Compile Data Set for Download or QSAR
maximum 50k data
Found 1150 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 11'
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252777(CHEMBL523374 | N,6-Dimethyl-7-(1-((S)-3-methylmorp...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50346920(CHEMBL1795686)
Affinity DataKi:  6nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50346919(CHEMBL1795685)
Affinity DataKi:  17nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  24nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  25nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataKi:  25.1nMAssay Description:Inhibition of GST-tagged p38beta by fluorescence polarization methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  25.1nMAssay Description:Inhibition of GST-tagged p38beta by fluorescence polarization methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi:  40nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50418607(CHEMBL1784173)
Affinity DataKi:  158nMAssay Description:Inhibition of GST-tagged p38beta by fluorescence polarization methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKi:  220nMAssay Description:Inhibition of p38beta using KRELVEPLTPSGEAPNQALLR as substrate for 10 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataKi:  320nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM19429(4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...)
Affinity DataKi:  600nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of P38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50605782(CHEMBL5174953)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219316(CHEMBL545353)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222624(CHEMBL357598)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222627(CHEMBL356125)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50605781(CHEMBL5202475)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of wild type p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222628(CHEMBL142697)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LPS-stimulated p38-related TNF-alpha production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50605756(CHEMBL5184542)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222629(CHEMBL142187)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122391(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-(pip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122995((S)-3-(2-(1-methoxypropan-2-ylamino)pyridin-4-yl)-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50476040(CHEMBL219796)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122996(2-Phenyl-3-[2-((S)-1-phenyl-ethylamino)-pyrimidin-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219323(CHEMBL161276)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122389(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222105(CHEMBL92814)
Affinity DataIC50:  0.700nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50492380(CHEMBL2402001)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50209771(3,4-dihydroquinolin-2(1H)-one | CHEMBL388582 | Dih...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of mitogen-activated protein kinase p38 at 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50605761(CHEMBL5197888)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222626(CHEMBL142289)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222619(CHEMBL343682)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of LPS-stimulated p38-related IL1-beta production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50357902(CHEMBL1738839)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50215268(CHEMBL325211)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222622(CHEMBL358108)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222621(CHEMBL142463)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222096(CHEMBL92648)
Affinity DataIC50:  1.20nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1150 total ) | Next | Last >>
Jump to: