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Found 126 Enz. Inhib. hit(s) with Target = '2-5A-dependent ribonuclease'
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085553(CHEMBL214603 | Oligoadenylate analogue)
Affinity DataIC50:  0.720nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  0.950nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370220(CHEMBL1163094)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370219(CHEMBL610868)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025002(CHEMBL404038 | ppp'A2'p5'A2'p5'A | ppp5'A2'p5'A2'p...)
Affinity DataIC50:  2.30nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085558(CHEMBL402676 | Oligoadenylate analogue)
Affinity DataIC50:  2.60nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085554(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Affinity DataIC50:  7.30nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  13nMAssay Description:Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluatedMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytesMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085556(CHEMBL405496 | Oligoadenylate analogue)
Affinity DataIC50:  24nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025005(CHEMBL3143469 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A))
Affinity DataIC50:  48nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370222(CHEMBL610866)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50366437(CHEMBL608874)
Affinity DataIC50:  50nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extractChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085555(CHEMBL384725 | Oligoadenylate analogue)
Affinity DataIC50:  57nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370227(CHEMBL610609)
Affinity DataIC50:  70nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085559(CHEMBL410213 | Oligoadenylate analogue)
Affinity DataIC50:  105nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025001(CHEMBL3143411 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A)2'...)
Affinity DataIC50:  150nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50021104((2'-5'(pAris)3)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025000(CHEMBL3143409 | ppp5'(br8A)2'p5'(br8A)2'p5'(br8A))
Affinity DataIC50:  250nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50021104((2'-5'(pAris)3)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370221(CHEMBL610855)
Affinity DataIC50:  500nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50024997(CHEMBL3143462 | p5'(br8A)2'p5'(br8A)2'p5'(br8A))
Affinity DataIC50:  700nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370224(CHEMBL610867)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025003((br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL3143413)
Affinity DataIC50:  1.00E+3nMAssay Description:compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50366437(CHEMBL608874)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50085557(CHEMBL407239 | Oligoadenylate analogue)
Affinity DataIC50:  1.06E+3nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 5 nM 2-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 1 nM 2-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 20 nM 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50021104((2'-5'(pAris)3)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370229(CHEMBL607600)
Affinity DataIC50:  5.00E+3nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025006((br8A)2'p5'(br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL31...)
Affinity DataIC50: >4.00E+4nMAssay Description:compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50366438(CHEMBL608875)
Affinity DataIC50:  4.00E+4nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extractChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50366436(CHEMBL605454)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extractChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025004(CHEMBL3143467 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...)
Affinity DataIC50: >5.00E+4nMAssay Description:compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50366436(CHEMBL605454)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50366438(CHEMBL608875)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370223(CHEMBL607888)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370225(CHEMBL608161)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370226(CHEMBL607595)
Affinity DataIC50:  1.00E+5nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370228(CHEMBL607882)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50370230(CHEMBL610610)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50362886(VITEXIN)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50024998(CHEMBL3143412 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...)
Affinity DataIC50: >2.00E+5nMAssay Description:compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50024999(CHEMBL414948 | Sulfuric acid mono-{5-(6-amino-puri...)
Affinity DataIC50:  2.00E+5nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  2.64E+5nMAssay Description:Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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