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Found 5360 Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase'
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574654(CHEMBL4870906)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574655(CHEMBL4852896)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574656(CHEMBL4866490)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50605682(CHEMBL5176915)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate assessed as inhibition constant by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562160(CHEMBL4757403)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50540526(CHEMBL4637658)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of human recombinant MAGL at 31.25 nM to 125 nM pre-incubated for 5 mins before MAGL substrate addition and further incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562158(CHEMBL4747585)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562161(CHEMBL4755606)
Affinity DataKi:  30nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562159(CHEMBL4798508)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataKi:  39nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten-based plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50600140(CHEMBL5174588)
Affinity DataKi:  60nMAssay Description:Mixed inhibition MAGL (unknown origin) using 4-nitrophenyl acetate as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50394369(CHEMBL2159781)
Affinity DataKi:  75.7nMAssay Description:Irreversible inhibition of human MAGL using p-nitrophenylpropionate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataKi:  412nMAssay Description:Competitive inhibition of recombinant human MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50470454(CHEMBL4282040)
Affinity DataKi:  650nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 mins by Michaelis-Menten kinetics analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50274152((2S,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Affinity DataKi:  2.18E+4nMAssay Description:Inhibition of Sprague-Dawley rat MGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50274153((2R,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of Sprague-Dawley rat MGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50379241(CHEMBL2011479)
Affinity DataKi:  4.00E+4nMAssay Description:Non-competitive inhibition of human recombinant MAGL assessed as 7-hydroxycoumarin level using umbelliferyl arachidonate as substrate by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50274151(CHEMBL473249 | hexadecane-1,2-diamine dihydrochlor...)
Affinity DataKi:  5.87E+4nMAssay Description:Inhibition of Sprague-Dawley rat MGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50479142(Guineensine | Guineesine | Pipyahyine)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of MAGL in human U937 cell homogenates using [3H]-2OG as substrate preincubated for 15 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM640384((S)-(2-Chloro-6-fluorophenyl)(3-(3,5-difluoropheny...)
Affinity DataIC50:  0.00200nMAssay Description:The assay consists of combining endogenously expressed MGL from HeLa cells with test compounds, adding [glycerol-1,3-3H]-oleyl glycerol, incubating f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60)
Affinity DataIC50:  0.00700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60)
Affinity DataIC50:  0.00720nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581474((2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...)
Affinity DataIC50:  0.0140nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM609871((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabic...)
Affinity DataIC50:  0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71)
Affinity DataIC50:  0.0240nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71)
Affinity DataIC50:  0.0240nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581599((2r,4s)-2-(2-(5-(tert-Butyl)-2-methylphenyl)-7-aza...)
Affinity DataIC50:  0.0270nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552710(CHEMBL4749516)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM609880((rac)-(2s,4s)-2-(6-(4-(1-Methylcyclopropyl)phenyl)...)
Affinity DataIC50:  0.0340nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581624((rac)-(2s,4s)-2-(2-(4-(Trifluoromethyl)phenyl)-8-a...)
Affinity DataIC50:  0.0390nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552709(CHEMBL4759880)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552711(CHEMBL4785835)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50:  0.0400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581534((2s,4s)-2-[2-(3-Isopropylphenyl)-7-azaspiro[3.5]no...)
Affinity DataIC50:  0.0410nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581597((2s,4s)-2-[2-(2,4-Dimethylphenyl)-7-azaspiro[3.5]n...)
Affinity DataIC50:  0.0480nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552713(CHEMBL4745872)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of California

Curated by ChEMBL
LigandPNGBDBM50247050(4-cyanophenyl ethyl dodecylphosphonate | CHEMBL462...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM609878((rac)-(2s,4s)-2-(6-(3-Chloro-4-methylphenyl)-3- az...)
Affinity DataIC50:  0.0750nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581596((2r,4s)-2-(2-(3-(tert-Butyl)phenyl)-7-azaspiro[3.5...)
Affinity DataIC50:  0.0820nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581635((rac)-(2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspi...)
Affinity DataIC50:  0.0860nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581518((2s,4s)-2-[2-(3-Cyclopropylphenyl)-7-azaspiro[3.5]...)
Affinity DataIC50:  0.0880nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581594((2s,4s)-2-[2-[3-(Trifluoromethoxy)phenyl]-7-azaspi...)
Affinity DataIC50:  0.0940nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581601((2r,4s)-2-(2-(6-(tert-Butyl)pyridin-2-yl)-7-azaspi...)
Affinity DataIC50:  0.0950nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581650((2s,4s)-2-(6-(3-(tert-Butyl)phenyl)-2-azaspiro[3.3...)
Affinity DataIC50:  0.0970nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552708(CHEMBL4756662)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50552712(CHEMBL4749293)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM630876((7-((3,6-Dimethyl-5-(trifluoromethyl)pyridin-2-yl)...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581642((rac)-(2s,4s)-2-(2-(3-(tert-Butyl)phenyl)-8-azaspi...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM581648((rac)-(2s,4s)-2-(6-(4-Isopropylphenyl)-2-azaspiro[...)
Affinity DataIC50:  0.100nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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