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Found 433 Enz. Inhib. hit(s) with Target = 'Tyrosinase'
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205807(CHEMBL3978212)
Affinity DataKi:  350nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205807(CHEMBL3978212)
Affinity DataKi:  350nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205807(CHEMBL3978212)
Affinity DataKi:  350nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205815(CHEMBL3907670)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205815(CHEMBL3907670)
Affinity DataKi:  1.02E+3nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205815(CHEMBL3907670)
Affinity DataKi:  1.02E+3nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205806(CHEMBL3969839)
Affinity DataKi:  1.20E+3nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205806(CHEMBL3969839)
Affinity DataKi:  1.20E+3nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205806(CHEMBL3969839)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50240041(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Affinity DataKi:  1.70E+3nMAssay Description:Uncompetitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50206007(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of human tyrosinase expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50414514(PROTOCATECHUAMIDE)
Affinity DataKi:  3.70E+3nMAssay Description:Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50248158(CHEMBL450195 | N-butylresorcinol | US8993596, 4-Bu...)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50198715((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Affinity DataKi:  1.03E+4nMAssay Description:Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50330108(2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-one | CHE...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50330109(5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-one | CH...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50292636(4-hexyl resorcinol | ACRISORCIN | CHEMBL443605)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50330111(5-hydroxy-2-(pentylthiomethyl)-4H-pyran-4-one | CH...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50559094(CHEMBL4751526)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50559095(CHEMBL4746238)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296245(3,4-Dihydroxy-N-[2-(5-hydroxyindol-3-yl)ethyl]benz...)
Affinity DataKi:  6.40E+4nMAssay Description:Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50559087(CHEMBL4794995)
Affinity DataKi:  7.50E+4nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50559088(CHEMBL4777553)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205814(CHEMBL3898657)
Affinity DataKi:  1.28E+5nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205814(CHEMBL3898657)
Affinity DataKi:  1.28E+5nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50205814(CHEMBL3898657)
Affinity DataKi:  1.28E+5nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM29612(CHEMBL33103 | CVD-0001578 | JOH-MSK-a63bdd1d-4 | N...)
Affinity DataKi:  2.40E+5nMAssay Description:Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  3.50E+5nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM197302(Benzoic acid | SAMPL4, O1)
Affinity DataKi:  5.20E+5nMAssay Description:Mixed inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50020713(CHEMBL460860)
Affinity DataKi:  2.50E+6nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 240 uM by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50020713(CHEMBL460860)
Affinity DataKi:  2.80E+6nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataKi:  2.90E+6nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50020713(CHEMBL460860)
Affinity DataKi:  3.10E+6nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 60 uM by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  5.50E+6nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  23nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50287127((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Affinity DataIC50:  60nMAssay Description:Compound was evaluated for inhibition of tyrosinase enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50203985((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50203985((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50251013(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50251013(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...)
Affinity DataIC50:  89nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
National Institute Of Advanced Industrial Science And Technology

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazo...)
Affinity DataIC50:  89nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50441626(GLABRIDIN | US9783551, Compound 1)
Affinity DataIC50:  90nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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