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Found 10 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 4'
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531902(CHEMBL4569405)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50:  600nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM124260(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50:  970nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM124263(Bis(4-bromo-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50:  2.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM124264(Bis(4-nitro-2-((phenylimino)methyl)phenolate)-oxov...)
Affinity DataIC50:  3.20E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50:  3.60E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531901(CHEMBL4540813)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM231167(US9340574, 7)
Affinity DataIC50: >1.00E+4nMpH: 7.0Assay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50531903(CHEMBL4530344)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MEG1 catalytic domain (637 to 926 residues) expressed in Escherichia coli using p-nitrophenol a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 4(Homo sapiens (Human))
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50107739(CHEMBL140954 | [(4-{4-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  1.46E+5nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase PTPmeg-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed