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Found 64 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor [G667C]'
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515356((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...)
Affinity DataIC50:  0.120nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515377((13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7...)
Affinity DataIC50:  0.210nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515357((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...)
Affinity DataIC50:  0.220nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515375((13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-...)
Affinity DataIC50:  0.360nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515361((13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-me...)
Affinity DataIC50:  0.380nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515360((13E,14E,22R,24S)-12-amino-24,35-difluoro- 6,6-dim...)
Affinity DataIC50:  0.400nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515372((13E,14E,22R,5S)-12-amino-35- fluoro-5-methyl-4-ox...)
Affinity DataIC50:  0.430nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647635(T-05 | US20240025908, Example 3)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647639(T-17 | US20240025908, Example 7)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647640(T-36 | US20240025908, Example 8)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647642(T-42 | US20240025908, Example 10)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647638(T-12 | US20240025908, Example 6)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647641(T-37 | US20240025908, Example 9)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515358((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...)
Affinity DataIC50:  0.550nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515354(US11098060, Example 12 | US11098060, Example 34)
Affinity DataIC50:  0.820nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515354(US11098060, Example 12 | US11098060, Example 34)
Affinity DataIC50:  0.880nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: <1nMAssay Description:TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515367(US11098060, Example 26)
Affinity DataIC50:  1.22nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515373((R,13E,14E)-12-amino-35-fluoro- 4-oxa-7-aza-1(5,3)...)
Affinity DataIC50:  1.46nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515350((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...)
Affinity DataIC50:  1.63nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515345(US11098060, Example 1)
Affinity DataIC50:  1.68nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515363(US11098060, Example 21)
Affinity DataIC50:  1.71nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515346((13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-p...)
Affinity DataIC50:  1.86nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)
Affinity DataIC50:  1.89nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515365(US11098060, Example 23)
Affinity DataIC50:  2.39nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515352((R,13E,14E)-12-amino-35-fluro-4-oxa-8-aza- 1(5,3)-...)
Affinity DataIC50:  2.41nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515371((13E,14E,22R,24S)-12-amino- 24,35-difluoro-8-aza-1...)
Affinity DataIC50:  2.43nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647652(US20240025908, Example 20)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647653(US20240025908, Example 21)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647654(US20240025908, Example 22)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647655(US20240025908, Example 23)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647658(US20240025908, Example 26)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647636(T-07 | US20240025908, Example 4)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647634(T-02 | US20240025908, Example 2)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM647633(T-01 | US20240025908, Example 1)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515370((13E,14E,22R,24S,6S)-12-amino- 24,35-difluoro-6-me...)
Affinity DataIC50:  3.16nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515349((R,13E,14E)-12-amino-4-oxa-8-aza-1(5,3)- pyrazolo[...)
Affinity DataIC50:  5.61nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515351((13E,14E,22R,24R)-12-amino-35fluoro-24- hydroxy-4-...)
Affinity DataIC50:  5.74nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515359((13E,14E,22R,24S)-12-amino-24,35-difluoro- 8-methy...)
Affinity DataIC50:  8.07nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515376((13E,14E,22R,24R)-12-amino-35- fluoro-24-hydroxy-4...)
Affinity DataIC50:  8.16nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <10nMAssay Description:TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472759(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <10nMAssay Description:TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515348((R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[...)
Affinity DataIC50:  12.1nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515364(US11098060, Example 22)
Affinity DataIC50:  12.8nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515369((13E,14E,22R,6R)-12-amino-35- fluoro-6-methyl-7-az...)
Affinity DataIC50:  13.4nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515355((13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-...)
Affinity DataIC50:  14.6nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515362(US11098060, Example 20)
Affinity DataIC50:  15.1nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515366((13E,14E)-12-amino-35-fluoro-31,32-dihydro-7- aza-...)
Affinity DataIC50:  16nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515347((13E,14E)-12-amino-4-oxa-8-aza-1(5,3)- pyrazolo[1,...)
Affinity DataIC50:  16.2nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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