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Found 1617 Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50116538(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Affinity DataKi:  3nMAssay Description:Non-competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50505156(CHEMBL4559677)
Affinity DataKi:  4.60nMAssay Description:Inhibition of human recombinant LTA4H by L-(4-benzoyl)phenylalanyl-beta-naphthylamide fluorigenic substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50505153(CHEMBL4543986)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human recombinant LTA4H by L-(4-benzoyl)phenylalanyl-beta-naphthylamide fluorigenic substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against LTA 4 hydrolase in aminopeptidase assayMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  18nMAssay Description:Inhibitory activity against LTA 4 hydrolase in epoxide hydrolase assayMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046316(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Affinity DataKi:  18nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046314(3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid ...)
Affinity DataKi:  46nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441909(CHEMBL2437292)
Affinity DataKi:  93nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKi:  160nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441915(CHEMBL2437298)
Affinity DataKi:  172nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  320nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197084(CHEMBL3883608)
Affinity DataKi:  360nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441914(CHEMBL2437296)
Affinity DataKi:  369nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441912(CHEMBL2437295)
Affinity DataKi:  607nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441916(CHEMBL2437300)
Affinity DataKi:  629nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441910(CHEMBL2437293)
Affinity DataKi:  643nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441918(CHEMBL2437302)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441911(CHEMBL2437294)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441913(CHEMBL2437297)
Affinity DataKi:  2.59E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441917(CHEMBL2437299)
Affinity DataKi:  3.56E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  3.70E+3nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441908(CHEMBL2437291)
Affinity DataKi:  4.29E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23978((3Z)-3-[(3-phenylpropoxy)imino]-1,2,3,4-tetrahydro...)
Affinity DataKi:  6.00E+3nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23979((3Z)-3-[(4-phenylbutoxy)imino]-1,2,3,4-tetrahydron...)
Affinity DataKi:  8.00E+3nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50441919(CHEMBL2437301)
Affinity DataKi:  8.65E+3nMAssay Description:Inhibition of human leukotriene A-4 hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046327(3-Amino-1,4-diphenyl-butan-2-one | CHEMBL70658)
Affinity DataKi:  1.40E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046331(((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046331(((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Compound was tested for inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23980((3Z)-3-{[(5-phenylpentyl)oxy]imino}-1,2,3,4-tetrah...)
Affinity DataKi:  3.00E+4nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50279808((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Affinity DataKi:  5.00E+4nMAssay Description:Compound was tested for inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50279808((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid me...)
Affinity DataKi:  5.00E+4nMAssay Description:Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397950(CHEMBL2179972)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397951(CHEMBL2179981)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397952(CHEMBL2179979)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397953(CHEMBL2179978)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397954(CHEMBL2179977)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397949(CHEMBL2179973)
Affinity DataKi: >1.00E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397956(CHEMBL2179974)
Affinity DataKi:  3.80E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397957(CHEMBL2179980)
Affinity DataKi:  4.70E+5nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397955(CHEMBL2179976)
Affinity DataKi: >1.00E+6nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50397948(CHEMBL2179975)
Affinity DataKi: >1.00E+6nMAssay Description:Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM326921(4-(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl...)
Affinity DataIC50:  0.0420nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM326945(1-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50:  0.0700nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM327137(4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50:  0.0800nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM326957(N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50:  0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM327016((3S)-3-{4-[(1s,4s)-7- azabicyclo[2.2.1]hept-7- y...)
Affinity DataIC50:  0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM327189(5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin...)
Affinity DataIC50:  0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM327181(1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,...)
Affinity DataIC50:  0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM326947(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...)
Affinity DataIC50:  0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM326992((3S)-3-[4-(azepan-1- ylmethyl)phenyl]-2,3- dihyd...)
Affinity DataIC50:  0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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