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Found 2079 Enz. Inhib. hit(s) with Target = 'Sigma intracellular receptor 2'
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312199(US9604926, Compound CM-366)
Affinity DataKi:  0.00600nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM330349(US9724435, Compound CM-366)
Affinity DataKi:  0.00600nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312198(US9604926, Compound CM-365 | US9724435, Compound C...)
Affinity DataKi:  0.0550nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312198(US9604926, Compound CM-365 | US9724435, Compound C...)
Affinity DataKi:  0.0550nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM532343(US11214540, Example 1)
Affinity DataKi:  0.200nMAssay Description:The affinity of test compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled sigma-2 or sigma-1 lig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  0.210nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50353847(CHEMBL1831157 | US9604926, Compound CM-360 | US972...)
Affinity DataKi:  0.210nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312234(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Affinity DataKi:  0.220nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312234(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Affinity DataKi:  0.220nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50216056((N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranes in presence of (+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50562182(CHEMBL4744466)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50353844(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Affinity DataKi:  0.390nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50353844(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Affinity DataKi:  0.390nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50353844(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Affinity DataKi:  0.390nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50353844(CHEMBL270341 | US9604926, Compound CM-145 | US9724...)
Affinity DataKi:  0.390nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312202(US9604926, Compound CM-397 | US9724435, Compound C...)
Affinity DataKi:  0.460nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312202(US9604926, Compound CM-397 | US9724435, Compound C...)
Affinity DataKi:  0.460nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312235(US9604926, Compound AZ-78 | US9724435, Compound AZ...)
Affinity DataKi:  0.5nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312235(US9604926, Compound AZ-78 | US9724435, Compound AZ...)
Affinity DataKi:  0.5nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50374598(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Affinity DataKi:  0.550nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM50374598(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Affinity DataKi:  0.550nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312185(US9604926, Compound CM-308 | US9724435, Compound C...)
Affinity DataKi:  0.560nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312185(US9604926, Compound CM-308 | US9724435, Compound C...)
Affinity DataKi:  0.560nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50540826(CHEMBL4647871)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-ditolylguanidine from human Sigma 2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM532344(US11214540, Example 2)
Affinity DataKi:  0.600nMAssay Description:The affinity of test compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled sigma-2 or sigma-1 lig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312203(US9604926, Compound CM-401 | US9724435, Compound C...)
Affinity DataKi:  0.660nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312203(US9604926, Compound CM-401 | US9724435, Compound C...)
Affinity DataKi:  0.660nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50536985(CHEMBL4531345)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat brain membranes after 120 mins in presence of (+)-pentazocine by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The University Of Mississippi

US Patent
LigandPNGBDBM312166(US9604926, Compound CM-170 | US9724435, Compound C...)
Affinity DataKi:  0.700nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Mus musculus (Mouse))
The University Of Mississippi

US Patent
LigandPNGBDBM312166(US9604926, Compound CM-170 | US9724435, Compound C...)
Affinity DataKi:  0.700nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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