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Found 589 Enz. Inhib. hit(s) with Target = 'Hormone-sensitive lipase'
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50064422(CHEMBL3401162)
Affinity DataKi:  40nMAssay Description:Irreversible inhibition of rat hormone sensitive lipase assessed as relative residual activity by kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147315(2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138750(3-(4-Chloro-phenyl)-5-methylsulfanyl-[1,2,4]triazo...)
Affinity DataIC50:  0.353nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138739(4-tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazo...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138743(5-Methylsulfanyl-3-p-tolyl-[1,2,4]triazole-1-carbo...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147297(4-Isopropyl-2-[4-(3-methoxy-phenyl)-piperazine-1-c...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147299(4-Butyl-3-methyl-2-(4-methyl-piperidine-1-carbonyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147299(4-Butyl-3-methyl-2-(4-methyl-piperidine-1-carbonyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50142719(CHEMBL49895 | Morpholin-4-yl-carbamic acid 4-[(4-t...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138742(3-(4-Chloro-phenyl)-5-propylsulfanyl-[1,2,4]triazo...)
Affinity DataIC50:  1.06nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138758(3-(4-Chloro-phenyl)-5-cyclopropylmethylsulfanyl-[1...)
Affinity DataIC50:  1.09nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138759(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50:  1.76nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138733(5-Methylsulfanyl-3-(4-trifluoromethyl-phenyl)-[1,2...)
Affinity DataIC50:  1.76nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138745((3-(4-chlorophenyl)-5-(methylthio)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.76nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138761(5-Methylsulfanyl-3-p-tolyl-[1,2,4]triazole-1-carbo...)
Affinity DataIC50:  1.76nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50233398(CHEMBL4063082)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using PNPB as substrate after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50233398(CHEMBL4063082)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cells using PNPB as substrate after 5 mins by spectrophotometric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147243(4-Isopropyl-3-methyl-2-(piperidine-1-carbonyl)-2H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147243(4-Isopropyl-3-methyl-2-(piperidine-1-carbonyl)-2H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147251(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147270(3-Methyl-4-(2-phenoxy-ethyl)-2-(piperidine-1-carbo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147251(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM121019(US8722721, 11)
Affinity DataIC50:  2.40nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138749(3-(4-Chloro-phenyl)-5-methylsulfanyl-[1,2,4]triazo...)
Affinity DataIC50:  2.82nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50138735((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147251(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147257(4-(2-Ethoxy-ethyl)-3-methyl-2-(4-methyl-piperidine...)
Affinity DataIC50:  3nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138737(3-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethylsulfan...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147257(4-(2-Ethoxy-ethyl)-3-methyl-2-(4-methyl-piperidine...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50142713((3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147281(4-Isobutyl-3-methyl-2-(4-methyl-piperidine-1-carbo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138735((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147281(4-Isobutyl-3-methyl-2-(4-methyl-piperidine-1-carbo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138747((3-(4-chlorophenyl)-5-(cyclopropylmethylthio)-1H-1...)
Affinity DataIC50:  3.53nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM121018(US8722721, 10)
Affinity DataIC50:  3.70nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138731(3-(4-Chloro-phenyl)-5-ethylsulfanyl-[1,2,4]triazol...)
Affinity DataIC50:  3.71nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147272(4-(2-Methoxy-ethyl)-3-methyl-2-(4-m-tolyl-piperidi...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147241(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147245(4-Isobutyl-3-methyl-2-(4-phenyl-piperidine-1-carbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147267(4-Cyclohexyl-3-methyl-2-(4-methyl-piperidine-1-car...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147279(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147241(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147270(3-Methyl-4-(2-phenoxy-ethyl)-2-(piperidine-1-carbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147270(3-Methyl-4-(2-phenoxy-ethyl)-2-(piperidine-1-carbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147253(2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-isop...)
Affinity DataIC50:  4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147267(4-Cyclohexyl-3-methyl-2-(4-methyl-piperidine-1-car...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147279(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50138751(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50:  4.41nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147289(4-Isobutyl-3-methyl-2-(piperidine-1-carbonyl)-2H-i...)
Affinity DataIC50:  5nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50147298(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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