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Found 10 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit rho-2'
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50211642(CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium...)
Affinity DataIC50:  2.21E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336850(3-(guanido)-1-oxo-1-hydroxy-phospholane | CHEMBL16...)
Affinity DataIC50:  5.13E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336851(3-(aminomethyl)-1-oxo-1-hydroxy-phospholane | CHEM...)
Affinity DataIC50:  5.71E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM23183(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)
Affinity DataKd:  1.40E+3nMAssay Description:Partial agonist activity against human rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50087277((Z)-4-Amino-but-2-enoic acid | (Z)-4-aminobut-2-en...)
Affinity DataEC50:  7.00E+4nMAssay Description:Partial agonist activity againast human rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50087271((E)-4-Amino-but-2-enoic acid (TACA) | 4-Amino-but-...)
Affinity DataEC50:  400nMAssay Description:Partial agonist activity against homomeric rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50087274(4-Amino-2-methyl-but-2-enoic acid (2-MeTACA) | 4-a...)
Affinity DataEC50:  1.01E+5nMAssay Description:Activation of human rho2 GABA-C receptor at 34% of maximal GABA-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM85712(1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...)
Affinity DataEC50:  3.00E+3nMAssay Description:Partial agonist activity against human rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50087269((cis)-2-Aminomethyl-cyclopropanecarboxylic acid | ...)
Affinity DataEC50:  1.75E+4nMAssay Description:Partial agonist activity with low efficacy against rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit rho-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50087269((cis)-2-Aminomethyl-cyclopropanecarboxylic acid | ...)
Affinity DataEC50:  3.45E+4nMAssay Description:Full agonist activity against human rho-2 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed