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Found 117 Enz. Inhib. hit(s) with Target = 'Large neutral amino acids transporter small subunit 1'
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  79nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  200nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319696((+/-)-2-endo-amino-bis(2-chloroethyl)-7'-aminobenz...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319694((+/-)-2-Amino-(bis-2-chloroethyl)-5-aminoindane-2-...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025838((+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid ...)
Affinity DataKi:  7.70E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319693((+/-)-2-Aminoindane-2-carboxylic acid | CHEMBL1082...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319695((+/-)-2-Aminobenzo-bicyclo-[2.2.1]heptane-2'-exo-c...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM18073((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025837((S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phen...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319691((+/-)-2-amino-6-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Rattus norvegicus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319692((+/-)-2-amino-8-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  2.52E+5nMAssay Description:Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606667(CHEMBL5220432)
Affinity DataKi:  2.10E+6nMAssay Description:Competitive inhibition of human LAT1 expressed in HEK293 cells assessed as inhibition of L-[14C]-Leucine uptake by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50:  60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50:  60nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50:  790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532381(CHEMBL4538666)
Affinity DataIC50:  790nMAssay Description:Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50528545(CHEMBL4526588)
Affinity DataIC50:  980nMAssay Description:Inhibition of recombinant human LAT1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50540285(CHEMBL4642431)
Affinity DataIC50:  3.48E+3nMAssay Description:Induction of LAT1-mediated polyamine efflux in human L3.6PL cells assessed as reduction in cell viability after 48 hrs by MTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50174344(CHEMBL58129)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50174344(CHEMBL58129)
Affinity DataIC50:  6.60E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50174345(CHEMBL3809112)
Affinity DataIC50:  7.30E+3nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50174345(CHEMBL3809112)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50174343(CHEMBL3809645)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340672(US9771316, Example 70)
Affinity DataIC50:  1.04E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463188(CHEMBL4248463)
Affinity DataIC50:  1.70E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532380(CHEMBL4522605)
Affinity DataIC50:  1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50532380(CHEMBL4522605)
Affinity DataIC50:  1.82E+4nMAssay Description:Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606666(CHEMBL5219332)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of LAT1 in human MCF7 cells assessed as inhibition of leucine uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM181118(US9138393, Histidine | US9144538, Histidine)
Affinity DataIC50:  2.00E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463321(CHEMBL4239455)
Affinity DataIC50:  2.77E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463211(CHEMBL4244215)
Affinity DataIC50:  2.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463322(CHEMBL4242544)
Affinity DataIC50:  3.24E+4nMAssay Description:Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463202(CHEMBL4241703)
Affinity DataIC50:  3.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340669(US9771316, Example 68)
Affinity DataIC50:  3.64E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340672(US9771316, Example 70)
Affinity DataIC50:  3.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340542(US9771316, Example 44)
Affinity DataIC50:  3.94E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM36161(D-phenylalanine)
Affinity DataIC50:  4.60E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340549(US9771316, Example 48)
Affinity DataIC50:  5.66E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340539(US9771316, Example 26)
Affinity DataIC50:  5.70E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340532(US9771316, Example 1)
Affinity DataIC50:  5.75E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340661(US9771316, Example 66)
Affinity DataIC50:  6.28E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340536(US9771316, Example 12)
Affinity DataIC50:  6.30E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50:  6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463208(CHEBI:16414 | L-Valine | NSC-76038 | Valine)
Affinity DataIC50:  6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463186(CHEMBL4242404)
Affinity DataIC50:  6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50463186(CHEMBL4242404)
Affinity DataIC50:  6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM18073((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Affinity DataIC50:  6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
Guang Xi University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM340671(US9771316, Example 69)
Affinity DataIC50:  6.90E+4nMAssay Description:Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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