinity DataIC50: >4.00E+4nMAssay Description:Activity at methyl transferase activity SET8/preSet7 by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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