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Found 19 Enz. Inhib. hit(s) with Target = 'Inositol 1,4,5-trisphosphate receptor type 3'
LigandPNGBDBM50132166(1,2,4,5-InsP4 | CHEMBL100498 | Phosphoric acid mon...)
Affinity DataKi:  26.4nMAssay Description:Compound was evaluated for its ability to displace [3H]Ins(1,4,5)P3 from membranes prepared from bovine adrenal corticlesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075651(1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosph...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075647(CHEMBL283791 | Phosphoric acid mono-((1R,2S,3R,4S,...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50069314(CHEMBL346769 | D-MYO-INOSITOL 1,2,4,5-TETRAKISPHOS...)
Affinity DataIC50:  13nMAssay Description:Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075648((1R,3S,4R,6R)-4,5,6-trihydroxy-2-methyl-2,3-bis(ph...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075649(1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosph...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50069313(CHEMBL158474 | Phosphoric acid mono-((1S,2S,3R,4S,...)
Affinity DataIC50:  598nMAssay Description:Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075650(1D-myo-inositol 3,4,5,6-tetrakisphosphate | 1L-myo...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082885(CHEMBL144954 | Phosphoric acid mono-((1R,2R,3S,4R,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082887(CHEMBL18162 | Phosphoric acid mono-((1R,2S,3S,4R,5...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082886(CHEMBL355920 | Phosphoric acid mono-((1R,2R,3R,4R,...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082888(CHEMBL278700 | Phosphoric acid mono-((1R,3R,4R)-3,...)
Affinity DataIC50:  3.90E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50082889(CHEMBL145009 | Phosphoric acid mono-((1R,2S,3S,4R,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataIC50:  1.40E+4nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50279840((D)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-tripho...)
Affinity DataEC50:  210nMAssay Description:Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Ins(1,4,5)P3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50078574(CHEMBL46273 | inositol 1,4,5-trisphosphate analogu...)
Affinity DataKd:  188nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50078573(CHEMBL297235 | Phosphoric acid 3-amino-propyl este...)
Affinity DataKd:  1.12E+3nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50078572(CHEMBL172534 | CHEMBL297496 | {4-[(4-Dimethylamino...)
Affinity DataKd:  1.20nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol 1,4,5-trisphosphate receptor type 3(Homo sapiens (Human))
Bergische UniversitäT Wuppertal

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKd:  195nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair