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Found 45 Enz. Inhib. hit(s) with Target = 'Inward rectifier potassium channel 2'
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65870((4-Methoxy-benzyl)-naphthalen-1-ylmethyl-amine | 1...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Kir2.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600745(US11632953, Compound 1 | US11632953, Compound VU04...)
Affinity DataIC50:  1.13E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600745(US11632953, Compound 1 | US11632953, Compound VU04...)
Affinity DataIC50:  1.27E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65858(MLS000557943 | N-[2-[5-[(4-chlorobenzyl)thio]-1,3,...)
Affinity DataIC50:  1.58E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65871(5-bromanyl-N-(1-phenylethyl)thiophene-2-sulfonamid...)
Affinity DataIC50:  1.98E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65874(2-[[2-[(2-hydroxy-5-methyl-benzyl)amino]ethylamino...)
Affinity DataIC50:  2.15E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65865((E)-N-[(4-methoxyphenyl)methyl]-3-phenyl-2-propen-...)
Affinity DataIC50:  2.23E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65861(1-{[3-(3-phenoxyphenoxy)propyl]amino}-2-propanol e...)
Affinity DataIC50:  2.36E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65872(1-[(4-fluorobenzyl)amino]-3-(4-methylphenoxy)propa...)
Affinity DataIC50:  2.46E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65868(4-Bromo-N-(1-phenyl-ethyl)-benzenesulfonamide | 4-...)
Affinity DataIC50:  2.56E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65859(2-Cyclopropyl-1-phenethyl-1H-benzoimidazole | 2-cy...)
Affinity DataIC50:  2.57E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65870((4-Methoxy-benzyl)-naphthalen-1-ylmethyl-amine | 1...)
Affinity DataIC50:  2.69E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50312105(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600754(US11632953, Compound 12 | VU0652942)
Affinity DataIC50: >3.00E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600751(US11632953, Compound 9 | VU0652954)
Affinity DataIC50: >3.00E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600748(US11632953, Compound 5 | VU0650730)
Affinity DataIC50: >3.00E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600747(US11632953, Compound 4 | VU0650729)
Affinity DataIC50: >3.00E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50050539(CHEMBL3187891)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50050534(CHEMBL3183773)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50050530(CHEMBL3188857)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50312125(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM600755(US11632953, Compound 13 | VU0652943)
Affinity DataIC50: >3.00E+4nMAssay Description:The thallium flux assay is an in vitro method of measuring conductance through a potassium ion channel. Potassium channels are also permeable to thal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65863(3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-1H-in...)
Affinity DataIC50:  3.07E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM43753(6-methyl-N-(phenylmethyl)-1H-benzimidazol-2-amine ...)
Affinity DataIC50:  3.34E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65857(3-(4-benzoxyphenoxy)propyl-cyclopentyl-amine;oxali...)
Affinity DataIC50:  3.35E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65855((4-methoxyphenyl)-(4-quinolyl)amine;hydrochloride ...)
Affinity DataIC50:  3.40E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65873((3-bromo-4-methoxy-benzyl)-homopiperonyl-amine;oxa...)
Affinity DataIC50:  3.47E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65856(3-chloranyl-4-(1-ethylbenzimidazol-2-yl)sulfanyl-a...)
Affinity DataIC50:  3.56E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65862(2-[(2,4-dichlorobenzylidene)amino]guanidine | 2-[(...)
Affinity DataIC50:  3.76E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65867((1-benzyl-4-piperidyl)-(4-chlorobenzyl)amine | 1-b...)
Affinity DataIC50:  3.77E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65860(4-(methylthio)-N-(1-phenylethyl)benzenesulfonamide...)
Affinity DataIC50:  4.30E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65869((2,8-Dimethyl-quinolin-4-yl)-p-tolyl-amine | (2,8-...)
Affinity DataIC50:  4.31E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65854(4-[[4-ethyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]s...)
Affinity DataIC50:  4.83E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Kir2.1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Kir2.1 potassium channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65864(1-adamantyl-(1-propyl-4-piperidyl)amine | MLS00097...)
Affinity DataIC50:  5.42E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM65866(1-(4-Fluoro-benzenesulfonyl)-1,2,3,4-tetrahydro-qu...)
Affinity DataIC50:  5.85E+4nMAssay Description:Data Source: Johns Hopkins Ion Channel Center (JHICC) BioAssay Type: Confirmatory, Confirmatory Screening, Multiple Concentration Activity Observed. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50249183(CHEMBL4069245)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50391771(CHEMBL2146754)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Kir2.1 expressed in HEK293 cells assessed as inhibition of thallium efflux by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Kir2.1 expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50204281(CHEMBL3933749)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50391770(CHEMBL2146755 | US9073882, 1)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Kir2.1 expressed in HEK293 cells assessed as inhibition of thallium efflux by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed