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Found 27 Enz. Inhib. hit(s) with Target = 'Gag polyprotein'
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36656(Cyclobutylmethyl cyclic urea)
Affinity DataIC50:  7.80nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36657(2-Naphthylmethyl cyclic urea)
Affinity DataIC50:  12nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataIC50:  13nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  13.1nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  20nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36655(Cyclopropylmethyl cyclic urea)
Affinity DataIC50:  25nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM50124714((4R,5S,6S,7R)-1-(3-Amino-1H-indazol-5-ylmethyl)-4,...)
Affinity DataIC50:  39.5nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36658(n-Pentyl cyclic urea)
Affinity DataIC50:  41nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36646(DMP850)
Affinity DataIC50:  49nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Dupont Pharmaceuticals

LigandPNGBDBM36659(n-Hexyl cyclic urea)
Affinity DataIC50:  130nMpH: 6.5Assay Description:Enzyme inhibition assay using cyclic ureas to inhibit GAG polyprotein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273882(2-[3-chloro-3-phenylprop-2-enylidene]hydrazinecarb...)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273849(1-Chloro-5,7-dimethyl-3,4-dihydronaphthalene-2-car...)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273851(2-[(3-chloro-1H-inden-2-yl)methylene]hydrazinecarb...)
Affinity DataIC50:  1.30E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(1-Chloro-3,4-dihydronaphthalene-2-carboxaldehyde g...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273883(CHEMBL460174 | beta-Chloro-alpha-methylcinnamaldeh...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273850(1-Chloro-3-dihydro-4-methylnaphthalene-2-carboxald...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273848(1-Chloro-6-methoxy-3,4-dihydronaphthalene-2-carbox...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273854(1-Methoxy-3,4-dihydronaphthalene-2-carboxaldehyde ...)
Affinity DataIC50:  3.10E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273852(9-Chloro-6,7-dihydro-5-benzocycloheptene-8-carboxa...)
Affinity DataIC50:  3.30E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273880(1-Phenoxy-3,4-dihydronaphthalene-2-carboxaldehyde ...)
Affinity DataIC50:  3.50E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273847(1-Chloro-7-methoxy-3,4-dihydronaphthalene-2-carbox...)
Affinity DataIC50:  3.90E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50240439(2-(1-Naphthalenylmethylene) hydrazinecarboximidami...)
Affinity DataIC50:  7.50E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50240438(2-(2-Naphthalenylmethylene)hydrazinecarboximidamid...)
Affinity DataIC50:  7.50E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273853(1-Bromo-3,4-dihydronaphthalene-2-carboxaldehyde gu...)
Affinity DataIC50:  7.80E+3nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50273881(1-(1,1,1,-Trifluoromethyl)-3,4-dihydronaphthalene-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50450015(Bms-955176 | GSK-3532795)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to wild type HIV1 gag polyprotein containing viral like particleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag polyprotein(Human immunodeficiency virus 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50450016(CHEMBL4163247)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to wild type HIV1 gag polyprotein containing viral like particleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed